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  • S. Karger AG  (4)
  • 2005-2009  (4)
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  • S. Karger AG  (4)
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  • 2005-2009  (4)
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Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Hepatitis C Virus Infection Can Present with Metabolic Disease by Inducing Insulin Resistance
    S. Karger AG ; 2006
    In:  Intervirology Vol. 49, No. 1-2 ( 2006), p. 51-57
    Details
    In: Intervirology, S. Karger AG, Vol. 49, No. 1-2 ( 2006), p. 51-57
    Abstract: Although hepatitis C virus (HCV) targets the liver, it has become increasingly evident that HCV can induce diseases of many organs. Recently, much attention is drawn to metabolic disorders in HCV infection. First, hepatic steatosis and derangement in lipid metabolism have been found characteristic of HCV infection, and later on, a correlation was noted between HCV infection and diabetes as well as insulin resistance. We have demonstrated that HCV by itself can induce insulin resistance through disturbing the insulin signaling pathway by HCV proteins. The fact that HCV infection induces insulin resistance by the virus itself may influence the progression of chronic liver disease and open up novel therapeutic approaches. In conclusion, towards the future, HCV infection needs to be viewed not only as a liver disease but also as a metabolic disease.
    Type of Medium: Online Resource
    ISSN: 0300-5526 , 1423-0100
    URL: Article
    DOI: 10.1159/000087263
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2006
    detail.hit.zdb_id: 1482863-7
    SSG: 12
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Relationship between Albuminuria, Low eGFR, and Carotid Atherosclerosis in Japanese Women
    S. Karger AG ; 2008
    In:  Kidney and Blood Pressure Research Vol. 31, No. 3 ( 2008), p. 164-170
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 31, No. 3 ( 2008), p. 164-170
    Abstract: In this cross-sectional study, we have investigated whether chronic kidney disease components were associated with carotid plaque and carotid intima-media thickening in women. Between April 2005 and May 2006, 830 women underwent general health screening including carotid ultrasonography and urinary albumin excretion, and were enrolled in the study. Of these individuals examined, 83 (10%) had albuminuria, 203 (24%) had low estimated GFR (eGFR), and 24 (3%) had both albuminuria and low eGFR. Univariate analysis showed that albuminuria, but not low eGFR, was associated with carotid plaque, and that both albuminuria and low eGFR were positively associated with carotid intima-media thickening. Age-adjusted logistic regression analysis showed that albuminuria was positively associated with carotid plaque with an odds ratio of 2.48 (95% CI 1.49–4.11, p 〈 0.001). On the other hand, association between albuminuria and carotid intima-media thickening was not statistically significant after age adjustment. Positive association between albuminuria and carotid plaque was present when either hypertension or high fasting glucose was absent. In conclusion, in Japanese women who underwent general health screening, albuminuria, but not low eGFR, was positively associated with carotid plaque.
    Type of Medium: Online Resource
    ISSN: 1420-4096 , 1423-0143
    URL: Article
    DOI: 10.1159/000131750
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1482922-8
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Association between Changes in Obesity Parameters and Incidence of Chronic Kidney Disease in Japanese Individuals
    S. Karger AG ; 2009
    In:  Kidney and Blood Pressure Research Vol. 32, No. 2 ( 2009), p. 141-149
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 32, No. 2 ( 2009), p. 141-149
    Abstract: Obesity increases the risk for chronic kidney disease (CKD). By analyzing data on individuals who underwent general health screening in two consecutive years, we investigated whether changes in body mass index (BMI) or waist circumference (WC) were associated with the appearance or disappearance of the CKD components; micro-/macroalbuminuria (≥30 mg urinary albumin per gram creatinine) and a low estimated glomerular filtration rate (eGFR; 〈 60 ml/min/1.73 m 〈 sup 〉 2 〈 /sup 〉 ). Logistic regression analysis showed that in men with micro-/macroalbuminuria at the first visit, a BMI reduction of ≥0.42 or a WC reduction of ≥3.0 cm over the 1-year period resulted in a significantly reduced incident of micro-/macroalbuminuria at the second visit. On the other hand, a BMI gain of ≥0.33 over 1 year in men without micro-/macroalbuminuria and a low eGFR at the fist visit significantly increased the incident of micro-/macroalbuminuria and a low eGFR, respectively, at the second visit. These findings indicate that lowering the obesity indexes in men with micro-/macroalbuminuria reduced the incidence of this condition at the 1-year follow-up and that, on the contrary, an increase in BMI in men without micro-/macroalbuminuria and a low eGFR at the first examination increased the risk of these conditions during the 1-year follow-up period.
    Type of Medium: Online Resource
    ISSN: 1420-4096 , 1423-0143
    URL: Article
    DOI: 10.1159/000215739
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 1482922-8
    Location Call Number Limitation Availability
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Impacts of Changes in Obesity Parameters for the Prediction of Blood Pressure Change in Japanese Individuals
    S. Karger AG ; 2009
    In:  Kidney and Blood Pressure Research Vol. 32, No. 6 ( 2009), p. 421-427
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 32, No. 6 ( 2009), p. 421-427
    Abstract: 〈 i 〉 Aims and Methods: 〈 /i 〉 By analyzing data from 2,861 individuals who underwent general health screening 2 years running, we have investigated the impact of changes in waist circumference (WC) and body mass index (BMI) over a 1-year period on systolic blood pressure (BPs). We termed WC, BMI, and BPs at the first visit as WC1, BMI1, and BPs1, respectively, and those at the second visit as WC2, BMI2, and BPs2, respectively. The %dWC, %dBMI, and %dBPs was defined as (WC2 – WC1)/WC1 × 100, (BMI2 – BMI1)/BMI1 × 100, and (BPs2 – BPs1)/BPs1 × 100, respectively. 〈 i 〉 Results: 〈 /i 〉 In multivariate regression analysis using age, BPs1, WC1, and %dWC as independent variables, %dWC was a significant predictor for %BPs only in men. %dBMI was a significant predictor for %BPs in both genders when age, BPs1, BMI1, and %dBMI were used as independent variables. Compared with individuals with both %dWC 〈 0 and %dBMI 〈 0, age-adjusted %dBPs was significantly greater in those with both %dWC 〈 0 and %dBMI ≧0; however, it did not significantly differ in those with both %dWC ≧0 and %dBMI 〈 0. 〈 i 〉 Conclusion: 〈 /i 〉 Our data suggest that the impact of BMI change might be greater than WC change in terms of BPs change during this short period.
    Type of Medium: Online Resource
    ISSN: 1420-4096 , 1423-0143
    URL: Article
    DOI: 10.1159/000264233
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 1482922-8
    Location Call Number Limitation Availability
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    Online Resource
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