Keywords:
Electronic books.
Description / Table of Contents:
For the first time, this book presents a comprehensive analysis, based on electrons controlling the ion channel gates. The theory and gating model are extensively linked to published experimental observations. The intrinsic simplicity of electron gating elucidates mechanisms important to the functions of nerve cells.
Type of Medium:
Online Resource
Pages:
1 online resource (206 pages)
Edition:
1st ed.
ISBN:
9781613531822
Series Statement:
Materials, Circuits and Devices Series ; v.02
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=1184527
DDC:
571.6/4
Language:
English
Note:
Intro -- Contents -- Preface -- Part I: Theory / Electron-Gated Ion Channels -- 1. Introduction -- 1-1. The electron-gating model -- 1-2. Electron gating of a sodium channel -- 1-3. Timing -- 1-4. Sodium channel current -- 1-5. Sensitivity -- 1-6. Amplification and negative conductance -- 1-7. Model parameters -- 2. Developing A Model -- 2-1. A single electron two-site model -- 2-2. Amplification -- 2-3. A small force constant -- 2-4. Calculating frequencies -- 2-5. Amplification by NH3 inversion resonance -- 2-6. A voltage dependent amplification factor -- 2-7. The amplification energy window -- 2-8. NH3 inversion frequency reduction -- 3. The SetCap Model -- 3-1. A circuit model for two-site electron tunneling -- 3-2. Defining a capacitance factor -- 3-3. Displacement capacitance -- 3-4. Time-constant capacitance -- 3-5. Displacement energy -- 3-6. Energy well depth -- 3-7. The SETCAP model for N tunneling sites -- 4. Amplified Electron Tunneling and the Inverted Region -- 4-1. Amplification and the Marcus inverted region -- 4-2. The Q10 temperature factor -- 4-3. Time constant -- 4-4. Contact resistance -- 4-5. Tunneling resistance -- 4-6. Electron tunneling site-selectivity -- 4-7. The amplification energy window and the inverted region -- 5. Gating and Distortion Factors -- 5-1. Sodium channel inactivation gate leakage -- 5-2. Ion channel gating -- 5-3. Inactivation gating and open-gate distortion -- 5-4. Sodium channel activation gates and distortion -- 5-5. Potassium channel gating and distortion -- 5-6. Edge distortion of inactivation gating -- 5-7. Multistate gating -- 6. Characterization and Validation -- 6-1. Electron gating model equations -- 6-2. Finite-range rate constants -- 6-3. Open-channel probability range and time constant -- 6-4. Rate curves using voltage-sensitive amplification -- 7. Flux Gating In Na+ and K+ Channels.
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7-1. Sodium channel flux gating -- 7-2. Sodium channel inactivation flux gating -- 7-3. Potassium channel flux gating -- 7-4. The influx gating latch-up effect -- 8. Far Sites, Near Sites, and Back Sites -- 8-1. Ion channel mapping -- 8-2. Far sites for inactivation, calcium signaling and memory -- 8-3. Near sites on the S4 -- 8-4. Back sites and hyperpolarization -- 8-5. Gating current -- 8-6. Charge immobilization -- 8-7. A calcium channel oscillator model using far sites -- 9. Electron-Gate K+ Channels -- 9-1. Activation and inactivation of Kv channels -- 9-2. Structural constraints for activation gating -- 9-3. Influx gating latch-up and TEA+sensitivity -- 9-4. K/Na selectivity ratio -- 9-5. C-type inactivation gating -- 9-6. Coupling between tunnel-track electrons -- 9-7. Kinetics and inactivation depend on far sites -- Part II: Experimental Microwave Investigation -- 10. Microwave Thermal Fluorescence Spectroscopy -- 10-1. Microwave spectroscopy for caged proteins -- 10-2. Microwave spectra for Blue Fluorescent Protein -- 10-3. Matching frequencies -- 10-4. Estimating parameters and sensitivity -- 10-5. Arginine and lysine hot spots -- 10-6. Calcium oscillators - microwave sensitivity -- 10-7. The first excited vibrational state -- 10-8. Mode switching at infrared frequencies -- Appendix -- A. Geometric calculations for an or-helix -- B. Time constant for a tunneling distance r -- Final Comments -- A brief review of the findings -- References -- Index.
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