ISSN:
1432-0584
Keywords:
Key words Multidrug resistance
;
P-glycoprotein
;
MDR modifiers
;
Hematologic malignancies
;
Idarubicin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The multidrug resistant (MDR) phenotype has been suspected as a major cause of treatment failure in hematologic malignancies. Numerous studies have investigated the expression of the MDR1 gene product, P-glycoprotein, in leukemia, lymphoma and myeloma. Studies in myelogenous leukemia and myeloma have so far provided best evidence for a significant correlation between P-glycoprotein expression and response to chemotherapy, although large discrepancies in the proportion of positive cells limit any definite conclusion. Differences in P-glycoprotein detection techniques and methodology may account for the divergent results thus emphasizing the necessity for standardized methods of detection. Despite this, encouraging clinical results have been obtained using MDR modulators in combination with conventional chemotherapy to inhibit the activity of the P-glycoprotein pump. The paper summarizes currently available clinical data and provides guidelines for future trials aimed to reverse the MDR phenotype. The potential of idarubicin to overcome the MDR phenotype is also discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002770050147
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