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  • 2010-2014  (6)
  • 1
    Keywords: Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (583 pages)
    Edition: 1st ed.
    ISBN: 9781583945957
    DDC: 615/.329
    Language: English
    Note: Intro -- Title Page -- Copyright -- Dedication -- Acknowledgments -- Author and Publisher's Disclaimer -- Contents -- Foreword by Solomon P. Wasser -- Author's Preface -- Introduction -- Part One: Mushrooms -- Part Two: The Lichens -- Appendix A: The Fung-Alchemical Process -- Appendix B: Medicinal Properties -- Appendix C: Anticancer Activity -- Appendix D: Antiviral Activity -- Appendix E: Antimicrobial Activity -- References -- Resources -- Photography Credits -- About the Author.
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  • 2
    Publication Date: 2013-06-29
    Description: Journal of Proteome Research DOI: 10.1021/pr400321x
    Print ISSN: 1535-3893
    Electronic ISSN: 1535-3907
    Topics: Chemistry and Pharmacology
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  • 3
    Publication Date: 2013-07-04
    Description: Analytical Chemistry DOI: 10.1021/ac400982w
    Print ISSN: 0003-2700
    Electronic ISSN: 1520-6882
    Topics: Chemistry and Pharmacology
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  • 4
    Publication Date: 2012-01-12
    Description: The bacterial luciferase gene cassette (lux) is unique among bioluminescent bioreporter systems due to its ability to synthesize and/or scavenge all of the substrate compounds required for its production of light. As a result, the lux system has the unique ability to autonomously produce a luminescent signal, either continuously or in response to the presence of a specific trigger, across a wide array of organismal hosts. While originally employed extensively as a bacterial bioreporter system for the detection of specific chemical signals in environmental samples, the use of lux as a bioreporter technology has continuously expanded over the last 30 years to include expression in eukaryotic cells such as Saccharomyces cerevisiae and even human cell lines as well. Under these conditions, the lux system has been developed for use as a biomedical detection tool for toxicity screening and visualization of tumors in small animal models. As the technologies for lux signal detection continue to improve, it is poised to become one of the first fully implantable detection systems for intra-organismal optical detection through direct marriage to an implantable photon-detecting digital chip. This review presents the basic biochemical background that allows the lux system to continuously autobioluminesce and highlights the important milestones in the use of lux-based bioreporters as they have evolved from chemical detection platforms in prokaryotic bacteria to rodent-based tumorigenesis study targets. In addition, the future of lux imaging using integrated circuit microluminometry to image directly within a living host in real-time will be introduced and its role in the development of dose/response therapeutic systems will be highlighted.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Published by MDPI Publishing
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  • 5
    Publication Date: 2012-07-27
    Description: Background: Telehealth (TH) and telecare (TC) interventions are increasingly valued for supporting selfcarein ageing populations; however, evaluation studies often report high rates of nonparticipationthat are not well understood. This paper reports from a qualitative study nestedwithin a large randomised controlled trial in the UK: the Whole System Demonstrator (WSD)project. It explores barriers to participation and adoption of TH and TC from the perspectiveof people who declined to participate or withdrew from the trial. Methods: Qualitative semi-structured interviews were conducted with 22 people who declined toparticipate in the trial following explanations of the intervention (n = 19), or who withdrewfrom the intervention arm (n = 3). Participants were recruited from the four trial groups (withdiabetes, chronic obstructive pulmonary disease, heart failure, or social care needs); and allcame from the three trial areas (Cornwall, Kent, east London). Observations of home visitswhere the trial and interventions were first explained were also conducted by shadowing 8members of health and social care staff visiting 23 people at home. Field notes were made ofobservational visits and explored alongside interview transcripts to elicit key themes. Results: Barriers to adoption of TH and TC associated with non-participation and withdrawal from thetrial were identified within the following themes: requirements for technical competence andoperation of equipment; threats to identity, independence and self-care; expectations andexperiences of disruption to services. Respondents held concerns that special skills wereneeded to operate equipment but these were often based on misunderstandings. Respondents'views were often explained in terms of potential threats to identity associated with positiveageing and self-reliance, and views that interventions could undermine self-care and coping.Finally, participants were reluctant to risk potentially disruptive changes to existing servicesthat were often highly valued. Conclusions: These findings regarding perceptions of potential disruption of interventions to identity andservices go beyond more common expectations that concerns about privacy and dislike oftechnology deter uptake. These insights have implications for health and social care staffindicating that more detailed information and time for discussion could be valuable especiallyon introduction. It seems especially important for potential recipients to have the opportunityto discuss their expectations and such views might usefully feed back into design andImplementation
    Electronic ISSN: 1472-6963
    Topics: Medicine
    Published by BioMed Central
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  • 6
    Publication Date: 2014-10-29
    Description: Background: Available birth settings have diversified in Canada since the integration of regulated midwifery. Midwives are required to offer eligible women choice of birth place; and 25-30% of midwifery clients plan home births. Canadian provincial health ministries have instituted reimbursement schema and regulatory guidelines to ensure access to midwives in all settings. Evidence from well-designed Canadian cohort studies demonstrate the safety and efficacy of midwife-attended home birth. However, national rates of planned home birth remain low, and many maternity providers do not support choice of birth place. Methods: In this national, mixed-methods study, our team administered a cross-sectional survey, and developed a 17 item Provider Attitudes to Planned Home Birth Scale (PAPHB-m) to assess attitudes towards home birth among maternity providers. We entered care provider type into a linear regression model, with the PAPHB-m score as the outcome variable. Using Students' t tests and ANOVA for categorical variables and correlational analysis (Pearson's r) for continuous variables, we conducted provider-specific bivariate analyses of all socio-demographic, education, and practice variables (n=90) that were in both the midwife and physician surveys. Results: Median favourability scores on the PAPHB-m scale were very low among obstetricians (33.0), moderately low for family physicians (38.0) and very high for midwives (80.0), and 84% of the variance in attitudes could be accounted for by care provider type. Amount of exposure to planned home birth during midwifery or medical education and practice was significantly associated with favourability scores. Concerns about perinatal loss and lawsuits, discomfort with inter-professional consultations, and preference for the familiarity of the hospital correlated with less favourable attitudes to home birth. Among all providers, favourability scores were linked to beliefs about the evidence on safety of home birth, and confidence in their own ability to manage obstetric emergencies at a home birth. Conclusions: Increasing the knowledge base among all maternity providers about planned home birth may increase favourability. Key learning competencies include criteria for birth site selection, management of obstetric emergencies at planned home births, critical appraisal of literature on safety of home birth, and inter-professional communication and collaboration when women are transferred from home to hospital.
    Electronic ISSN: 1471-2393
    Topics: Medicine
    Published by BioMed Central
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