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  • 1
    Online Resource
    Online Resource
    Depression assessment and classification in palliative cancer patients: a systematic literature review
    SAGE Publications ; 2009
    In:  Palliative Medicine Vol. 23, No. 8 ( 2009-12), p. 739-753
    Details
    In: Palliative Medicine, SAGE Publications, Vol. 23, No. 8 ( 2009-12), p. 739-753
    Abstract: The objective of this study was to review the literature on depression in palliative cancer care in order to identify which assessment methods and classification systems have been used in studies of depression. Extensive electronic database searches in PubMed, CancerLit, CINAHL, PsychINFO, EMBASE and AgeLine as well as hand search were carried out. In the 202 included papers, 106 different assessment methods were used. Sixty-five of these were only used once. All together, the Hospital Anxiety and Depression Scale (HADS) was the most commonly used assessment method. However, there were regional differences and while the HADS dominated in Europe it was quite seldom used in Canada or in the USA. Few prevalence and intervention studies used assessment methods with an explicit reference to a diagnostic system. There were in total few case definitions of depression. Among these, the classifications were in general based on cut-off scores (77%) and not according to diagnostic systems. The full range of the DSM-IV diagnostic criteria was seldom assessed, i.e. less than one-third of the assessments in the review took into account the duration of symptoms and 18% assessed consequences and impact upon patient functioning. A diversity of assessment methods had been used. Few studies classified depression by referring to a diagnostic system or by using cut-off scores. Evidently, there is a need for a consensus on how to assess and conceptualize depression and related conditions in palliative care.
    Type of Medium: Online Resource
    ISSN: 0269-2163 , 1477-030X
    URL: Article
    DOI: 10.1177/0269216309106978
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2027566-3
    detail.hit.zdb_id: 639247-7
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  • 2
    Online Resource
    Online Resource
    Antiretroviral treatment for injecting drug users in developing and transitional countries 1 year before the end of the ‘Treating 3 million by 2005. Making it happen. The WHO strategy’ (‘3by5’)*
    Wiley ; 2006
    In:  Addiction Vol. 101, No. 9 ( 2006-09), p. 1246-1253
    Details
    In: Addiction, Wiley, Vol. 101, No. 9 ( 2006-09), p. 1246-1253
    Abstract: Objective  To describe and estimate the availability of antiretroviral treatment (ART) to injecting drug users (IDUs) in developing and transitional countries. Methods  Literature review of grey and published literature and key informants’ communications on the estimated number of current/former injecting drug users (IDUs) receiving ART and the proportion of human immunodeficiency virus (HIV) attributed to injecting drug use (IDU), the number of people in ART and in need of ART, the number of people living with HIV/acquired immunodeficiency syndrome (AIDS) (PLWHA) and the main source of ART. Results  Data on former/current IDUs on ART were available from 50 countries (in 19 countries: nil IDUs in treatment) suggesting that ∼34 000 IDUs were receiving ART by the end of 2004, of whom 30 000 were in Brazil. In these 50 countries IDUs represent ∼15% of the people in ART. In Eastern European and Central Asia IDU are associated with 〉  80% of HIV cases but only ∼2000 (14%) of the people in ART. In South and South‐East Asia there were ∼1700 former/current IDUs receiving ART (∼1.8% of the people in ART), whereas the proportion of HIV cases associated to IDU is 〉  20% in five countries (and regionally ranges from 4% to 75%). Discussion  There is evidence that the coverage of ART among current/former IDUs is proportionally substantially less than other exposure categories. Ongoing monitoring of ART by exposure and population subgroups is critical to ensuring that scale‐up is equitable, and that the distribution of ART is, at the very least, transparent.
    Type of Medium: Online Resource
    ISSN: 0965-2140 , 1360-0443
    URL: Issue
    URL: Article
    DOI: 10.1111/add.2006.101.issue-9
    DOI: 10.1111/j.1360-0443.2006.01509.x
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 1141051-6
    detail.hit.zdb_id: 2002997-4
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  • 3
    Online Resource
    Online Resource
    A sequence‐anchored genetic linkage map for the moss, Physcomitrella patens
    Wiley ; 2008
    In:  The Plant Journal Vol. 56, No. 5 ( 2008-12), p. 855-866
    Details
    In: The Plant Journal, Wiley, Vol. 56, No. 5 ( 2008-12), p. 855-866
    Abstract: The moss Physcomitrella patens is a model for the study of plant cell biology and, by virtue of its basal position in land plant phylogeny, for comparative analysis of the evolution of plant gene function and development. It is ideally suited for ‘reverse genetic’ analysis by virtue of its outstanding ability to undertake targeted transgene integration by homologous recombination. However, gene identification through mutagenesis and map‐based cloning has hitherto not been possible, due to the lack of a genetic linkage map. Using molecular markers [amplified fragment length polymorphisms (AFLP) and simple sequence repeats (SSR)] we have generated genetic linkage maps for Physcomitrella. One hundred and seventy‐nine gene‐specific SSR markers were mapped in 46 linkage groups, and 1574 polymorphic AFLP markers were identified. Integrating the SSR‐ and AFLP‐based maps generated 31 linkage groups comprising 1420 markers. Anchorage of the integrated linkage map with gene‐specific SSR markers coupled with computational prediction of AFLP loci has enabled its correspondence with the newly sequenced Physcomitrella genome. The generation of a linkage map densely populated with molecular markers and anchored to the genome sequence now provides a resource for forward genetic interrogation of the organism and for the development of a pipeline for the map‐based cloning of Physcomitrella genes. This will radically enhance the potential of Physcomitrella for determining how gene function has evolved for the acquisition of complex developmental strategies within the plant kingdom.
    Type of Medium: Online Resource
    ISSN: 0960-7412 , 1365-313X
    URL: Issue
    URL: Article
    DOI: 10.1111/tpj.2008.56.issue-5
    DOI: 10.1111/j.1365-313X.2008.03637.x
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2020961-7
    detail.hit.zdb_id: 1088037-9
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Deleterious SNP prediction: be mindful of your training data!
    Oxford University Press (OUP) ; 2007
    In:  Bioinformatics Vol. 23, No. 6 ( 2007-03-15), p. 664-672
    Details
    In: Bioinformatics, Oxford University Press (OUP), Vol. 23, No. 6 ( 2007-03-15), p. 664-672
    Abstract: Motivation: To predict which of the vast number of human single nucleotide polymorphisms (SNPs) are deleterious to gene function or likely to be disease associated is an important problem, and many methods have been reported in the literature. All methods require data sets of mutations classified as ‘deleterious’ or ‘neutral’ for training and/or validation. While different workers have used different data sets there has been no study of which is best. Here, the three most commonly used data sets are analysed. We examine their contents and relate this to classifiers, with the aims of revealing the strengths and pitfalls of each data set, and recommending a best approach for future studies. Results: The data sets examined are shown to be substantially different in content, particularly with regard to amino acid substitutions, reflecting the different ways in which they are derived. This leads to differences in classifiers and reveals some serious pitfalls of some data sets, making them less than ideal for non-synonymous SNP prediction. Availability: Software is available on request from the authors. Contact:  d.r.westhead@leeds.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online.
    Type of Medium: Online Resource
    ISSN: 1367-4811 , 1367-4803
    URL: Article
    DOI: 10.1093/bioinformatics/btl649
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2007
    detail.hit.zdb_id: 1468345-3
    detail.hit.zdb_id: 1422668-6
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    An Expanded Set of Direct BLIMP-1 Targets Identifies Novel Links in Differentiation, Immune Response and Lymphoma.
    American Society of Hematology ; 2009
    In:  Blood Vol. 114, No. 22 ( 2009-11-20), p. 1466-1466
    Details
    In: Blood, American Society of Hematology, Vol. 114, No. 22 ( 2009-11-20), p. 1466-1466
    Abstract: Abstract 1466 Poster Board I-489 B-lymphocyte induced maturation protein 1 (BLIMP-1) has been defined as a key driver of the genetic reprogramming during differentiation of B-cells to plasma cells. Frequent inactivation of PRDM1, the BLIMP-1 gene, in diffuse large B-cell lymphoma (DLBCL) indicates that loss of function is an important event in lymphomagenesis. Only a limited set of direct BLIMP-1 target genes have been defined. In order to better understand the function of human BLIMP-1 in differentiation and malignancy we have established a more comprehensive set of occupied promoters. These data provide an extended view of the regulatory network controlled by BLIMP-1, and identify novel sets of targets involved in transcription and immune response. The composition of occupied promoters identifies complexity in BLIMP-1 binding motif selection, and substantial overlap between BLIMP-1 sites and Interferon regulatory factor (IRF) elements. Consistent with active competition between BLIMP-1 and IRFs, target genes associated with such overlapping motifs are found to be preferentially induced in response to BLIMP-1 knockdown. Finally BLIMP-1 targets are found to include key components of DLBCL gene expression signatures. This map of BLIMP-1 occupied promoters thus illuminates key aspects of function in normal and malignant cell biology. Disclosures: No relevant conflicts of interest to declare.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V114.22.1466.1466
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2009
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 6
    Online Resource
    Online Resource
    Predicting the effect of missense mutations on protein function: analysis with Bayesian networks
    Springer Science and Business Media LLC ; 2006
    In:  BMC Bioinformatics Vol. 7, No. 1 ( 2006-12)
    Details
    In: BMC Bioinformatics, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2006-12)
    Type of Medium: Online Resource
    ISSN: 1471-2105
    URL: Article
    DOI: 10.1186/1471-2105-7-405
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2006
    detail.hit.zdb_id: 2041484-5
    SSG: 12
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