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  • S. Karger AG  (9)
  • 2005-2009  (9)
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  • S. Karger AG  (9)
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  • 2005-2009  (9)
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  • 1
    Online Resource
    Online Resource
    Imatinib Mesylate Resistance in a Chronic Myeloid Leukemia Patient with a Novel e8a2 BCR-ABL Transcript Variant
    S. Karger AG ; 2008
    In:  Acta Haematologica Vol. 120, No. 3 ( 2008), p. 146-149
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 120, No. 3 ( 2008), p. 146-149
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The vast majority of chronic myeloid leukemia (CML) patients express the BCR-ABL transcript with the b2a2 (e13a2) and/or b3a2 (e14a2) junctions. However, some rare cases have atypical breakpoints. 〈 i 〉 Methods and Results: 〈 /i 〉 We identified a CML patient with a unique e8a2 BCR-ABL transcript variant. It contained the first 114 nucleotides of BCR exon 8, with an insertion of 16 nucleotides from the 3′ end of ABL intron 1a, followed by ABL exon 2. Due to her uncontrolled thrombocytosis after 3 years of interferon-α treatment, the patient received imatinib at a dosage of 400 mg/day. Though achieving a sustained and complete hematological response after 3 months, she was resistant to imatinib during the entire 65-month imatinib treatment. That is, she failed to achieve major cytogenetic response and there was no significant decrease in her BCR-ABL transcript levels. Meanwhile, an M351T mutant was detected at 18 months after the start of imatinib treatment. 〈 i 〉 Conclusion: 〈 /i 〉 ABL point mutation is also a mechanism of imatinib resistance for CML patients with the BCR-ABL transcript variant.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000178145
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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  • 2
    Online Resource
    Online Resource
    Pre-Stroke Use of Antihypertensives, Antiplatelets, or Statins and Early Ischemic Stroke Outcomes
    S. Karger AG ; 2009
    In:  Cerebrovascular Diseases Vol. 27, No. 4 ( 2009), p. 398-402
    Details
    In: Cerebrovascular Diseases, S. Karger AG, Vol. 27, No. 4 ( 2009), p. 398-402
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The effect of pre-stroke use of antihypertensives, antiplatelets, and statins on initial severity and early outcome of ischemic stroke is uncertain. 〈 i 〉 Methods: 〈 /i 〉 We performed a retrospective chart review of 553 consecutive acute ischemic stroke patients presenting to the Montreal General Hospital between April 1st 2002 and October 15th 2005. We defined a severe stroke as a Canadian Neurological Scale score of ≤7 and a poor early outcome as a modified Rankin Scale score of 〉 3 at 10 days post-stroke. 〈 i 〉 Results: 〈 /i 〉 In total, 339 patients were included. Superior early functional outcome was associated with the premorbid use of statins (OR = 0.50, 95% CI: 0.25–1.00) and the combination of all 3 medications (OR = 0.37, 95% CI: 0.16–0.87). Angiotensin-II-decreasing agents were associated with an increased risk of severe strokes (OR = 2.13, 95% CI: 1.00–4.52). 〈 i 〉 Conclusions: 〈 /i 〉 Pre-stroke use of statins and the combination of antihypertensives, antiplatelets, and statins were both associated with a favorable functional outcome at 10 days post-stroke. Angiotensin-II-decreasing agents were associated with increased initial stroke severity.
    Type of Medium: Online Resource
    ISSN: 1015-9770 , 1421-9786
    URL: Article
    DOI: 10.1159/000207444
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 1482069-9
    detail.hit.zdb_id: 1069462-6
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  • 3
    Online Resource
    Online Resource
    Blood Pressure and Antihypertensive Therapy as Predictors of Early Outcome in Acute Ischemic Stroke
    S. Karger AG ; 2008
    In:  Cerebrovascular Diseases Vol. 25, No. 3 ( 2008), p. 202-208
    Details
    In: Cerebrovascular Diseases, S. Karger AG, Vol. 25, No. 3 ( 2008), p. 202-208
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The clinical impact of blood pressure (BP) and of antihypertensive therapy (AHT) in acute ischemic stroke remains uncertain. 〈 i 〉 Methods: 〈 /i 〉 We reviewed the charts of patients admitted to the Montreal General Hospital between April 1, 2002 and October 15, 2005. Ischemic stroke was considered severe if the Canadian Neurological Scale at presentation was ≤7. Poor outcome at 10 days after onset was defined as a modified Rankin Scale 〉 3. Acute change in BP was defined as the percent difference between the mean 24-hour mean arterial pressure (MAP) and the baseline MAP. AHT was considered present if administered ≧5 days during the first week after stroke onset. The association between predictors and outcome was assessed using unconditional multivariable logistic regression. Covariates used included age, stroke severity, diabetes mellitus, coronary artery disease, atrial fibrillation, premorbid hypertension and hyperlipidemia. 〈 i 〉 Results: 〈 /i 〉 Three hundred and sixty-four patients were included. Compared to patients with intermediate baseline BP, those with a MAP 〉 130 mm Hg [OR = 2.47 (95% CI, 1.04–5.85)] 〈 i 〉 or 〈 /i 〉 a MAP 〈 90 mm Hg [OR = 2.94 (95% CI, 1.28–6.77)] were found to have an increased risk of poor outcome after covariate adjustment. A 15% increase in MAP was associated with an increased risk of poor outcome [OR = 5.34 (95% CI, 1.18–24.3)] while AHT in the first week after stroke onset was found to result in a decreased risk [OR = 0.39 (95% CI, 0.17–0.90)]. However, neither of these findings remained significant after adjustment for the described covariates. 〈 i 〉 Conclusions: 〈 /i 〉 Both high 〈 i 〉 and 〈 /i 〉 low MAP at presentation are associated with worse short-term outcome after ischemic stroke.
    Type of Medium: Online Resource
    ISSN: 1015-9770 , 1421-9786
    URL: Article
    DOI: 10.1159/000113857
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1482069-9
    detail.hit.zdb_id: 1069462-6
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  • 4
    Online Resource
    Online Resource
    Effects of Simvastatin on Oxidative Stress in Streptozotocin-Induced Diabetic Rats: A Role for Glomeruli Protection
    S. Karger AG ; 2005
    In:  Nephron Experimental Nephrology Vol. 101, No. 1 ( 2005-5-11), p. e1-e8
    Details
    In: Nephron Experimental Nephrology, S. Karger AG, Vol. 101, No. 1 ( 2005-5-11), p. e1-e8
    Abstract: 〈 i 〉 Aims: 〈 /i 〉 To study the effects of simvastatin on oxidative stress in rats with early stage diabetic nephropathy. 〈 i 〉 Methods: 〈 /i 〉 60 male Sprague-Dawley rats were divided into three groups: control group (CN), streptozotocin (STZ)-induced diabetic rats group (DM) and STZ-induced diabetic rats group treated with simvastatin (DM+S). The following parameters were measured at weeks 6 and 12 in similar rats chosen randomly from each group: body and kidney weight, 24-hour urinary albumin excretion (UAE), biochemical indexes including blood glucose (GLU), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), serum creatinine (SCr), antioxidant enzymes including superoxide dismutase (SOD), glutathione S-transferase (GST), catalase (CAT) in plasma, lipid peroxidation production as malondialdehyde in plasma (MDAp) and erythrocytes (MDAe), morphology parameters such as glomerular volume (GV) and mesangial area/total glomerular area (M/T). 〈 i 〉 Results: 〈 /i 〉 At weeks 6 and 12, GLU and kidney weight to body weight ratio were notably increased in both of the diabetic groups compared with those in the CN group without significant differences between the two diabetic groups. There were no significant differences of SCr, LDL, HDL and TG among all groups within all the experimental time. MDAp and MDAe were significantly increased in both of the diabetic groups, especially at week 12, while SOD, GST and CAT were significantly decreased compared with those in the CN group. At week 12, GV, M/T and UAE were also increased in the two diabetic groups. However, in the DM+S group, changes of lipid peroxidation production, antioxidant enzymes, UAE and GV were less pronounced than those in the DM group. Pearson’s correlation analysis and regression analysis shown that MDAp was increased while SOD, GST and CAT in plasma were decreased with elevation of UAE, GV and M/T. 〈 i 〉 Conclusion: 〈 /i 〉 Increased lipid peroxidation and decreased antioxidant enzymes in plasma may play a role in the progression of diabetic nephropathy. Simvastatin may ameliorate these changes to protect kidney from oxidative lesion in diabetes even in the absence of lipid abnormalities.
    Type of Medium: Online Resource
    ISSN: 1660-2129
    URL: Article
    DOI: 10.1159/000085712
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 2098337-2
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  • 5
    Online Resource
    Online Resource
    Cerebellar Fastigial Nuclear Inputs and Peripheral Feeding Signals Converge on Neurons in the Dorsomedial Hypothalamic Nucleus
    S. Karger AG ; 2009
    In:  Neurosignals Vol. 17, No. 2 ( 2009), p. 132-143
    Details
    In: Neurosignals, S. Karger AG, Vol. 17, No. 2 ( 2009), p. 132-143
    Type of Medium: Online Resource
    ISSN: 1424-862X , 1424-8638
    URL: Article
    DOI: 10.1159/000197913
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 2074039-6
    detail.hit.zdb_id: 2061922-4
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Inhibition of CD8+ T Lymphocytes Attenuates Respiratory Syncytial Virus-Enhanced Allergic Inflammation
    S. Karger AG ; 2009
    In:  Respiration Vol. 77, No. 1 ( 2009), p. 76-84
    Details
    In: Respiration, S. Karger AG, Vol. 77, No. 1 ( 2009), p. 76-84
    Abstract: 〈 i 〉 Background: 〈 /i 〉 CD8+ T cells have an important role in the pathogenesis of respiratory virus-induced asthma exacerbations. However, the cellular mechanism of CD8+ T cells, linking viral respiratory infections to the development of airway inflammation, is not well defined. 〈 i 〉 Objectives: 〈 /i 〉 To clarify the role of CD8+ T cells in the development of respiratory virus-induced asthma exacerbations. 〈 i 〉 Methods: 〈 /i 〉 Using a murine model of prior ovalbumin exposure and subsequent respiratory syncytial virus infection, the airway responsiveness was assessed by barometric whole-body plethysmography. Airway eosinophils, lymphocytes, neutrophils as well as IFN-γ, IL-4, IL-5 and IL-13 in bronchoalveolar lavage fluid were measured by Diff-Quick staining and ELISA. The frequency of cytokine-producing CD8+ T lymphocytes in peribronchial lymph nodes was detected using 2-color immunofluorescence analysis. Histological examinations were carried out using hematoxylin and eosin and immunohistochemistry. 〈 i 〉 Results: 〈 /i 〉 Anti-CD8 monoclonal antibody (1 mg/kg) clearly inhibited increases in airway responsiveness to acetylcholine and markedly reduced the number of eosinophils, neutrophils, lymphocytes as well as IL-4, IL-5 and IL-13 levels in bronchoalveolar lavage fluid. Furthermore, the antibody also attenuated airway inflammation and CD8+ T lymphocyte infiltration in lung tissue. 〈 i 〉 Conclusions: 〈 /i 〉 These findings suggest that CD8+ T lymphocytes play a critical role for the development of respiratory syncytial virus-induced airway inflammation and airway hyperresponsiveness.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000158871
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 1464419-8
    detail.hit.zdb_id: 206674-9
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  • 7
    Online Resource
    Online Resource
    Moderate-Severe Renal Insufficiency Is a Risk Factor for Sirolimus-Eluting Stent Thrombosis
    S. Karger AG ; 2009
    In:  Cardiology Vol. 112, No. 3 ( 2009), p. 191-199
    Details
    In: Cardiology, S. Karger AG, Vol. 112, No. 3 ( 2009), p. 191-199
    Abstract: 〈 i 〉 Objective: 〈 /i 〉 The RIFT study aimed to observe the impact of renal insufficiency (RI) on the incidence of stent thrombosis (ST) after percutaneous coronary intervention. 〈 i 〉 Methods: 〈 /i 〉 The RIFT study enrolled 1,174 patients undergoing revascularization exclusively with sirolimus-eluting stents. The occurrence of ST and major adverse cardiac events were compared between patients with (n = 309) and without (n = 865) RI, and independent predictors of ST were also identified. 〈 i 〉 Results: 〈 /i 〉 During follow-up (mean 18.9 ± 9.2 months), the rate of ST was significantly higher in patients with than without RI [5.5% (n = 17) vs. 1.7% (n = 15), p 〈 0.001], and the presence of severe RI (estimated glomerular filtration rate 〈 30 ml/min·1.73 m 〈 sup 〉 2 〈 /sup 〉 ) was an independent predictor of ST (odds ratio = 4.5, 95% confidence interval 1.4–15, p = 0.011). In patients with RI and diabetes or left ventricular ejection fraction (LVEF) 〈 50%, the incidence of ST was significantly increased [13.0% (n = 10) vs. 3.6% (n = 7), p = 0.010; 11.6% (n = 8) vs. 1.9% (n = 3), p = 0.004, respectively] compared to those with diabetes or LVEF 〈 50% alone. The influence of RI on ST was not significant in patients with multivessel disease, calcified or bifurcation lesions, and target lesion revascularization. 〈 i 〉 Conclusions: 〈 /i 〉 These findings substantiate the importance of long-term antiplatelet therapy for patients with RI after drug-eluting stent implantation.
    Type of Medium: Online Resource
    ISSN: 0008-6312 , 1421-9751
    URL: Article
    DOI: 10.1159/000149571
    RVK:
    XA 36200
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 80092-2
    detail.hit.zdb_id: 1482041-9
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  • 8
    Online Resource
    Online Resource
    Epigenetic and Genetic Alterations of the 〈i〉EDNRB〈/i〉 Gene in Nasopharyngeal Carcinoma
    S. Karger AG ; 2007
    In:  Oncology Vol. 72, No. 5-6 ( 2007), p. 357-363
    Details
    In: Oncology, S. Karger AG, Vol. 72, No. 5-6 ( 2007), p. 357-363
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Loss of heterozygosity (LOH) at 13q22 is a common event in nasopharyngeal carcinoma (NPC). 〈 i 〉 EDNRB 〈 /i 〉 gene located at 13q22 has been demonstrated to be hypermethylated in some kinds of tumors. In the current study, we focused on the epigenetic and genetic alterations of 〈 i 〉 EDNRB 〈 /i 〉 in NPC. 〈 i 〉 Methods: 〈 /i 〉 The mRNA expression of 〈 i 〉 EDNRB 〈 /i 〉 was detected by semiquantitative RT-PCR and real-time quantitative PCR in 49 NPC and 12 chronic nasopharyngitis biopsies. The methylation and LOH status of 〈 i 〉 EDNRB 〈 /i 〉 were examined by methylation-specific polymerase chain reaction, microsatellite PCR and sequencing. We also examined the mRNA expression of 〈 i 〉 EDNRB 〈 /i 〉 in four NPC cell lines after 5-aza-2′-deoxycytidine treatment. 〈 i 〉 Results: 〈 /i 〉 〈 i 〉 EDNRB 〈 /i 〉 was downregulated in primary NPC tissues and NPC cell lines, and a relatively higher methylation level of 〈 i 〉 EDNRB 〈 /i 〉 was found in NPC biopsies (84%) compared to that in chronic nasopharyngitis biopsies (42%). Treatment of NPC cell lines with 5-aza-2′-deoxycytidine activated 〈 i 〉 EDNRB 〈 /i 〉 expression. LOH of 〈 i 〉 EDNRB 〈 /i 〉 gene was also found at two microsatellite sites with ratios of 6.25 and 16.67% in NPC. 〈 i 〉 Conclusion: 〈 /i 〉 Our results suggested that 〈 i 〉 EDNRB 〈 /i 〉 expression may be affected by aberrant promoter methylation and gene deletion and may play a role in the development of NPC.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000113146
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2007
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 9
    Online Resource
    Online Resource
    Hepatitis C Virus F Protein Up-Regulates c-myc and Down-Regulates p53 in Human Hepatoma HepG〈sub〉2〈/sub〉 Cells
    S. Karger AG ; 2007
    In:  Intervirology Vol. 50, No. 5 ( 2007), p. 341-346
    Details
    In: Intervirology, S. Karger AG, Vol. 50, No. 5 ( 2007), p. 341-346
    Abstract: 〈 i 〉 Objectives: 〈 /i 〉 Hepatitis C virus (HCV) F protein is a newly identified protein encoded by an alternative open reading frame that +1 overlaps core-encoding gene. It has been found that regulation of c-myc and p53 genes by HCV core protein is involved in liver cancer genesis. We wondered whether HCV F protein exerts similar or adverse regulatory effects on the transcription of c-myc and p53 genes. 〈 i 〉 Methods: 〈 /i 〉 HCV F gene-containing, plasmid pcDNA3.1-F and HCV core gene-containing pcDNA3.1-C were constructed and transiently transfected into HepG 〈 sub 〉 2 〈 /sub 〉 cells. Real-time quantitative PCR or Western blotting was used to determine the changes at transcription or translation levels of c-myc and p53 genes. 〈 i 〉 Results: 〈 /i 〉 The transcription level of c-myc was much higher in pcDNA3.1-F transfected cells than those without plasmid transfected. Whereas the level of p53 transcription in pcDNA3.1-F transfected cells was lower than those in the parental cells. Moreover, levels of c-myc expression were up-regulated and those of p53 expression were down-regulated by HCV F protein. 〈 i 〉 Conclusions: 〈 /i 〉 HCV F protein is of regulatory properties in cellular oncogene c-myc and anti-oncogene p53, which may be implicated in the formation of hepatocellular carcinoma.
    Type of Medium: Online Resource
    ISSN: 0300-5526 , 1423-0100
    URL: Article
    DOI: 10.1159/000107271
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2007
    detail.hit.zdb_id: 184545-7
    detail.hit.zdb_id: 1482863-7
    SSG: 12
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