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  • 2005-2009  (1)
  • 2000-2004  (4)
  • 1
    Online Resource
    Online Resource
    San Diego :Elsevier Science & Technology,
    Keywords: Biology -- Research. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (510 pages)
    Edition: 1st ed.
    ISBN: 9780080552897
    Language: English
    Note: FRONT COVER -- RESEARCH METHODOLOGY IN THE MEDICAL AND BIOLOGICAL SCIENCES -- COPYRIGHT PAGE -- CONTENTS -- PREFACE -- ACKNOWLEDGEMENTS -- CONTRIBUTORS -- LIST OF ABBREVIATIONS AND SYMBOLS -- CHAPTER 1 PHILOSOPHY OF SCIENCE -- 1.1 Philosophy of the natural sciences -- 1.2 Philosophy of the social sciences -- References -- Further reading -- CHAPTER 2 ETHICS AND SCIENTIFIC CONDUCT -- 2.1 A brief introduction to ethics -- 2.2 Scientific conduct and misconduct -- 2.3 Misconduct and why it occurs -- 2.4 Fabrication and other forms of misconduct affecting the truth claims of scientific findings -- 2.5 Authorship issues -- 2.6 Salami, imalas and duplicate publication -- 2.7 The investigation and punishment of scientific misconduct -- References -- Further reading -- Appendix 1 -- CHAPTER 3 ETHICS IN HUMAN AND ANIMAL STUDIES -- 3.1 Introduction -- 3.2 Basic principles of human research ethics -- 3.3 International regulation -- 3.4 The ethics of animal research -- References -- Further reading -- Appendix 1 World Medical Association Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects -- Appendix 2 Oviedo Convention (Council of Europe, European Treaty Series 164) -- Appendix 3 Oviedo Convention - Additional Protocol Concerning Biomedical Research, Chapter I-IX (Council of Europe, European Treaty Series 195) -- CHAPTER 4 RESEARCH METHODOLOGY: STRATEGIES, PLANNING AND ANALYSIS -- 4.1 Introduction -- 4.2 Your scientific problem -- 4.3 More on scientific problems -- 4.4 Literature, methods and techniques -- 4.5 Research conditions -- 4.6 Data types -- 4.7 Techniques -- 4.8 Repeatability, reproducibility and reliability -- 4.9 Validity, effect measure and choice of statistical test -- 4.10 Experimental protocol -- 4.11 Experimental routine -- References -- Further reading. , CHAPTER 5 LITERATURE SEARCH AND PERSONAL REFERENCE DATABASES -- 5.1 Information literacy -- 5.2 Systematic literature search -- 5.3 How to formulate a query: PICO -- 5.4 Search technique -- 5.5 Methodology filters -- 5.6 Quality: critical appraisal -- 5.7 Impact factor -- 5.8 Principal bibliographic databases -- 5.9 Staying up to date -- 5.10 Medical and scientific Internet search engines -- 5.11 Personal reference databases -- References -- Further reading -- CHAPTER 6 METHODS IN MOLECULAR BIOLOGY -- 6.1 Introduction -- 6.2 Recombinant DNA technology -- 6.3 DNA and RNA: isolation, identification, synthesis and analysis -- 6.4 Practical applications of DNA/RNA technology -- 6.5 Protein analyses -- 6.6 Bioinformatics -- References -- CHAPTER 7 STRATEGIES AND METHODS OF BASIC MEDICAL RESEARCH -- 7.1 Introduction -- 7.2 Long-term goals and specific aims -- 7.3 Background and significance -- 7.4 Experimental strategies and methods -- 7.5 Pilot studies -- 7.6 Rules for basic medical research projects -- References -- Further reading -- CHAPTER 8 CLINICAL RESEARCH -- 8.1 Controlled clinical trials -- 8.2 Publication bias -- 8.3 Estimating sample size -- 8.4 'Non-inferiority' studies -- 8.5 Generalization -- References -- Guidelines -- CHAPTER 9 EPIDEMIOLOGY: CONCEPTS AND METHODS -- 9.1 Introduction -- 9.2 Definitions -- 9.3 The role of epidemiology -- 9.4 Population and sample -- 9.5 Measures of disease occurrence, association, risk and implications -- 9.6 Vital statistics -- 9.7 Study designs of epidemiological studies -- 9.8 Effect measures in epidemiological studies -- 9.9 Experimental studies and randomized control trials -- 9.10 Measurement error and sources of error -- 9.11 Tests and validity -- 9.12 Causes of disease -- 9.13 Association versus causality -- References -- Further reading -- CHAPTER 10 QUALITATIVE RESEARCH. , 10.1 Qualitative versus quantitative research -- 10.2 Using qualitative research -- 10.3 What qualitative research cannot be used for -- 10.4 Samples in qualitative studies -- 10.5 Reliability and validity -- 10.6 Ethical challenges in qualitative research -- 10.7 Qualitative data collection -- 10.8 Triangulation -- 10.9 Analyses of qualitative data -- 10.10 Releasing qualitative data -- References -- Further reading -- CHAPTER 11 STATISTICAL ISSUES -- 11.1 Introduction -- 11.2 Effect measure, hypothesis testing and confidence interval -- 11.3 Bernoulli trial -- 11.4 Comparing two proportions -- 11.5 Measures of association in 2 × 2 tables -- 11.6 Normal distribution -- 11.7 Comparison of means -- 11.8 Non-parametric methods -- 11.9 Regression analysis -- References -- Further reading -- CHAPTER 12 EVIDENCE-BASED PRACTICE AND CRITICAL APPRAISAL OF SYSTEMATIC REVIEWS -- 12.1 Introduction -- 12.2 Systematic reviews -- 12.3 Critical appraisal of a systematic review: one example -- 12.4 Summary -- References -- Further reading -- CHAPTER 13 SCIENTIFIC COMMUNICATION -- 13.1 Introduction -- 13.2 The scientific paper -- 13.3 Posters -- References -- Further reading -- CHAPTER 14 SUCCESSFUL LECTURING -- 14.1 Introduction -- 14.2 Preparing the lecture -- 14.3 Lecture content and form -- 14.4 Manuscript -- 14.5 Delivering a lecture -- Further reading -- CHAPTER 15 GUIDE TO GRANT APPLICATIONS -- 15.1 Introduction -- 15.2 Getting started -- 15.3 The postdoctoral fellow and junior scientist -- 15.4 What goes into a successful grant application? -- 15.5 The investigator-initiated research grant -- 15.6 Multiproject grants -- 15.7 International research collaborations -- 15.8 The European Union's seventh Framework Programme -- 15.9 Summary and perspective -- References -- INDEX -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q. , R -- S -- T -- U -- V -- W -- X -- Y -- Z.
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Cell and Developmental Biology 16 (2000), S. 191-220 
    ISSN: 1081-0706
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Early development of the vertebrate skeleton depends on genes that pattern the distribution and proliferation of cells from cranial neural crest, sclerotomes, and lateral plate mesoderm into mesenchymal condensations at sites of future skeletal elements. Within these condensations, cells differentiate to chondrocytes or osteoblasts and form cartilages and bones under the control of various transcription factors. In most of the skeleton, organogenesis results in cartilage models of future bones; in these models cartilage is replaced by bone by the process of endochondral ossification. Lastly, through a controlled process of bone growth and remodeling the final skeleton is shaped and molded. Significant and exciting insights into all aspects of vertebrate skeletal development have been obtained through molecular and genetic studies of animal models and humans with inherited disorders of skeletal morphogenesis, organogenesis, and growth.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Cherubism (MIM 118400) is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws followed by development of fibrous tissue masses, which causes a characteristic facial swelling. Here we describe seven mutations in the SH3-binding protein ...
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We describe a technique for the treatment of malignant brain tumors based on local delivery of the anti-angiogenic protein endostatin from genetically engineered cells encapsulated in ultrapure sodium alginate. Alginate consists of L-guluronic and D-mannuronic acid, which in the presence of ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 423 (2003), S. 343-348 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We walk, run, work and play, paying little attention to our bones, their joints and their muscle connections, because the system works. Evolution has refined robust genetic mechanisms for skeletal development and growth that are able to direct the formation of a complex, yet wonderfully adaptable ...
    Type of Medium: Electronic Resource
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