In:
Respiration, S. Karger AG, Vol. 74, No. 2 ( 2007), p. 176-183
Abstract:
〈 i 〉 Background: 〈 /i 〉 Left ventricular (LV) hypertrophy is a common consequence of systemic hypertension (SH) and obstructive sleep apnea (OSA). However, little is known about the degree of LV involvement in patients with OSA coexisting with treated SH. 〈 i 〉 Objectives: 〈 /i 〉 Our study was designed in order to assess the prevalence of distinct types of LV geometry in treated hypertensive OSA patients. 〈 i 〉 Methods: 〈 /i 〉 Patients: 183 patients with treated SH were enrolled to the study. Group 1 consisted of 38 patients with newly-diagnosed OSA and ineffectively treated SH. The remaining 145 patients with effectively treated SH were divided into three groups: group 2 – 70 patients with newly-diagnosed OSA, group 3 – 31 patients with OSA treated with continuous positive airway pressure (CPAP), and group 4 – 44 patients without OSA.Overnight sleep studies and M-mode echocardiography were performed. 〈 i 〉 Results: 〈 /i 〉 LV mass index did not differ between the study groups. Mean values of LV end-diastolic diameter (LVED) were 55.4 ± 6.8 mm in group 1 and 53.6 ± 6.9 mm in group 2 and were significantly increased in comparison to subjects treated with CPAP and controls (49.8 ± 6.8 mm and 50.1 ± 64.7 mm, respectively; p = 0.001). LVED correlated positively with the apnea-hypopnea index and desaturation index. LV eccentric hypertrophy was the commonest type of LV geometry in newly-diagnosed OSA patients. 〈 i 〉 Conclusions: 〈 /i 〉 The major finding of our study is the predominance of LV eccentric hypertrophy in newly-diagnosed OSA patients. We suggest that a relatively moderate degree of LV involvement in hypertensive OSA patients may depend on the cardioprotective effect of concomitant antihypertensive therapy, ameliorating OSA-dependent neurohumoral abnormalities.
Type of Medium:
Online Resource
ISSN:
0025-7931
,
1423-0356
Language:
English
Publisher:
S. Karger AG
Publication Date:
2007
detail.hit.zdb_id:
1464419-8
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