In:
Zeitschrift für Naturforschung C, Walter de Gruyter GmbH, Vol. 60, No. 1-2 ( 2005-2-1), p. 63-66
Abstract:
Bioactivity-guided fractionation of the methanol extract from the leaves of Santolina insularis led to the isolation of one new xanthone, (E)-3-{6-[(E)-3-hydroxy-3-oxo-1-propenyl]-9- oxo-9H-xanthen-2-yl}-2-propenoic acid, together with six known flavonoids: hispidulin, nepetin, cirsimaritin, rhamnocitrin, luteolin and luteolin 7-O-β-ᴅ-glucopyranoside. The structures were elucidated by means of 1D-, 2D-NMR spectroscopy and mass spectrometry. The topical anti-inflammatory activity of all isolated compounds and extracts was investigated employing the croton oil-induced dermatitis in mouse ear. The most active compound, luteolin, showed an ID 50 of 0.3 μmol/cm 2 and prevented ear oedema more effectively than an equimolar dose of indomethacin within 24 h.
Type of Medium:
Online Resource
ISSN:
1865-7125
,
0939-5075
DOI:
10.1515/znc-2005-1-212
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2005
detail.hit.zdb_id:
2078107-6
SSG:
12
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