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  • 1
    Electronic Resource
    Electronic Resource
    Plant Viral Double-Stranded RNA (1984)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Phytopathology 22 (1984), S. 151-168 
    Details
    ISSN: 0066-4286
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.py.22.090184.001055
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Serum and salivary immunoglobulin A and free secretory component in ulcerative colitis (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 11 (1981), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Patients with ulcerative colitis have been investigated for evidence of defects in secretory immunity. Total serum IgA concentration, serum IgA antibody titres to Candida albicans, salivary IgA and free secretory component concentrations have been measured in thirty-six patients with ulcerative colitis and thirty-six normal controls. None of the parameters was significantly different between patients with proctitis and patients with extensive colitis or between the colitis patients and normal controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1981.tb02175.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    CFU-C inhibitors in aplastic anaemia (1984)
    Springer
    Annals of hematology 48 (1984), S. 61-74 
    Details
    ISSN: 1432-0584
    Keywords: Aplastic anaemia ; CFU-C ; Lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Peripheral blood lymphocytes from 15 patients with marrow aplasia were tested for their ability to inhibit the proliferation of normal granulopoietic precursor cells (CFU-C) in agar culture, relative to the inhibitory effect of normal lymphocytes studied in parallel. Eight of the 15 patients with marrow aplasia had lymphocytes which were significantly less inhibitory to normal CFU-C than controls whereas 3 patients had lymphocytes which were significantly more inhibitory. Two further patients who had recovered from marrow aplasia were also studied. The effect of patient's plasma and normal plasma on normal CFU-C proliferation was also studied and in 1 case a potent inhibitor of granulopoiesis was demonstrated. In 9 cases CFU-C could be cultured from patient's marrow, and parallel studies examining the effects of lymphocytes or plasma on patient's CFU-C. In none of the 9 marrow samples tested was inhibition by patient lymphocytes significantly greater than normal controls. The results highlight the heterogeneity inherent in the study of aplastic states and serve to underline the importance of controls. In only a minority of cases (20%) was lymphocyte suppression of normal granulopoiesis by lymphocytes from patients with aplastic anaemia significantly greater than normal lymphocyte suppression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320032
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    β-Lactam ring stability and antibacterial potency: A novel eigenvalue problem (1983)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 23 (1983), S. 1385-1405 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Low inoculum potency data in vitro for 16 clinical β-lactam antibiotics have been analyzed, and a physical model for interpreting the results of a number of bacterial strains has been derived. An analytic criterion for performing a unitary transformation on the potency data is developed following the identification of a physical vector present within the data which is attributable to an activation energy required for the transport of the β-lactam into a biological membrane. This vector has inverse slope relations in Gram positive and Gram negative bacteria and provides the basis for the analytic criterion for the unitary transformation. Compounds with similar potency spectra which differ only in the absolute magnitude of their effect will possess similar transport properties. It is shown that a slow rate of membrane entry for the β-lactam has overriding consequences on differences in fast rates of binding to the target enzymes and to β-lactamases, and a second primary vector is established directly from the biological data related to the ease of β-lactam ring opening. This vector offers precise evidence for testing the solvational and theoretical requirements for predicting the biological stability of novel β-lactam ring compounds.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560230423
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    Paper (German National Licenses)
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  • 5
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    Oceanographic environment of the Sodwana Bay coelacanths (Latimeria chalumnae) (2006)
    Academy of Science of South Africa
    In:  South African Journal of Science, 102 (9-10). pp. 435-443.
    Details
    Publication Date: 2020-05-26
    Description: Trimix scuba divers discovered coelacanths in Jesser Canyon at a depth of 104 m on the northern KwaZulu-Natal (KZN) coast (Sodwana Bay) in October 2000. The existence of these animals at such a shallow depth and in the swift and powerful Agulhas Current led to a suggestion that this might be an isolated group swept well away from the main population in the Comoros, where they live at depths of 200-350 m with little current. Subsequent observations from three manned submersible surveys and one remotely operated vehicle expedition together with recreational diver observations indicate that the South African population of coelacanths has at least 26 individuals, mostly occupying the depth range of 104-140 m in canyons. Seventeen CTD sections collected during four cruises in 2002 and 2003 indicate the temperature range in this habitat to be similar to that found in the Comoros Islands (that is, 15-22〈sup〉o〈/sup〉C cf. 15-19〈sup〉o〈/sup〉C in the Comoros). However, a 2.5-month-long time series of hourly data collected by a thermistor array deployed near a known coelacanth cave in Wright Canyon indicated greater variation than anticipated, with temperature changes between 16〈sup〉o〈/sup〉C and 24〈sup〉o〈/sup〉C occurring in a day. Dissolved oxygen levels in this depth zone were found to range between 3.0 ml l〈sup>-1〈/sup> and 4.8 ml l〈sup>-1〈/sup> compared to 3.5 ml l〈sup>-1〈/sup> in the Comoros. The low oxygen values along this coast are a result of the shallow oxygen minimum, which becomes shallower in the southwest Indian Ocean, particularly in the Agulhas Current, than in tropical latitudes. Current velocities measured using a ship-borne ADCP in the depth range 100-140 m at Sodwana were considerably higher than those measured in the Comoros habitat (20-60 cm s〈sup>-1〈/sup> cf. 3-4 cm s〈sup〉-1〈/sup〉) and may be an important factor explaining the coelacanths' occupation of the canyons found along the northern KZN shelf-break.
    Type: Article , PeerReviewed
    Format: text
    Format: text
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    OceanRep: Article in a Scientific Journal - peer-reviewed
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