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  • 2005-2009  (3)
  • 2000-2004  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genomics and Human Genetics 3 (2002), S. 311-340 
    ISSN: 1527-8204
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Genetic screens in Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio clarified the logic of metazoan development by revealing critical unitary steps and pathways to embryogenesis. Can genetic screens similarly organize medicine? We here examine human diseases that resemble mutations in Danio rerio, the zebrafish, the one vertebrate species for which large-scale genetic screens have been performed and extensively analyzed. Zebrafish mutations faithfully phenocopy many human disorders. Each mutation, once cloned, provides candidate genes and pathways for evaluation in the human. The collection of mutations in their entirety potentially provides a medical taxonomy, one based in developmental biology and genetics.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] We identified a human mutation that causes dilated cardiomyopathy and heart failure preceded by sensorineural hearing loss (SNHL). Unlike previously described mutations causing dilated cardiomyopathy that affect structural proteins, this mutation deletes 4,846 bp of the human transcriptional ...
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2021-09-03
    Description: Collaboratory for the Study of Earthquake Predictability
    Description: Istituto Nazionale di Geofisica e Vulcanologia (INGV), Rome, Italy Institute of Statistical Mathematics (ISM), Tokyo, Japan Swiss Seismological Service, Institute of Geophysics (ETH), Zürich, Switzerland
    Description: Unpublished
    Description: Erice, Italy
    Description: open
    Keywords: Eartquake Predictability ; 04. Solid Earth::04.06. Seismology::04.06.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Oral presentation
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  • 4
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    In:  Earth and Planetary Science Letters
    Publication Date: 2020-02-12
    Description: The coherence of azimuthal seismic anisotropy, as inferred from shear-wave splitting measurements, decreases with the relative distance between stations. Stochastic models of a two-dimensional vector field defined by a von Karma'n [T. von Karma'n, Progress in the statistical theory of turbulence, J. Mar. Res., 7 (1948) 252–264.] autocorrelation function with horizontal correlation length L provide a useful means to evaluate this heterogeneity and coherence lengths. We use the compilation of SKS splitting measurements by Fouch [M. Fouch, Upper mantle anisotropy database, accessed in 06/2006, http://geophysics.asu.edu/anisotropy/upper/] and supplement it with additional studies, including automated measurements by Evans et al. [Evans, M.S., Kendall, J.-M., Willemann, R.J., 2006. Automated SKS splitting and upper-mantle anisotropy beneath Canadian seismic stations, Geophys. J. Int. 165, 931–942, Evans, M.S., Kendall, J.-M., Willemann, R.J. Automated splitting project database, Online at http://www.isc.ac.uk/SKS/, accessed 02/2006]. The correlation lengths of this dataset depend on the geologic setting in the continental regions: in young Phanerozoic orogens and magmatic zones L ∼ 600 km, smaller than the smooth L ∼ 1600 km patterns in tectonically more stable regions such as Phanerozoic platforms. Our interpretation is that the relatively large coherence underneath older crust reflects large-scale tectonic processes (e.g. continent–continent collisions) that are frozen into the tectosphere. In younger continental regions, smaller scale flow (e.g. slab anomaly induced) may predominantly affect anisotropy. In this view, remnant anisotropy is dominant in the old continents and deformation-induced anisotropy caused by recent asthenospheric flow is dominant in active continental regions and underneath oceanic plates. Auxiliary analysis of surface-wave anisotropy and combined mantle flow and anisotropic texture modeling is consistent with this suggestion. In continental regions, the further exploration of a stochastic description of seismic anisotropy may form a useful counterpart to deterministic forward modeling, particularly if we wish to understand the origin of discrepancies in heterogeneity estimates based on different seismological data sets.
    Language: English
    Type: info:eu-repo/semantics/article
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