In:
British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 193, No. 4 ( 2008-10), p. 316-321
Abstract:
Previous studies have reported the association between advanced paternal
age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability. Aims To test whether an association between advanced paternal age at birth is
found in offspring with high-functioning autistic-spectrum disorder (i.e. offspring without intellectual disability). Method A case–control study was conducted in Japan. The participants consisted
of individuals with full-scale IQ ⩾ 70, with a DSM–IV autistic disorder or related diagnosis. Unrelated healthy volunteers were recruited as
controls. Parental ages were divided into tertiles (i.e. three age classes). Odds ratios and 95% confidence intervals were estimated using
logistic regression analyses, with an adjustment for age, gender and birth order. Results Eighty-four individuals with autistic-spectrum disorder but without
intellectual disability and 208 healthy controls were enrolled. Increased paternal, but not maternal, age was associated with an elevated risk of high-functioning autistic-spectrum disorder. A one-level advance in
paternal age class corresponded to a 1.8-fold increase in risk, after adjustment for covariates. Conclusions Advanced paternal age is associated with an increased risk for
high-functioning autistic-spectrum disorder.
Type of Medium:
Online Resource
ISSN:
0007-1250
,
1472-1465
DOI:
10.1192/bjp.bp.107.045120
Language:
English
Publisher:
Royal College of Psychiatrists
Publication Date:
2008
detail.hit.zdb_id:
2021500-9
Permalink