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  • SAGE Publications  (38)
  • 2005-2009  (38)
  • 1
    Online Resource
    Online Resource
    Inactivation of the p16 Cyclin-Dependent Kinase Inhibitor in High-Grade Canine Non-Hodgkin's T-Cell Lymphoma
    SAGE Publications ; 2007
    In:  Veterinary Pathology Vol. 44, No. 4 ( 2007-07), p. 467-478
    Details
    In: Veterinary Pathology, SAGE Publications, Vol. 44, No. 4 ( 2007-07), p. 467-478
    Abstract: The significance of p16/Rb tumor suppressor pathway inactivation in T-cell non-Hodgkin's lymphoma (NHL) remains incompletely understood. We used naturally occurring canine NHL to test the hypothesis that p16 inactivation has specific pathologic correlates. Forty-eight samples (22 T-cell NHL and 26 B-cell NHL) were included. As applicable, metaphase- or array-based comparative genomic hybridization, Southern blotting, promoter methylation, and Rb phosphorylation were used to determine the presence, expression, and activity of p16. Fisher's exact test was used to test for significance. Deletion of p16 (or loss of dog chromosome 11) was restricted to high-grade T-cell NHL (lymphoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified). These were characterized by a concomitant increase of tumor cells with Rb phosphorylation at canonical CDK4 sites. Rb phosphorylation also was seen in high-grade B-cell NHL (diffuse large B-cell lymphoma and Burkitt-type lymphoma), but in those cases, it appeared to be associated with c-Myc overexpression. The data show that p16 deletion or inactivation occurs almost exclusively in high-grade T-cell NHL; however, alternative pathways can generate functional phenotypes of Rb deficiency in low-grade T-cell NHL and in high-grade B-cell NHL. Both morphologic classification according to World Health Organization criteria and assessment of Rb phosphorylation are prognostically valuable parameters for canine NHL.
    Type of Medium: Online Resource
    ISSN: 0300-9858 , 1544-2217
    URL: Article
    DOI: 10.1354/vp.44-4-467
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2106608-5
    SSG: 22
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  • 2
    Online Resource
    Online Resource
    Attitudes of breast cancer professionals to conventional and telemedicine-delivered multidisciplinary breast meetings
    SAGE Publications ; 2005
    In:  Journal of Telemedicine and Telecare Vol. 11, No. 2_suppl ( 2005-12), p. 29-34
    Details
    In: Journal of Telemedicine and Telecare, SAGE Publications, Vol. 11, No. 2_suppl ( 2005-12), p. 29-34
    Type of Medium: Online Resource
    ISSN: 1357-633X , 1758-1109
    URL: Article
    DOI: 10.1258/135763305775124812
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 2007700-2
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  • 3
    Online Resource
    Online Resource
    A comprehensive approach for evaluating telemedicine-delivered multidisciplinary breast cancer meetings in southern Scotland
    SAGE Publications ; 2005
    In:  Journal of Telemedicine and Telecare Vol. 11, No. 1_suppl ( 2005-07), p. 71-73
    Details
    In: Journal of Telemedicine and Telecare, SAGE Publications, Vol. 11, No. 1_suppl ( 2005-07), p. 71-73
    Abstract: Multidisciplinary team (MDT) meetings for decisions on cancer management are a cornerstone of UK cancer policy. We have proposed a comprehensive methodology to assess the clinical and economic effectiveness of telemedicine in this setting, which is being tested in a randomized breast cancer trial. Pre- and post-telemedicine assessment includes attitudes to and expectations of telemedicine, based on semistructured interviews. The communication content of videotapes of the MDT meeting is being scored using Borgatta's revised Interaction Process Analysis System. The technical performance of the telemedicine equipment is reported on a standardized pro forma. A short questionnaire captures key elements of professional satisfaction for each patient discussion (consensus on future management, confidence in and sharing of decision), added value of linkage, group atmosphere, overall conduct of the meeting and compliance with SIGN guidelines. A cost-minimization analysis will be used for economic assessment.
    Type of Medium: Online Resource
    ISSN: 1357-633X , 1758-1109
    URL: Article
    DOI: 10.1258/1357633054461804
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 2007700-2
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  • 4
    Online Resource
    Online Resource
    Ellis—van Creveld Syndrome
    SAGE Publications ; 2006
    In:  Journal of Diagnostic Medical Sonography Vol. 22, No. 2 ( 2006-03), p. 111-116
    Details
    In: Journal of Diagnostic Medical Sonography, SAGE Publications, Vol. 22, No. 2 ( 2006-03), p. 111-116
    Abstract: Ellis—van Creveld syndrome is a rare, singlegene genetic congenital skeletal disorder. It is an autosomal recessive inherited disorder, which means that both parents must carry the gene for the child to be affected. It involves abnormalities of multiple body systems, including teeth, nails, hair, lungs, and liver, and approximately 50% of affected patients will have major heart defects. There is short-limbed dwarfism, with the extremities being disproportionate with the trunk, this being more apparent in the lower limbs. Postaxial polydactyly, or extra digits in the hands, is seen in virtually 100% of those individuals affected with Ellis—van Creveld. Despite the advances in sonography, the prenatal diagnosis of a specific skeletal dysplasia remains very difficult and often can only be made after birth or termination of the pregnancy.
    Type of Medium: Online Resource
    ISSN: 8756-4793 , 1552-5430
    URL: Article
    DOI: 10.1177/8756479306287418
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2040352-5
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  • 5
    Online Resource
    Online Resource
    Effect of accommodating sucking and nosing on the behaviour of artificially reared piglets
    SAGE Publications ; 2005
    In:  Laboratory Animals Vol. 39, No. 2 ( 2005-04-01), p. 240-250
    Details
    In: Laboratory Animals, SAGE Publications, Vol. 39, No. 2 ( 2005-04-01), p. 240-250
    Abstract: Neonatal piglets are often used in biomedical research applications that require artificial rearing. Social housing can be problematic because the piglets develop belly nosing, navel and ear sucking that can result in injury. Our objective was to determine the effectiveness of using feeding devices that provide various opportunities for sucking and nosing behaviour on reducing piglet-directed behaviour of group-housed laboratory piglets. Fifteen piglets were used in each of four trials. The piglets nursed their dam for approximately 72 h to obtain passive immunity before transfer to a laboratory facility where they were allotted, five per group, to one of three stainless steel isolator units. Each unit featured a different style of feeding system for the delivery of milk replacer: a plastic trough (T), a nipple (N) mounted on a smooth plexiglass wall, or a nipple mounted on a pliant bag of sterile water (artificial udder [AU] ). Each system had five feeding spaces so that all piglets fed simultaneously. Milk was provided at 6-h intervals, and behaviour was recorded on alternate days for 12 days post-weaning. Although trough-fed piglets began to eat much sooner than those piglets fed from nipples, time spent nosing, chewing or sucking on pen-mates and belly nosing were markedly higher in T piglets than in either N or AU, overall (mean: P 〈 0.05) and over time (quadratic: P 〈 0.05). Over time, N piglets developed a stereotypic snout rubbing on the wall behind the nipples, while AU piglets massaged and often fell asleep in contact with the udder from day 2 of the trial. Resting patterns were also affected. N and AU piglets settled down to rest more quickly (P 〈 0.01) and spent significantly more time resting in the hour following feeding than T piglets (P 〈 0.05). A feeding device that accommodates both sucking and massage can significantly reduce piglet-directed behaviour and may facilitate social housing of artificially reared piglets.
    Type of Medium: Online Resource
    ISSN: 0023-6772 , 1758-1117
    URL: Article
    DOI: 10.1258/0023677053739701
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 2036511-1
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  • 6
    Online Resource
    Online Resource
    RESULTS OF POST-KATRINA NEEDS ASSESSMENT FOR PATIENTS WITH SICKLE CELL DISEASE AND CANCER. : 127
    SAGE Publications ; 2007
    In:  Journal of Investigative Medicine Vol. 55, No. 1 ( 2007-01), p. S267-
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 55, No. 1 ( 2007-01), p. S267-
    Type of Medium: Online Resource
    ISSN: 1081-5589
    URL: Article
    DOI: 10.1097/00042871-200701010-00641
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
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  • 7
    Online Resource
    Online Resource
    Nasoseptal Flap Reconstruction of High Flow Intraoperative Cerebral Spinal Fluid Leaks during Endoscopic Skull Base Surgery
    SAGE Publications ; 2009
    In:  American Journal of Rhinology & Allergy Vol. 23, No. 5 ( 2009-09), p. 518-521
    Details
    In: American Journal of Rhinology & Allergy, SAGE Publications, Vol. 23, No. 5 ( 2009-09), p. 518-521
    Abstract: Over the past 10 years, significant anatomic, technical, and instrumentation advances have facilitated the exposure and resection of intradural lesions via a fully endoscopic expanded endonasal approach (EEA). The vascularized nasoseptal flap (based on the posterior nasoseptal artery) has become our primary endoscopic reconstructive technique. The goals of this study are to prospectively evaluate the nasoseptal flap and high-risk cerebral spinal fluid (CSF) leak variables. Methods Prospective evaluation was performed of EEA patients with intraoperative high-flow leaks (either a cistern or ventricle open to nasal cavity during tumor dissection) who underwent nasoseptal flap reconstruction. Results Seventy consecutive nasoseptal flaps for high-flow intraoperative leaks were evaluated prospectively by the primary author. Twelve risk factors were then graded at the time of the operations and correlated to CSF leak outcomes. The overall postoperative CSF leak rate was 5.7% (4/70). All four postoperative leaks were successfully managed with endoscopic repair and CSF diversion. A multivariate analysis of all 12 risk factors is detailed. Pediatric patients, large dural defects, and radiation therapy were noted to be factors in reconstructive failure. One flap death occurred in a patient with prior surgery and proton therapy, this leak was managed with a temporoparietal flap and endonasal repair. Conclusion The nasoseptal flap is an excellent anterior skull base reconstructive technique. Patients with high-flow intraoperative CSF leaks had a 94% successful reconstruction rate. Patients with skull base proton radiation therapy are at higher risk for flap failure and preparation for nonradiated tissue reconstruction should be discussed with the patient.
    Type of Medium: Online Resource
    ISSN: 1945-8924 , 1945-8932
    URL: Article
    DOI: 10.2500/ajra.2009.23.3378
    RVK:
    XA 20278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2554548-6
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  • 8
    Online Resource
    Online Resource
    Modelling and test results of the Archimedes wave swing
    SAGE Publications ; 2006
    In:  Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy Vol. 220, No. 8 ( 2006-12-01), p. 855-868
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy, SAGE Publications, Vol. 220, No. 8 ( 2006-12-01), p. 855-868
    Abstract: The objective of this paper is to describe the modelling and some of the offshore test results of the full-scale model of Archimedes wave swing (AWS) at Portugal in 2004. The AWS is a system that converts ocean wave energy into electric energy. A pilot plant of this system has been built. The paper starts with the derivation of a model for the floater motion. Next, the generator system is described and modelled. The generator system consists of a permanent-magnet linear synchronous generator with a current source inverter. Subsequently, test results are presented to validate the models for the floater motion and the generator. Finally, some conclusions are drawn.
    Type of Medium: Online Resource
    ISSN: 0957-6509 , 2041-2967
    URL: Article
    DOI: 10.1243/09576509JPE284
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2024892-1
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  • 9
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    Online Resource
    Mimosa tenuiflora as a Cause of Malformations in Ruminants in the Northeastern Brazilian Semiarid Rangelands
    SAGE Publications ; 2007
    In:  Veterinary Pathology Vol. 44, No. 6 ( 2007-11), p. 928-931
    Details
    In: Veterinary Pathology, SAGE Publications, Vol. 44, No. 6 ( 2007-11), p. 928-931
    Abstract: Craniofacial anomalies, eye malformations, and permanent flexures of the forelimbs are common malformations seen in ruminants grazing semiarid rangelands of Northeastern Brazil. To investigate the cause of these malformations, we fed 2 suspected plants, Mimosa tenuiflora or Prosopis juliflora, to groups of 4 pregnant goats each. Fresh green M. tenuiflora was collected daily and fed ad libitum to 4 goats in group 1 throughout pregnancy. This treatment group also received a supplemental feed concentrate equivalent to 1% body weight. Four goats in group 2 received a ration with 70% of P. juliflora pods and 30% hay throughout pregnancy. Four control goats were fed supplemental feed concentrate (1% body weight) and hay ad libitum throughout pregnancy. Goats treated with P. juliflora pods and the control goats delivered 9 normal kids. The four goats that were fed M. tenuiflora during pregnancy delivered 4 kids, 3 of which had abnormalities similar to those observed in field cases, including cleft lip, unilateral corneal opacity, ocular bilateral dermoids, buphthalmos with a cloudy brownish appearance of the anterior chamber due to an iridal cyst, and segmental stenosis of the colon. Malformations induced experimentally by M. tenuiflora were similar to those observed in field cases, suggesting that M. tenuiflora is a cause of the field cases observed in the Brazilian semiarid rangelands.
    Type of Medium: Online Resource
    ISSN: 0300-9858 , 1544-2217
    URL: Article
    DOI: 10.1354/vp.44-6-928
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 2106608-5
    SSG: 22
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  • 10
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    Online Resource
    Body-Image Perception and Dissatisfaction Throughout Phases of the Female Menstrual Cycle
    SAGE Publications ; 2009
    In:  Perceptual and Motor Skills Vol. 108, No. 1 ( 2009-02), p. 74-80
    Details
    In: Perceptual and Motor Skills, SAGE Publications, Vol. 108, No. 1 ( 2009-02), p. 74-80
    Abstract: This pilot study investigated the association between the menstrual cycle and participants' body-size perception, judgments of ideal body size, detection of changes in body size, and body dissatisfaction. Thirty participants ( M age = 23.3 yr., SD = 3.9), who did not have eating disorders, viewed digital images of their bodies. Judgments on all tasks were made during premenstrual, intermenstrual, and menstrual phases of the menstrual cycle. Participants expressed a desire for a smaller ideal body size for themselves in all three phases. Body dissatisfaction was significantly greater during the premenstrual and menstrual phases. The menstrual cycle was not associated with significant changes in body-size perception, ideal size judgments, or detection of changes in body size.
    Type of Medium: Online Resource
    ISSN: 0031-5125 , 1558-688X
    URL: Article
    DOI: 10.2466/pms.108.1.74-80
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2066876-4
    SSG: 5,2
    SSG: 7,11
    SSG: 31
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