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  • S. Karger AG  (2)
  • 2005-2009  (2)
  • 1
    Online Resource
    Online Resource
    Acute Hyperglycemia and Early Hemorrhagic Transformation in Ischemic Stroke
    S. Karger AG ; 2009
    In:  Cerebrovascular Diseases Vol. 28, No. 2 ( 2009), p. 119-123
    Details
    In: Cerebrovascular Diseases, S. Karger AG, Vol. 28, No. 2 ( 2009), p. 119-123
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Hyperglycemia has been claimed to be associated with hemorrhagic transformation (HT) in patients with acute ischemic stroke treated with thrombolysis. The aim of this study was to assess whether the admission blood glucose level is related to HT in a prospective study in consecutive patients with acute ischemic stroke. 〈 i 〉 Methods: 〈 /i 〉 Consecutive patients admitted for ischemic stroke to 4 Italian hospitals were included in this prospective cohort study. 〈 i 〉 Results: 〈 /i 〉 Among 1,125 consecutive patients included in the analysis, 98 (8.7%) had HT: 62 (5.5%) had hemorrhagic infarction (HI) and 36 (3.2%) parenchymal hematoma (PH). A blood glucose level 〉 110 mg/dl was found in 42.4% of the patients, a level between 110 and 149 mg/dl in 25.2%, and a level 〉 150 mg/dl in 17.2%. At 3 months, 7 patients were lost at follow-up, 326 patients (29.2%) were disabled (modified Rankin score ≥3) and 129 died (11.5%). PH was associated with an increased risk of death or disability (OR 15.29, 95% CI 2.35–99.35). However, this was not the case for HT overall and HI. At logistic regression analysis, PH was predicted by high levels of admission blood glucose (OR 1.01, 95% CI 1.00–1.01 for 1 added mg/dl). The rate of PH was 2.1% in patients with 〈 110 mg/dl, 3.6% in patients with a level between 110 and 149 mg/dl and 6.4% in patients with a level 〉 150 mg/dl. The curve estimation regression model showed a significant linear increase in the risk of PH related to an increase in blood glucose levels (R 〈 sup 〉 2 〈 /sup 〉 = 0.007, p = 0.007). 〈 i 〉 Conclusions: 〈 /i 〉 Hyperglycemia during acute ischemic stroke predisposes to PH, which in turn determines a nonfavorable outcome at 3 months. This relationship seems to be linear.
    Type of Medium: Online Resource
    ISSN: 1015-9770 , 1421-9786
    URL: Article
    DOI: 10.1159/000223436
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 1482069-9
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  • 2
    Online Resource
    Online Resource
    Effect of On-Admission Antiplatelet Treatment on Patients with Cerebral Hemorrhage
    S. Karger AG ; 2007
    In:  Cerebrovascular Diseases Vol. 24, No. 2-3 ( 2007), p. 215-218
    Details
    In: Cerebrovascular Diseases, S. Karger AG, Vol. 24, No. 2-3 ( 2007), p. 215-218
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Antiplatelet treatment remains the first choice for primary and secondary prevention of vascular diseases; even so, expected benefits may be offset by risk of bleeding, particularly cerebral hemorrhage. The aim of this study was to assess the influence of antiplatelet treatment on clinical outcome at hospital discharge. 〈 i 〉 Materials and Methods: 〈 /i 〉 Consecutive patients with first-ever stroke due to a primary intraparenchymal hemorrhage were prospectively identified over a 4-year period (2000–2003). Data on hemorrhage location, vascular risk factors, and antiplatelet and anticoagulant treatment were collected. At discharge, outcome was measured using the modified Rankin Scale (disabling stroke ≧3). Patients treated with anticoagulant therapy were excluded from the study. 〈 i 〉 Results: 〈 /i 〉 Of 457 consecutive patients with cerebral hemorrhage, 94 (20.5%) had been taking antiplatelet agents. The treated patients (mean age for antiplatelet group 78.9 ± 9.0 years) were older than the nontreated patients (73.8 ± 9.4, p = 0.02). In-hospital mortality was 23.4 and 23.1% (p = n.s.) for patients who had been taking antiplatelet agents or no treatment. Poor outcome at discharge was found in 52.1 and 59.7% (p = n.s.), respectively. Univariate analysis showed that age and coma at admission were predictors of disability at discharge, but antiplatelet treatment was not. Additionally, age and coma were shown to be determinants of disability at discharge after multivariate analysis: OR 1.03 per year (95% CI: 1.018–1.049), p 〈 0.001 and OR 1.68 (95% CI: 1.138–2.503), p = 0.009, respectively. 〈 i 〉 Conclusions: 〈 /i 〉 Hemorrhagic stroke continues to be responsible for a high percentage of disability and death. Furthermore, it was seen here that functional outcome was independent of previous antiplatelet treatment.
    Type of Medium: Online Resource
    ISSN: 1015-9770 , 1421-9786
    URL: Article
    DOI: 10.1159/000104480
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2007
    detail.hit.zdb_id: 1482069-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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