In:
ChemBioChem, Wiley, Vol. 6, No. 11 ( 2005-11-04), p. 2048-2054
Abstract:
The aim of this study was to synthesise pure enantiomers of potent antimalarial 1,2,4‐trioxanes, which are related to the natural antimalarial artemisinin, and then to assay each against a panel of Plasmodium falciparum strains. The working hypothesis was that if the artemisinin derivatives interact with a specific protein‐target site, then there should be stereoselective differences in their activity. In five different P. falciparum isolates, however, the trioxane enantiomers (+)‐ 7 a , (−)‐ 7 a and (+)‐ 7 b , (−)‐ 7 b , showed the same level of in vitro antiparasitic activity.
Type of Medium:
Online Resource
ISSN:
1439-4227
,
1439-7633
DOI:
10.1002/cbic.200500048
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
2020469-3
SSG:
12
Permalink