Description: Purpose A prototype wireless guidance device using single sideband amplitude modulation (SSB) is presented for a 1.5T magnetic resonance imaging system. Methods The device contained three fiducial markers each mounted to an independent receiver coil equipped with wireless SSB technology. Acquiring orthogonal projections of these markers determined the position and orientation of the device, which was used to define the scan plane for a subsequent image acquisition. Device localization and scan plane update required approximately 30 ms, so it could be interleaved with high temporal resolution imaging. Since the wireless device is used for localization and does not require full imaging capability, the design of the SSB wireless system was simplified by allowing an asynchronous clock between the transmitter and receiver. Results When coupled to a high readout bandwidth, the error caused by the lack of a shared frequency reference was quantified to be less than one pixel (0.78 mm) in the projection acquisitions. Image guidance with the prototype was demonstrated with a phantom where a needle was successfully guided to a target and contrast was delivered. Conclusion The feasibility of active tracking with a wireless detector array is demonstrated. Wireless arrays could be incorporated into devices to assist in image-guided procedures. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc.

Description: Author(s): Wen-Che Tsai, Yen-Ting Chen, Chia-Hsien Lin, Wei-Ting Hsu, Yung-Sheng Hsu, Li-Chyong Chen, Kuei-Hsien Chen, and Wen-Hao Chang The optical properties of single InGaN/GaN heterostructure nanowires (NWs) with a mean diameter down to 18 nm are investigated. Sharp emission lines originating from the recombination of localized excitons in the InGaN disk layer can be resolved. Excitation-dependent energy shifts, together with spe... [Phys. Rev. B 88, 155323] Published Mon Oct 28, 2013

Description: Analytical Chemistry DOI: 10.1021/ac202034k

Description: Background: HuR is an RNA-binding protein that post-transcriptionally modulates the expressions of various target genes implicated in carcinogenesis, such as CCNA2 encoding cyclin A. No prior study attempted to evaluate the significance of HuR expression in a large cohort with upper urinary tract urothelial carcinomas (UTUCs). Methods: In total, 340 cases of primary localized UTUC without previous or concordant bladder carcinoma were selected. All of these patients received ureterectomy or radical nephroureterectomy with curative intents. Pathological slides were reviewed, and clinical findings were collected. Immunostaining for HuR and cyclin A was performed and evaluated by using H-score. The results of cytoplasmic HuR and nuclear cyclin A expressions were correlated with disease-specific survival (DSS), metastasis-free survival (MeFS), urinary bladder recurrence-free survival (UBRFS), and various clinicopathological factors. Results: HuR cytoplasmic expression was significantly related to the pT status, lymph node metastasis, a higher histological grade, the pattern of invasion, vascular and perineurial invasion, and cyclin A expression (p = 0.005). Importantly, HuR cytoplasmic expression was strongly associated with a worse DSS (p 〈 0.0001), MeFS (p 〈 0.0001), and UBRFS (p = 0.0370) in the univariate analysis, and the first two results remained independently predictive of adverse outcomes (p = 0.038, relative risk [RR] = 1.996 for DSS; p = 0.027, RR = 1.880 for MeFS). Cyclin A nuclear expression was associated with a poor DSS (p = 0.0035) and MeFS (p = 0.0015) in the univariate analysis but was not prognosticatory in the multivariate analyses. High-risk patients (pT3 or pT4 with/without nodal metastasis) with high HuR cytoplasmic expression had better DSS if adjuvant chemotherapy was performed (p = 0.015). Conclusions: HuR cytoplasmic expression was correlated with adverse phenotypes and cyclin A overexpression and also independently predictive of worse DSS and MeFS, suggesting its roles in tumorigenesis or carcinogenesis and potentiality as a prognostic marker of UTUC. High HuR cytoplasmic expression might identify patients more likely to be beneficial for adjuvant chemotherapy.

Description: This study investigates the wind-induced splash in the Class A evaporation pan through a series of wind tunnel experiments. The experimental results revealed that high wind speed can generate seiche wave inside the pan and splash water out of the pan in several minutes. The splash loss increases as the wind speed increases, and the loss rate is at least one order of magnitude greater than the evaporation rate. In other words, the water loss from the pan is not entirely due to evaporation, and the evaporation rates under high wind speeds are over-estimated. By checking the wind speeds and evaporation rates from a four-year (2004–2008) field observation collected in northern Taiwan, it is found that the hourly evaporation rate was unusually high when wind speed was larger than 7 m s−1. The splash-out criterion is set as: hourly average wind speed U ≥ 7 m s−1 and evaporation rate E 〉 1.64 mm hr−1. The ratio of the splash-out to the average evaporation rate is 0.75% at this site. In addition, this study examines the influence of the initial water depth in the pan on the evaporation rate. The results demonstrate that, because of the shelter effect caused by the rim of the pan, the evaporation rates for water depth less than 8 cm are lower than that of standard water depth (20 cm) when wind speed U = 4 and 6 m s−1. However, the shelter effect becomes insignificant when wind speed was U = 2 m s−1.

Description: On 31 August 2010, more than 100 transient luminous events were observed to occur over Typhoon Lionrock when it passed at ∼210 km to the southwest of the NCKU site in Taiwan. Among them, 14 negative gigantic jets (GJs) with clear recognizable morphologies and radio frequency signals are analyzed. These GJs are all found to have negative discharge polarity and thus are type I GJs. Morphologically, they are grouped into three forms: tree-like, carrot-like, and a new intermediate type called tree-carrot-like GJs. The ULF and ELF/VLF band signals of these events contain clear signatures associated with GJ development stages, including the initiating lightning, the leading jet, the fully developed jet, and the trailing jet. Though the radio waveform for each group of GJs always contains a fast descending pulse linked with the surge current upon the GJ-ionosphere contact, the detailed waveforms actually vary substantially. Cross analysis of the optical and radio frequency signals for these GJs indicates that a large surge current moment (CM) (〉60 kA-km) appears to be essentially associated with the tree-like GJs. In contrast, the carrot-like and the tree-carrot-like GJs are both related to a surge CM less than 36 kA-km, and a continuing CM less than 27 kA-km further separates the carrot-like GJs from the tree-carrot-like GJs. Furthermore, on the peak CM versus charge moment change diagram for the initiating lightning, different groups of GJs seem to exhibit different trends. This feature suggests that the eventual forms of negative GJs may have been determined at the initiating lightning stage.