In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1042, No. 1 ( 2005-05), p. 516-522
Kurzfassung:
A bstract : Cisplatin is an anticancer drug that can induce apoptosis. In this study, we investigated the effect of mitochondrial DNA (mtDNA) depletion on cisplatin‐induced cell death using a human osteosarcoma cell line (143B) and mtDNA‐depleted 143B cells (143B‐ρ 0 ). Results showed that cisplatin decreased cell survival in 143B‐ρ 0 cells. Moreover, cisplatin induced a greater extent of apoptosis‐associated DNA fragmentation and caspase 3 activation in 143B‐ρ 0 cells. The release of mitochondrial cytochrome c into cytosol by cisplatin was enhanced more obviously in 143B cells than in 143B‐ρ 0 cells; however, in the control group of 143B‐ρ 0 cells, it was already dramatically greater. Depletion of mtDNA may increase sensitivity of cells to cisplatin‐induced apoptosis by enhancing caspase 3 activation via both cytochrome c ‐dependent and ‐independent pathways.
Materialart:
Online-Ressource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1196/annals.1338.047
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2005
ZDB Id:
2834079-6
ZDB Id:
211003-9
ZDB Id:
2071584-5
SSG:
11
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