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  • SAGE Publications  (16)
  • 2005-2009  (16)
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  • SAGE Publications  (16)
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  • 2005-2009  (16)
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  • 1
    Online Resource
    Online Resource
    Determination of Storage Lengths of Left-Turn Lanes at Signalized Intersections
    SAGE Publications ; 2007
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2023, No. 1 ( 2007-01), p. 102-111
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2023, No. 1 ( 2007-01), p. 102-111
    Abstract: A new method has been developed for estimating the storage lengths of left-turn lanes at signalized intersections. To prevent lane overflow, the left-turn lane should be designed to have a length sufficient to store the longest expected queue. In this study, the left-turn queue length was estimated by considering two factors: (a) vehicles that arrive during the red phase and (b) the queue of vehicles carried over from previous cycles. A method based on the discrete-time Markov chain was applied to model the leftover queue length at the end of the green phase. A case study was provided to demonstrate the application of the proposed model. In the model evaluation, the estimated left-turn queue lengths were compared with field observations and estimates from other existing methods. The results showed that the proposed model significantly outperformed existing methods by providing more accurate estimates of the lengths of left-turn queues.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.3141/2023-11
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2403378-9
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  • 2
    Online Resource
    Online Resource
    Peer acceptance and self-perceptions of verbal and behavioural aggression and social withdrawal
    SAGE Publications ; 2005
    In:  International Journal of Behavioral Development Vol. 29, No. 1 ( 2005-01), p. 48-57
    Details
    In: International Journal of Behavioral Development, SAGE Publications, Vol. 29, No. 1 ( 2005-01), p. 48-57
    Abstract: This study presents a model of maladaptive social interactions that includes both behavioural and communication correlates of peer acceptance and self-perceived social competence. Tested in a sample of 377 Hong Kong secondary school students, verbal and nonverbal aggression contributed concurrently and longitudinally to peer acceptance. Communication avoidance was predictive only of self-perceived social competence but not of peer acceptance, whereas, as observed in Western children, social withdrawal negatively predicted peer acceptance and self-perceived social competency. These findings are presented in a discussion of the verbal and nonverbal involvement in defining aggression and social withdrawal in adolescent social interactions.
    Type of Medium: Online Resource
    ISSN: 0165-0254 , 1464-0651
    URL: Article
    DOI: 10.1080/01650250444000324
    RVK:
    CL 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 1466999-7
    detail.hit.zdb_id: 432118-2
    SSG: 5,2
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  • 3
    Online Resource
    Online Resource
    Analysis of Traffic Flow Characteristics on Ring Road Expressways in Beijing : Using Floating Car Data and Remote Traffic Microwave Sensor Data
    SAGE Publications ; 2009
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2124, No. 1 ( 2009-01), p. 178-185
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2124, No. 1 ( 2009-01), p. 178-185
    Abstract: The primary objective of this paper is to analyze traffic flow characteristics on ring road expressways in Beijing on the basis of floating car data (FCD) and remote traffic microwave sensors (RTMS) data. Traffic flow characteristics are studied in relation to lane use, the relationship between occupancy and density, relationship of flow–speed–density, and the relationship between FCD speed and RTMS speed. It is demonstrated that lane use characteristics on the basic sections of ring road expressways are similar to those of freeways, in which the average vehicle lengths in the median, center, and shoulder lanes are found to be approximately 5.78 m, 6.03 m, and 6.33 m, respectively. Further, the four essential parameters used to characterize the Van Aerde flow–speed–density relationship are calibrated and compared for the second, third, and fourth ring road expressways. Results indicate that the fourth ring road, which has the highest free-flow speed, speed-at-capacity, and capacity, has characteristics similar to those of typical freeways. Traffic flow characteristics observed on the second and third ring roads are roughly consistent with the Greenshields model. It is observed that the second ring road has the worst traffic conditions, followed by the third ring road, and that the basic sections of ring road expressways have better traffic conditions than the areas around the ramp junctions. Finally, a regression analysis is done to develop the relationship between FCD speed and RTMS speed. It is found that RTMS speed is slightly higher than FCD speed, with a difference of less than 6%.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.3141/2124-17
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2403378-9
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  • 4
    Online Resource
    Online Resource
    Lack of Effect of Ginkgo biloba on Voriconazole Pharmacokinetics in Chinese Volunteers Identified as CYP2C19 Poor and Extensive Metabolizers
    SAGE Publications ; 2009
    In:  Annals of Pharmacotherapy Vol. 43, No. 4 ( 2009-04), p. 726-731
    Details
    In: Annals of Pharmacotherapy, SAGE Publications, Vol. 43, No. 4 ( 2009-04), p. 726-731
    Abstract: Ginkgo biloba is one of the most popular herbal supplements in the world. The supplement has been shown to induce the enzymatic activity of CYP2C19, the main cytochrome P450 isozyme involved in voriconazole metabolism. Because this enzyme exhibits genetic polymorphism, the inductive effect was expected to be modulated by the CYP2C19 metabolizer status. Objective: To examine the possible effects of Ginkgo biloba as an inducer of CYP2C19 on single-dose pharmacokinetics of voriconazole in Chinese volunteers genotyped as either CVP2C19 extensive or poor metabolizers. Methods: Fourteen healthy, nonsmoking volunteers–7 CYP2C19 extensive metabolizers (2C19*1/2C19*1) and 7 poor metabolizers (2C19*2/2C19*2)–were selected to participate in this study. Pharmacokinetics of oral voriconazole 200 mg after administration of Ginkgo biloba 120 mg twice daily for 12 days were determined for up to 24 hours by liquid chromatography–electrospray tandem mass spectrometry in a 2-phase randomized crossover study with 4-week washout between phases. Results: For extensive metabolizers, the median value for voriconazole area under the plasma concentration–time curve from zero to infinity (AUC 0-00 ) was 5.17 μg•h/mL after administration of voriconazole alone and 4.28 μg•/mL after voriconazole with Ginkgo biloba (p 〉 0.05). The other pharmacokinetic parameters of voriconazole such as AUC 0-24 , time to reach maximum concentration, half-life, and apparent clearance also did not change significantly for extensive metabolizers in the presence of Ginkgo biloba. Pharmacokinetic parameters followed a similar pattern for poor metabolizers. Conclusions: The results suggest that 12 days of treatment with Ginkgo biloba did not significantly alter the single-dose pharmacokinetics of voriconazole in either CYP2C19 extensive or poor metabolizers. Therefore, the pharmacokinetic interactions between voriconazole and Ginkgo biloba may have limited clinical significance.
    Type of Medium: Online Resource
    ISSN: 1060-0280 , 1542-6270
    URL: Article
    DOI: 10.1345/aph.1L537
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2053518-1
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    Human Multipotent Mesenchymal Stromal Cells from Fetal Lung Expressing Pluripotent Markers and Differentiating into Cell Types of Three Germ Layers
    SAGE Publications ; 2009
    In:  Cell Transplantation Vol. 18, No. 10-11 ( 2009-11), p. 1093-1109
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 18, No. 10-11 ( 2009-11), p. 1093-1109
    Abstract: Multipotent mesenchymal stromal cells (MSCs) are a promising cell type for cell transplantation; however, their utilization remains limited until the availability of adequate alternative sources of MSCs and the thorough understanding of the biology of MSCs isolated from various sources are realized. Fetal lung has been identified as a rich source of MSCs. To explore the therapeutic potential of passaged fetal lung MSCs (FLMSCs), the present study evaluated their growth kinetics, telomere length, karyotype, immunophenotype, and the differentiation potential during in vitro expansion. FLMSCs could be easily amplified in vitro with no significant shorting of telomere length and had a normal karyotype. No significant differences between passage 5 or passage 25 were observed in the immunophenotype analysis using flow cytometry. Moreover, flow cytometry results provided the first demonstration, to our knowledge, that FLMSCs stably expressed pluripotent markers including Oct4, Nanog, Sox2, TRA-1-60, c-Myc, and SSEA-4 through 25 passages. In vitro differentiation studies as identified by confocal microscopy, flow cytometry, RT-PCR, and immunohistochemistry showed that FLMSCs had extended capacity of differentiating into mesodermal, ectodermal, and endodermal lineages, and that their potential for adipogenic, osteogenic, and chondrogenic differentiation may be maintained over 25 passages. Furthermore, osteogenic and chondrogenic differentiation was used as an indicator of their differentiation capability in vivo, as evidenced by ectopic bone and cartilage formation. In summary, these results suggest that FLMSCs are a primitive population and that their extensive in vitro expansion does not involve significant functional modification of the cells, including morphology, growth, karyotype, immunophenotype, and mesodermal differentiation potential. Hence, FLMSCs might constitute an attractive cell resource for cell transplantation to induce regeneration of damaged tissues/organs.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368909X12483162197042
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2020466-8
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  • 6
    Online Resource
    Online Resource
    Composite disturbance-observer-based control and variable structure control for non-linear systems with disturbances
    SAGE Publications ; 2009
    In:  Transactions of the Institute of Measurement and Control Vol. 31, No. 5 ( 2009-10), p. 401-423
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 31, No. 5 ( 2009-10), p. 401-423
    Abstract: A novel type of control scheme combining the disturbance-observer-based control (DOBC) with variable structure control (VSC) is proposed for a class of continuous non-linear systems subject to disturbances. The disturbances are supposed to include two parts. One in the input channel is generated by an exogenous system with uncertainty, which can represent the harmonic signals with modelling perturbations. The other is supposed to have the bounded H 2 norm. The disturbance observers based on regional pole placement and D-stability theory are presented, which can be designed separately from the controller design. By integrating DOBC with VSC laws, the disturbances can be rejected and the desired dynamic performances can be guaranteed for continuous systems in finite time with known and unknown non-linear dynamics, respectively. Simulations for a flight control system are given to demonstrate the effectiveness of the results and compare the proposed results with the previous schemes.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1177/0142331208099282
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2025882-3
    SSG: 3,2
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  • 7
    Online Resource
    Online Resource
    Effects of Ginkgo biloba Extract Ingestion on the Pharmacokinetics of Talinolol in Healthy Chinese Volunteers
    SAGE Publications ; 2009
    In:  Annals of Pharmacotherapy Vol. 43, No. 5 ( 2009-05), p. 944-949
    Details
    In: Annals of Pharmacotherapy, SAGE Publications, Vol. 43, No. 5 ( 2009-05), p. 944-949
    Abstract: Ginkgo biloba extract (GBE), the best selling herbal medicine in the world, has been reported to inhibit P-glycoprotein in vitro. However, the effects of GBE on P-glycoprotein activity in humans have not been clarified. Objective To investigate the effects of single and repeated GBE ingestion on the oral pharmacokinetics of talinolol, a substrate drug for P-glycoprotein in humans. Methods Ten unrelated healthy male volunteers were selected to participate in a 3-stage sequential study. Plasma concentrations of talinolol from 0 to 24 hours were measured by high-performance liquid chromatography after talinolol 100 mg was administrated alone, with a single oral dose of GBE (120 mg), and after 14 days of repeated GBE ingestion (360 mg/day). Results A single oral dose of GBE did not affect the pharmacokinetics of talinolol. Repeated ingestion of GBE increased the talinolol maximum plasma concentration (C max ) by 36% (90% CI 10 to 68; p = 0.025), the area under the concentration-time curve (AUC) 0-24 by 26% (90% CI 11 to 43; p = 0.008) and AUC 0-∞ by 22% (90% CI 8 to 37; p = 0.014), respectively, without significant changes in elimination half-life and the time to C max . Conclusions Our results suggest that long-term use of GBE significantly influenced talinolol disposition in humans, likely by affecting the activity of P-glycoprotein and/or other drug transporters.
    Type of Medium: Online Resource
    ISSN: 1060-0280 , 1542-6270
    URL: Article
    DOI: 10.1345/aph.1L656
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2053518-1
    SSG: 15,3
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  • 8
    Online Resource
    Online Resource
    Routing Algorithms Based on Partial Deployment of SAVA Nodes in Trustworthy Internet
    SAGE Publications ; 2009
    In:  International Journal of Distributed Sensor Networks Vol. 5, No. 1 ( 2009-01-01), p. 34-34
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 5, No. 1 ( 2009-01-01), p. 34-34
    Abstract: Although the fundamental principles of best-effort and destination address based packet forwarding in today's Internet have brought tremendous convenience, the trustworthy issue in Internet is a hot problem since the lack of source IP address checking in most cases makes it easy for the attackers to spoof the source address. Therefore, one challenge in trustworthy Internet is to build a feasible mechanism to verify the source address. Recently, a feasible mechanism called Source Address Validation Architecture (SAVA) has been proposed to specify standardization of methods for building effective source-address validation to ensure that packets forwarded hold authentic source addresses. In SAVA mechanism, if a packet has been recognized as a spoofed source address, it will be dropped by the SAVA router and not be transmitted to the next hop. In our work, we study the routing algorithms based on partial deployment of SAVA nodes in Internet and propose three kinds of routing algorithms, i.e., Shortest-Path Algorithm (SPA), SAVA based Shortest-Path Algorithm (SSPA), and SAVA based Shortest-Path Algorithm with Load Balancing (SSPALB). To the best of our best knowledge, this is the first investigation for SAVA mechanism from the point of routing method. In SPA, the packet will be routed on the shortest path that may not traverse the SAVA node, and then the SAVA requirement may not be ensured. In SSPA, the packet will be routed on the shortest path that must traverse one SAVA node such that the SAVA requirement can be ensured. In SSPALB, the packet will be routed on the shortest path that must traverse one SAVA node at the same time this SAVA node must be the least-load such that the SAVA requirement can be ensured and the load can be more balancing. We simulate an incremental traffic model for the three kinds of routing algorithms to compare the performances of SAVA Satisfactory Degree (SSD) and Load Balancing (LB). Simulation results show that: the SSDs of SSPA and SSPALB can reach 100% while the SSD of SPA is only 20%-30%, which means that SSPA and SSPALB are completely satisfactory for SAVA requirements but SPA cannot; the LB of SSPALB can reach 100% while the LBs of SPA and SSPA are only 70%-80%, which means that SSPALB is more favorable for the load balancing.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1080/15501320802524003
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2192922-1
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  • 9
    Online Resource
    Online Resource
    Serum prolactin levels, plasma risperidone levels, polymorphism of cytochrome P450 2D6 and clinical response in patients with schizophrenia
    SAGE Publications ; 2007
    In:  Journal of Psychopharmacology Vol. 21, No. 8 ( 2007-11), p. 837-842
    Details
    In: Journal of Psychopharmacology, SAGE Publications, Vol. 21, No. 8 ( 2007-11), p. 837-842
    Abstract: The object of this study is to assess 1) the relationship between plasma antipsychotic drug concentration, serum prolactin levels and the clinical efficacy of risperidone, 2) the relationship between the CYP2D6 polymorphisms and metabolizing of risperidone and 3) the role of 9-hydroxyrisperidone in elevating prolactin levels. One-hundred and eighteen Chinese schizophrenia patients (40 males, 78 females, age 15—60 years) were given risperidone at dosages ranging from 2—8 mg/day for 8 weeks. Clinical efficacy was determined using the Brief Psychiatric Rating Scores (BPRS). Serum prolactin levels were assayed before and after the 8 week treatment and plasma risperidone and 9-hydroxyrisperidone levels were also measured at the end of the 8-week treatment. The results showed there was no significant correlation between the concentration of active moiety and clinical response. Risperidone treatment significantly increased serum prolactin levels. Furthermore, changes of prolactin levels were not correlated with the clinical response. For the risperidone/ 9-hydroxyrisperidone ratio, there was a statistically significant difference among the CYP2D6*1/*1, *1/*10, *10/*10 genotypes (Kruskal—Wallis test, p = 0.012). No significant differences were found in the concentration of 9-hydroxyrisperidone and active moiety among the genotypes. In addition, the concentration of 9-hydroxyrisperidone was not significantly correlated with the increase of serum prolactin. In conclusion, our study has, for the first time, produced evidence that in Chinese schizophrenic patients, the metabolism of risperidone is dependent on CYP2D6. Neither changes in serum prolactin levels nor plasma concentration of active moiety were significantly correlated with clinical efficacy of risperidone. 9-hydroxyrisperidone may not play a predominant role in elevating serum prolactin level.
    Type of Medium: Online Resource
    ISSN: 0269-8811 , 1461-7285
    URL: Article
    DOI: 10.1177/0269881107077357
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2028926-1
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  • 10
    Online Resource
    Online Resource
    Aerospace Advances — An Introduction
    SAGE Publications ; 2008
    In:  Measurement and Control Vol. 41, No. 3 ( 2008-04), p. 76-76
    Details
    In: Measurement and Control, SAGE Publications, Vol. 41, No. 3 ( 2008-04), p. 76-76
    Type of Medium: Online Resource
    ISSN: 0020-2940
    URL: Article
    DOI: 10.1177/002029400804100301
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2008
    detail.hit.zdb_id: 2712343-1
    SSG: 3,2
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