ISSN:
1573-2592
Keywords:
Human Tμ, Tγ, Tφ lymphocytes
;
γ interferon
;
macrophage-lymphocyte interaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Human Tμ, Tγ, and Tφ lymphocyte subpopulations have the capacity to respond to phytohemagglutinin (PHA)in vitro with proliferation and the production of a pH 2 and heat-labile γ interferon. This occurs both when the subsets are isolated by direct rosetting techniques or by negative selection. Macrophages enhance the production of the γ interferon by each lymphocyte subset and do not themselves produce γ interferon in response to products of PHA-activated lymphocyte subsets. Thus our studies indicate that subpopulations of T lymphocytes known to differ with regard to morphology, surface receptors, RNA content, response to corticosteroids and X-irradiation, and other functional capabilities do not differ with regard to their capacity to produce γ interferon.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00922762
Permalink
