In:
Key Engineering Materials, Trans Tech Publications, Ltd., Vol. 342-343 ( 2007-7), p. 841-844
Kurzfassung:
Lactate dehydrogenase (LDH) and enzyme-linked immunosorbent assay (ELISA) have
attracted much attention recently for the evaluation of blood compatibility of biomaterials due to their convenience and quantifiability. In this paper, the use of LDH and ELISA is described for in
situ investigation of platelet behavior on biomaterial surfaces, including quantification of platelet adhesion and platelet activation, after suitable testing conditions have been established. The
material samples investigated in these tests included low temperature isotropic carbon (LTIC), Ti-O films, and phosphorus- and aluminum-doped TiO2 films. The evaluation results show that the
lowest platelet adhesion and activation are observed on phosphorus-doped TiO2 films while the highest platelet adhesion and activation are observed on LTIC. In addition, conventional platelet
adhesion experiments were performed for comparison, and yielding similar evaluation results as LDH and ELISA. It is suggested that LDH and ELISA tests can be successfully applied to evaluate
the blood compatibility of biomaterials and can show many advantages, such as quantification, reliability and objectivity, compared with conventional platelet adhesion test.
Materialart:
Online-Ressource
ISSN:
1662-9795
DOI:
10.4028/www.scientific.net/KEM.342-343
DOI:
10.4028/www.scientific.net/KEM.342-343.841
Sprache:
Unbekannt
Verlag:
Trans Tech Publications, Ltd.
Publikationsdatum:
2007
ZDB Id:
2073306-9
Permalink