In:
Journal of the ACM, Association for Computing Machinery (ACM), Vol. 53, No. 3 ( 2006-05), p. 361-378
Abstract:
Protein-protein interactions, which form the basis for most cellular processes, result in the formation of protein interfaces. Believing that the local shape of proteins is crucial, we take a geometric approach and present a definition of an interface surface formed by two or more proteins as a subset of their Voronoi diagram. The definition deals with the difficult and important problem of specifying interface boundaries by invoking methods used in the alpha shape representation of molecules, the discrete flow on Delaunay simplices to define pockets and reconstruct surfaces, and the assessment of the importance of topological features. We present an algorithm to construct the surface and define a hierarchy that distinguishes core and peripheral regions. This hierarchy is shown to have correlation with hot-spots in protein-protein interactions. Finally, we study the geometric and topological properties of interface surfaces and show their high degree of contortion.
Type of Medium:
Online Resource
ISSN:
0004-5411
,
1557-735X
DOI:
10.1145/1147954.1147957
Language:
English
Publisher:
Association for Computing Machinery (ACM)
Publication Date:
2006
detail.hit.zdb_id:
2006500-0
detail.hit.zdb_id:
6759-3
Permalink
