GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • crystal structure  (2)
  • Hematologic malignancies  (1)
  • 2005-2009
  • 1995-1999  (3)
  • 1
    Electronic Resource
    Electronic Resource
    The MDR phenotype in hematologic malignancies: prognostic relevance and future perspectives (1996)
    Springer
    Annals of hematology 72 (1996), S. 105-117 
    Details
    ISSN: 1432-0584
    Keywords: Key words Multidrug resistance ; P-glycoprotein ; MDR modifiers ; Hematologic malignancies ; Idarubicin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The multidrug resistant (MDR) phenotype has been suspected as a major cause of treatment failure in hematologic malignancies. Numerous studies have investigated the expression of the MDR1 gene product, P-glycoprotein, in leukemia, lymphoma and myeloma. Studies in myelogenous leukemia and myeloma have so far provided best evidence for a significant correlation between P-glycoprotein expression and response to chemotherapy, although large discrepancies in the proportion of positive cells limit any definite conclusion. Differences in P-glycoprotein detection techniques and methodology may account for the divergent results thus emphasizing the necessity for standardized methods of detection. Despite this, encouraging clinical results have been obtained using MDR modulators in combination with conventional chemotherapy to inhibit the activity of the P-glycoprotein pump. The paper summarizes currently available clinical data and provides guidelines for future trials aimed to reverse the MDR phenotype. The potential of idarubicin to overcome the MDR phenotype is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050147
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Komplexbildung des tert-Butyliminovanadium(V)-trichlorids mit O-Donor-LigandenProfessor Manfred Regitz zum 60. Geburtstag gewidmet (1995)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 621 (1995), S. 1663-1671 
    Details
    ISSN: 0044-2313
    Keywords: tert-Butyliminovanadium(V) trichloride ; coordination compounds ; 1H, 13C, 51V NMR ; crystal structure ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Coordination Compounds of tert-Butyliminovanadium(V) Trichloride with O-Donor-LigandsThe reaction of tert-butyliminovanadium(V)trichloride (1) with cyclic and acyclic ethers, ethylene carbonate and thietane has been studied. The 1:1-complexes have a different stability; reversible and irreversible cleavage of ether in the coordination sphere of the vanadium atom rearranging in ω-chloroalkanolato ligands are observed. The reaction of 1 with 2-chloroethanol, 3-chloropropanol and 5-chloropentanol yields the complexes tC4H9N = V(OR)Cl2 (R = CH2CH2CH2CH2CH2Cl) and [tC4H9N = V(OR)Cl2 · ROH]; in the presence of triethylamine the disubstituted compounds tC4H9N = V(OR)2Cl are formed. The 51V NMR spectra are discussed. The crystal structure of [tC4H9N = VCl3 · DME] (12) and [tC4H9N = V(OCH2CH2Cl)Cl2 · HOCH2CH2Cl] (13) has been determined. The vanadium atoms in 13 have a distorted octahedral coordination and are linked by the oxygen atoms of the 2-chloroethanolato ligands forming a binuclear complex. In solution molecular weight measurement and 51V NMR data indicate the equilibrium between a mononuclear complex 13 and its isomer [tC4H9N = V(OCH2CH2Cl)2Cl · HCl].
    Notes: Die Reaktion des tert-Butyliminovanadium(V)-trichlorids (1) mit cyclischen und acyclischen Ethern, Ethylencarbonat und Thietan wurde untersucht. Die 1:1-Komplexe zeigen eine unterschiedliche Stabilität; reversible und irreversible Etherspaltungen in der Koordinationssphäre des Vanadiumatoms unter Umlagerung in ω-Chloralkanolato-Liganden werden beobachtet. Die Reaktion von 1 mit 2-Chlorethanol, 3-Chlorpropanol und 5-Chlorpentanol liefert die Komplexe tC4H9N = V(OR)Cl2 (R = CH2CH2CH2CH2CH2Cl) und [tC4H9N = V(OR)Cl2 ω HOR]; in Gegenwart von Triethylamin als Hilfsbase werden die disubstituierten Verbindungen tC4H9N = V(OR)2Cl gebildet. Die 51V-NMR-Spektren werden diskutiert. Die Kristallstruktur der Komplexe [tC4H9N = VCl3 · DME] (12) und [tC4H9N = V(OCH2CH2Cl)Cl2 · HOCH2CH2Cl] (13) wurde bestimmt. In 13 sind die verzerrt oktaedrisch koordinierten Vanadiumatome über die O-Atome der 2-Chlorethanolato-Liganden zu einem zweikernigen Komplex verknüpft, während in Lösung ein einkerniger Komplex im Gleichgewicht mit dem Isomeren [tC4H9N = V(OCH2CH2Cl)2Cl · HCl] vorliegt.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19956211009
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Phosphan-, Phosphit- und Phosphido-Komplexe des Vanadiums(V) (1997)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 623 (1997), S. 1220-1228 
    Details
    ISSN: 0044-2313
    Keywords: Phosphane ; phosphite ; phosphido complexes of vanadium(V) ; syntheses ; 1H, 51V, 31P NMR ; crystal structure ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Phosphane, Phosphite, Phosphido, Complexes of Vanadium(V)Complex formation of tert-butylimidovanadium(V)trichloride (1) with phosphanes und phosphites has been studied. Syntheses of phosphidovanadium(V) compounds tC4H9N=VCp(NHtC4H9)[P(SiMe3)2] and tC4H9N=VCp(NiProp2)(PR2) (R=SiMe3, Ph) are described starting from the corresponding chlorovanadium(V) complexes. The reaction of 1 with silver hexafluorophosphate yields a bis(fluoro)phosphidovanadium(IV complex [(μ-PF2)2V2Cl2)(NtC4H9)2]; as primary intermediate product of the unknown redox reaction a cationic vanadium(V) complex [tC4H9N=VCl2 · PPh3]+PF6- has been isolated. 1 reacts with an excess of diisopropylamine forming tC4H9N=V(NiProp2)Cl2 (16); in addition the following diisopropylamido-tert-butylimidovanadium(V) compounds tC4H9N=VCp(NiProp2)Cl (3) and tC4H9N=V(NiProp2)X2 (X=CH2CMe3, OtC4H9, CH3COO) has been prepared. All compounds obtained are characterized by 1H, 51V, 31P NMR spectroscopy. The X-ray diffraction analysis of 16 and 3 indicate a planar coordination sphere of the amido nitrogen atom.
    Notes: Die Komplexbildung des tert-Butylimidovanadium(V)-trichlorids (1) mit Phosphanen und Phosphiten wurde untersucht. Die Darstellung der Phosphidovanadium(V)-Verbindungen tC4H9N=VCp(NHtC4H9)[P(SiMe3)2] und tC4H9N=VCp(NiProp2)(PR2) (R=SiMe3, Ph) wird beschrieben; als Ausgangsverbindungen werden entsprechende Chorovanadium(V)-Komplexe eingesetzt. Die Reaktion von 1 mit Silberhexafluorophosphat führt zu einem Difluorphosphidovanadium(IV)-Komplex [(μ-PF2)2V2Cl2(NtC4H9)2]; als erste Zwischenstufe der unbekannten Redoxreaktion wurde ein kationischer Vanadium(V)-Komplex [tC4H9N=VCl2 · PPh3]+PF6- isoliert. 1 reagiert mit überschüssigem Diisopropylamin unter Bildung von tC4H9N=V(NiProp2)Cl2 (16); weitere Umsetzungen lieferten die Diisopropylamido-tert-butylimido-vanadium(V)-Verbindungen tC4H9N=VCp(NiProp2)Cl (3) und tC4H9N=V(NiProp2)X2 (X=CH2CMe3, OtC4H9, CH3COO). Alle dargestellten Verbindungen werden 1H-, 51V- und 31P-NMR-spektroskopisch charakterisiert. Die Röntgenstrukturanalyse von 16 und 3 zeigt eine planare Koordinationssphäre des Amido-Stickstoffatoms.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19976230807
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...