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  • SAGE Publications  (7)
  • 2005-2009  (7)
  • 1
    Online Resource
    Online Resource
    Potential Prognostic Significance of p185 HER2 Overexpression with Loss of PTEN Expression in Gastric Carcinomas
    SAGE Publications ; 2005
    In:  Tumori Journal Vol. 91, No. 6 ( 2005-11), p. 513-521
    Details
    In: Tumori Journal, SAGE Publications, Vol. 91, No. 6 ( 2005-11), p. 513-521
    Abstract: The HER2 gene encodes a 185-kd transmembrane glycoprotein receptor (p185 HER2 ) that has partial homology with the epidermal growth factor receptor and shares intrinsic tyrosine kinase activity. The phosphatase and tensin homolog mutated on chromosome ten (PTEN) gene product is a protein tyrosine phosphatase that participates in modulating the phosphoinositide 3-kinase pathway which has antagonizing activity to protein tyrosine kinase. The authors investigated the correlation between clinicopathologic variables including survival and the overexpression of the p185 HER2 with loss of PTEN expression in gastric adenocarcinoma patients. Methods The protein expression of p185 HER2 and PTEN was examined by immunohistochemical stain in paraffin-embedded tissues of 94 (M:F, 52:42) gastric adenocarcinoma patients by using monoclonal antibody, and the results were related to clinicopathological variables and survival. Results p185 HER2 overexpression correlated positively with lymph node metastasis, distant metastasis, AJCC classification, higher relapse rate. Patients with overexpression of p185 HER2 were found to have significantly lower disease-free survival ( P = 0.003) and overall survival ( P = 0.0004). Loss of PTEN expression correlated positively with depth of invasion (T stage) and was more frequent in the advanced stage. The patient group with p185 HER2 overexpression and loss of PTEN expression showed significantly shorter disease-free and overall survival ( P = 0.03, P = 0.01) than the other groups. Conclusions Our observations suggest potential prognostic significance of p185 HER2 overexpression with PTEN loss in gastric adenocarcinoma patients. This opens up the possibility of considering p185 HER2 and PTEN as a therapeutic target in gastric cancer.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/030089160509100612
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 2
    Online Resource
    Online Resource
    Testing the Determinants of Computerized Reservation System Users’ Intention to Use Via a Structural Equation Model
    SAGE Publications ; 2006
    In:  Journal of Hospitality & Tourism Research Vol. 30, No. 2 ( 2006-05), p. 246-266
    Details
    In: Journal of Hospitality & Tourism Research, SAGE Publications, Vol. 30, No. 2 ( 2006-05), p. 246-266
    Abstract: This study examines the relationship between users’ personal perceptions and beliefs of the proposed system and their normal day-to-day usage in the context of the travel industry’s computerized reservation systems (CRSs). Using a technology acceptance model as a theoretical background, the influences of three dimensions of fit (i.e., task fit, career fit, and organization fit) on CRS users’ daily routine usage are further explored. Results suggested that proposed users’ usage intentions are motivated by their various evaluations of the given system. Diverse system features and functions should thus be experienced and emphasized in advance according to each organization’s unique business situation. Such experience with the proposed CRS enables users to develop more favorable perceptions and beliefs of the given system, leading consequently to a higher level of day-to-day usage.
    Type of Medium: Online Resource
    ISSN: 1096-3480 , 1557-7554
    URL: Article
    DOI: 10.1177/1096348005285087
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2202405-0
    SSG: 3,2
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  • 3
    Online Resource
    Online Resource
    Three-Fraction Stereotactic Body Radiation Therapy for Isolated Liver Recurrence from Colorectal Cancer
    SAGE Publications ; 2009
    In:  Tumori Journal Vol. 95, No. 4 ( 2009-07), p. 449-454
    Details
    In: Tumori Journal, SAGE Publications, Vol. 95, No. 4 ( 2009-07), p. 449-454
    Abstract: To determine the feasibility and efficacy of 3-fraction stereotactic body radiation therapy for isolated colorectal cancer liver metastases. Materials and methods Ten patients with isolated inoperable liver metastasis from colorectal cancer with progression after salvage chemotherapy underwent stereotactic body radiation therapy. Follow-up was 7–49 months (median, 12). Six patients had a solitary lesion and 4 patients had 2 lesions. Internal target volumes of metastatic liver tumors ranged from 3.4 to 271 ml. Stereotactic body radiation therapy doses ranged from 36 to 51 Gy and were administered in three fractions. All patients demonstrated disease progression despite chemotherapy prior to stereotactic body radiation therapy. Results Three-year overall survival and local control rates were 40% and 60%, respectively. Tumors with an internal target volume 〈 100 ml showed better local control rate than larger tumors. No severe complication was attributed to the therapy. Conclusion Our study suggests the potential feasibility of stereotactic body radiation therapy for selected patients with colorectal cancer liver metastasis and no treatment option. The study showed that excellent local control was achieved in patients with a total tumor volume of 〈 100 ml but failed to clarify the role of stereotactic body radiation therapy for larger tumors. Further large scale studies are needed to define the indications of such therapy.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/030089160909500407
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 4
    Online Resource
    Online Resource
    Marked Prevention of Ischemic Brain Injury by Neu2000, an NMDA Antagonist and Antioxidant Derived from Aspirin and Sulfasalazine
    SAGE Publications ; 2007
    In:  Journal of Cerebral Blood Flow & Metabolism Vol. 27, No. 6 ( 2007-06), p. 1142-1151
    Details
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 27, No. 6 ( 2007-06), p. 1142-1151
    Abstract: Excitotoxicity and oxidative stress mediate neuronal death after hypoxic—ischemic brain injury. We examined the possibility that targeting both N-methyl-d-aspartate (NMDA) receptor-mediated excitotoxicity and oxidative stress would result in enhanced neuroprotection against hypoxic—ischemia. 2-Hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid (Neu2000) was derived from aspirin and sulfasalazine to prevent both NMDA neurotoxicity and oxidative stress. In cortical cell cultures, Neu2000 was shown to be an uncompetitive NMDA receptor antagonist and completely blocked free radical toxicity at doses as low as 0.3 μmol/L. Neu2000 showed marked neuroprotection in a masked fashion using histology and behavioral testing in two rodent models of focal cerebral ischemia without causing neurotoxic side effects. Neu2000 protected against the effects of middle cerebral artery occlusion, even when delivered 8 h after reperfusion. Single bolus administration of the drug prevented gray and white matter degeneration and spared neurologic function for over 28 days after MACO. Neu2000 may be a novel therapy for combating both NMDA receptor-mediated excitotoxicity and oxidative stress, the two major routes of neuronal death in ischemia, offering profound neuroprotection and an extended therapeutic window.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    URL: Article
    DOI: 10.1038/sj.jcbfm.9600418
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2039456-1
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  • 5
    Online Resource
    Online Resource
    The Significance of c-erbB-2 Overexpression and p53 Expression in Patients With Axillary Lymph Node—Negative Breast Cancer: A Tissue Microarray Study
    SAGE Publications ; 2007
    In:  International Journal of Surgical Pathology Vol. 15, No. 2 ( 2007-04), p. 98-109
    Details
    In: International Journal of Surgical Pathology, SAGE Publications, Vol. 15, No. 2 ( 2007-04), p. 98-109
    Abstract: We conducted this study to examine whether the expression of c-erbB-2 and p53 is the prognostic indicator for patients with early-stage breast cancer in which axillary lymph node metastasis is absent. We examined 326 patients with early-stage breast cancer in which axillary lymph node metastasis is absent. Tissue microarrays were constructed. Following this, immunohistochemical staining was done for estrogen receptor (ER), progesterone receptor (PR), c-erbB2, and p53. The results were as follows: (1) expression of c-erbB-2 was correlated with other clinicopathologic factors (eg, patient's age, presence of menopause, tumor size, histologic and nuclear grade, and presence of hormone receptors such as ER and PR); and (2) expression of p53 was correlated with survival rate, patient's age, presence of menopause, and tumor size. However, these results were not statistically significant. In conclusion, our results indicate that expression of c-erbB-2 and p53 did not have any prognostic value in patients with early-stage breast cancer in which axillary lymph node metastasis is absent.
    Type of Medium: Online Resource
    ISSN: 1066-8969 , 1940-2465
    URL: Article
    DOI: 10.1177/1066896906299124
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2070102-0
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  • 6
    Online Resource
    Online Resource
    Brief Screening for Mild Cognitive Impairment in Elderly Outpatient Clinic: Validation of the Korean Version of the Montreal Cognitive Assessment
    SAGE Publications ; 2008
    In:  Journal of Geriatric Psychiatry and Neurology Vol. 21, No. 2 ( 2008-06), p. 104-110
    Details
    In: Journal of Geriatric Psychiatry and Neurology, SAGE Publications, Vol. 21, No. 2 ( 2008-06), p. 104-110
    Abstract: The Montreal Cognitive Assessment (MoCA) is a brief cognitive screening tool with high sensitivity for screening patients with mild cognitive impairment (MCI). The authors examined the validity and reliability of the Korean version of the MoCA (MoCA-K) in elderly outpatients. The MoCA-K, a Korean version of the Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR) scale, and neuropsychological batteries were administered to 196 elderly persons (mild Alzheimer's disease [AD] = 44, MCI = 37, normal controls [NC] = 115). MoCA-K scores were highly correlated with those of MMSE and CDR. Using a cutoff score of 22/23, the MoCA-K had an excellent sensitivity of 89% and a good specificity of 84% for screening MCI. Internal consistency and test−retest reliability were good. The results obtained show that the MoCA-K is brief, reliable, and suitable for use as a screening tool to screen MCI patients in elderly outpatient clinic settings.
    Type of Medium: Online Resource
    ISSN: 0891-9887 , 1552-5708
    URL: Article
    DOI: 10.1177/0891988708316855
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2094096-8
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  • 7
    Online Resource
    Online Resource
    Sequential Bilateral Hearing Loss in Multiple Sclerosis
    SAGE Publications ; 2008
    In:  Annals of Otology, Rhinology & Laryngology Vol. 117, No. 3 ( 2008-03), p. 186-191
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 117, No. 3 ( 2008-03), p. 186-191
    Abstract: Objectives: We describe a case of multiple sclerosis presenting with sequential bilateral hearing loss. Methods: A 46-year-old woman underwent a series of audiological and neurologic evaluations for sequential bilateral hearing losses that occurred 6 months apart. Results: Initially, the patient suffered from sudden left hearing loss, and magnetic resonance imaging documented an enhancing lesion in the left middle cerebellar peduncle. Six months later, another episode of sudden vertigo, right hearing loss, and right facial palsy developed. Magnetic resonance imaging disclosed a new lesion in the right middle cerebellar peduncle. Conclusions: Sequential bilateral hearing loss may be a manifestation of multiple sclerosis. In younger patients with sudden hearing loss, multiple sclerosis should be included in the differential diagnosis.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/000348940811700305
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2033055-8
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