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  • 2010-2014  (55)
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  • 1
    Online Resource
    Online Resource
    Blue Ridge Summit :M. Evans & Company, Incorporated,
    Keywords: Schmidt, Karl Patterson, 1890-1957 -- Juvenile literature. ; Schmidt, Karl Patterson, 1890-1957. ; Electronic books.
    Description / Table of Contents: This biography of noted scientist Karl Patterson Schmidt is especially designed for young naturalists, as his life story is accompanied by fun and accessible projects for the budding herpetologist. 20 b&w illustrations.
    Type of Medium: Online Resource
    Pages: 1 online resource (71 pages)
    Edition: 1st ed.
    ISBN: 9781590773611
    DDC: 092
    Language: English
    Note: Intro -- 1. Karl's Formative Years -- 2. Six Years on a Wilderness Farm -- 3. A Decision in the Swamps -- 4. A Coming of Age in Herpetology -- 5. A Developing Career -- 6. The Great Voyage -- 7. Karl P. Schmidt, Naturalist-Author -- Nature Projects You Can Do -- Bibliography.
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  • 2
    Online Resource
    Online Resource
    Saint Louis :Elsevier Science & Technology,
    Keywords: Active nitrogen. ; Electronic books.
    Description / Table of Contents: Physical Chemistry, A Series of Monographs: Active Nitrogen presents the methods by which active nitrogen may be produced. This book is composed of five chapters that evaluate the energy content, molecular spectrum, and the emission of active nitrogen. Some of the topics covered in the book are the summary of light-emitting systems of active nitrogen; analysis of Long-Lived Lewis-Rayleigh Afterglow theory and Ionic theory of Mitra; reactions followed by induced light emission; and characteristics of homogeneous recombination. Other chapters deal with the analysis of metastable molecule theories and the mechanisms for reactions of active nitrogen involving direct N(4S) attack. The discussion then shifts to the rate constants for reactions induced by direct N(4S) attack. The evaluation of the Short-Lived Energetic Afterglow theory is presented. The final chapter is devoted to the examination of emission from molecular species with electronic energy levels below 9.76 eV. The book can provide useful information to physicists, students, and researchers.
    Type of Medium: Online Resource
    Pages: 1 online resource (615 pages)
    Edition: 1st ed.
    ISBN: 9781483194868
    Series Statement: Physical Chemistry : A Series of Monographs
    DDC: 546/.711/1
    Language: English
    Note: Front Cover -- Active Nitrogen -- Copyright Page -- Table of Contents -- Dedication -- PREFACE -- CHAPTER 1. INTRODUCTION -- I. A Brief Description of Active Nitrogen and Its Discovery -- II. The Energy Content of Active Nitrogen and the Bond Dissociation Energy of N2 -- III. Methods by Which Active Nitrogen May Be Produced -- CHAPTER 2. LIGHT EMISSION FROM ACTIVE NITROGEN SYSTEMS -- I. The Molecular Spectrum of Nitrogen -- II. Emission from Molecular Species with Electronic Energy Levels below 9.76 eV -- III. Emission from Molecular Species with Electronic Energy Levels above 9.76 eV -- IV. Emission from Atomic Nitrogen -- V. Emission from Condensed Active Nitrogen or Activated Solid Nitrogen -- VI. Summary of Light-Emitting Systems of Active Nitrogen -- CHAPTER 3. AFTERGLOW SPECIES, THEIR LIFETIMES AND CONCENTRATIONS -- I. Atomic Species -- II. Molecular Species with Energy Content Less than 9.76 eV -- III. Molecular Species with Energy Content Greater than 9.76 eV -- IV. Other Species -- V. Summary -- CHAPTER 4. THEORIES OF ACTIVE NITROGEN -- I. The Long-Lived Lewis-Rayleigh Afterglow -- II. The Short-Lived, Energetic Afterglows -- CHAPTER 5. CHEMICAL REACTIONS OF ACTIVE NITROGEN -- I. Recombination of N(4S) Atoms -- II. Survey of Reactions Investigated -- III. Mechanisms for Reactions of Active Nitrogen That Appear to Involve Direct N(4S) Attack -- IV. Rate Constants for Reactions Presumably Induced by Direct N(4S) Attack -- V. Reactions Possibly Induced by Excited Nitrogen Molecule Attack -- BIBLIOGRAPHY -- AUTHOR INDEX -- SUBJECT INDEX.
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  • 3
    Publication Date: 2013-08-17
    Description: New treatment strategies are urgently needed to overcome early mortality in acute bacterial infections. Previous studies have shown that administration of a novel immunoactivating peptide (P4) alongside passive immunotherapy prevents the onset of septicemia and rescues mice from lethal invasive disease models of pneumococcal pneumonia and sepsis. In this study, using two diverse populations of adult volunteers, we determined whether P4 treatment of human alveolar macrophages would upregulate phagocytic killing of Streptococcus pneumoniae ex vivo . We also measured macrophage intracellular oxidation, cytokine secretion, and surface marker expression following stimulation. Peptide treatment showed enhanced bacterial killing in the absence of nonspecific inflammation, consistent with therapeutic potential. This is the first demonstration of P4 efficacy on ex vivo -derived human lung cells.
    Print ISSN: 0066-4804
    Electronic ISSN: 1098-6596
    Topics: Biology , Medicine
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  • 4
    Publication Date: 2024-04-17
    Description: Ice thickness data over much of East Antarctica are sparse and irregularly distributed. This poses difficulties for reconstructing the homogeneous coverage needed to properly assess underlying sub-glacial morphology and fundamental geometric constraints on sea level rise. Here we introduce a new physically-based ice thickness interpolation scheme and apply this to existing ice thickness data in the Aurora Subglacial Basin region. The skill and robustness of the new reconstruction is demonstrated by comparison with new data from the ICECAP project. The interpolated morphology shows an extensive marine-based ice sheet, with considerably more area below sea-level than shown by prior studies. It also shows deep features connecting the coastal grounding zone with the deepest regions in the interior. This has implications for ice sheet response to a warming ocean and underscores the importance of obtaining additional high resolution data in these marginal zones for modelling ice sheet evolution.
    Description: Published
    Description: 551-560
    Description: 3.8. Geofisica per l'ambiente
    Description: JCR Journal
    Description: open
    Keywords: Ice ; Cryosphere ; RES systems ; Ice thickness ; 02. Cryosphere::02.02. Glaciers::02.02.04. Ice
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 5
    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
    Type: info:eu-repo/semantics/conferenceObject
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  • 6
    Publication Date: 2012-08-28
    Description: Age-related macular degeneration (AMD) is a leading cause of visual loss in Western populations. Susceptibility is influenced by age, environmental and genetic factors. Known genetic risk loci do not account for all the heritability. We therefore carried out a genome-wide association study of AMD in the UK population with 893 cases of advanced AMD and 2199 controls. This showed an association with the well-established AMD risk loci ARMS2 (age-related maculopathy susceptibility 2)– HTRA1 (HtrA serine peptidase 1) ( P = 2.7 x 10 –72 ), CFH (complement factor H) ( P = 2.3 x 10 –47 ), C2 (complement component 2)– CFB (complement factor B) ( P = 5.2 x 10 –9 ), C3 (complement component 3) ( P = 2.2 x 10 –3 ) and CFI ( P = 3.6 x 10 –3 ) and with more recently reported risk loci at VEGFA ( P = 1.2 x 10 –3 ) and LIPC (hepatic lipase) ( P = 0.04). Using a replication sample of 1411 advanced AMD cases and 1431 examined controls, we confirmed a novel association between AMD and single-nucleotide polymorphisms on chromosome 6p21.3 at TNXB (tenascin XB)– FKBPL (FK506 binding protein like) [rs12153855/rs9391734; discovery P = 4.3 x 10 –7 , replication P = 3.0 x 10 –4 , combined P = 1.3 x 10 –9 , odds ratio (OR) = 1.4, 95% confidence interval (CI) = 1.3–1.6] and the neighbouring gene NOTCH4 (Notch 4) (rs2071277; discovery P = 3.2 x 10 –8 , replication P = 3.8 x 10 –5 , combined P = 2.0 x 10 –11 , OR = 1.3, 95% CI = 1.2–1.4). These associations remained significant in conditional analyses which included the adjacent C2 – CFB locus. TNXB , FKBPL and NOTCH4 are all plausible AMD susceptibility genes, but further research will be needed to identify the causal variants and determine whether any of these genes are involved in the pathogenesis of AMD.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 7
    Publication Date: 2012-08-15
    Description: CO2 capture and storage (CCS) has the potential to develop into an important tool to address climate change. Given society’s present reliance on fossil fuels, widespread adoption of CCS appears indispensable for meeting stringent climate targets. We argue that for conventional CCS to become a successful climate mitigation technology—which by...
    Keywords: Sustainability Science
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 8
    Publication Date: 2012-10-06
    Description: The prevalence of Vibrio vulnificus on the external surfaces of fish from the northern Gulf of Mexico was determined in this study. A collection of 242 fish comprising 28 species was analyzed during the course of 12 sampling trips over a 16-month period. The prevalence of V. vulnificus was 37% but increased up to 69% in summer. A positive correlation was found between the percentages of V. vulnificus -positive fish and water temperatures, while salinity and V. vulnificus -positive fish prevalence were inversely correlated. A general lineal model (percent V. vulnificus -positive fish = 0.5930 – 0.02818 x salinity + 0.01406 x water temperature) was applied to best fit the data. Analysis of the population structure was carried out using 244 isolates recovered from fish. Ascription to 16S rRNA gene types indicated that 157 isolates were type A (62%), 72 (29%) were type B, and 22 (9%) were type AB. The percentage of type B isolates, considered to have greater virulence potential, was higher than that previously reported in oyster samples from the northern Gulf of Mexico. Amplified fragment length polymorphism (AFLP) was used to resolve the genetic diversity within the species. One hundred twenty-one unique AFLP profiles were found among all analyzed isolates, resulting in a calculated Simpson's index of diversity of 0.991. AFLP profiles were not grouped on the basis of collection date, fish species, temperature, or salinity, but isolates were clustered into two main groups that correlated precisely with 16S rRNA gene type. The population of V. vulnificus associated with fishes from the northern Gulf of Mexico is heterogeneous and includes strains of great virulence potential.
    Print ISSN: 0099-2240
    Electronic ISSN: 1098-5336
    Topics: Biology
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  • 9
    Publication Date: 2012-05-23
    Description: The W chromosome is predicted to be subject to strong female-specific selection stemming from its female-limited inheritance and therefore should play an important role in female fitness traits. However, the overall importance of directional selection in shaping the W chromosome is unknown because of the powerful degradative forces that act to decay the nonrecombining sections of the genome. Here we greatly expand the number of known W-linked genes and assess the expression of the W chromosome after 〉100 generations of different female-specific selection regimens in different breeds of chicken and in the wild ancestor, the Red Jungle Fowl. Our results indicate that female-specific selection has a significant effect on W chromosome gene-expression patterns, with a strong convergent pattern of up-regulation associated with increased female-specific selection. Many of the transcriptional changes in the female-selected breeds are the product of positive selection, suggesting that selection is an important force in shaping the evolution of gene expression on the W chromosome, a finding consistent with both the importance of the W chromosome in female fertility and the haploid nature of the W. Taken together, these data provide evidence for the importance of the sex-limited chromosome in a female heterogametic species and show that sex-specific selection can act to preserve sex-limited chromosomes from degrading forces.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 10
    Publication Date: 2012-04-25
    Description: To use lymphocytes as surrogate cells to investigate their in vitro sensitivities to ultraviolet (UV) treatment in different cancers and precancerous states by comparison with lymphocytes from healthy control individuals was the main aim of this research. UV light induces precise cellular and genomic mutations. In this study, the effect of ultraviolet A (UVA) (320–400 nm) was used as a generic mutagen to evaluate in vitro different sensitivities from lymphocytes of patients with suspected melanoma (SM), malignant melanoma (MM), polyposis coli (PC) and colorectal cancer (CRC). DNA damage was evaluated by two different methods: the micronucleus (MN) assay and the Comet assay. The baseline frequency of MNs was significantly increased in lymphocytes from all patients (SM, MM, PC and CRC) when compared to healthy individuals. After UV irradiation, MN frequencies were significantly increased in lymphocytes of all groups, both patients and healthy individuals. However, the MN frequency in all patient groups was significantly higher than in the healthy individual group. Similar results for the induction of genomic DNA damage were obtained for the Comet assay. Also for the Comet assay, UVA-induced DNA damage for all four patient groups was significantly increased when compared to healthy individuals (SM, MM, PC and CRC groups: P 〈 0.001). Conclusively, peripheral lymphocytes from patients with cancers MM and CRC or precancerous states SM and PC are more sensitive to a generic mutagen such as UVA than lymphocytes from healthy individuals. This feature may be used as an essential biomarker to screen and diagnose precancerous states and cancers in early stages.
    Print ISSN: 0267-8357
    Electronic ISSN: 1464-3804
    Topics: Biology , Medicine
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