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  • 1
    Publication Date: 2011-05-14
    Description: Author(s): Isabella Gierz, Fabian Meier, J. Hugo Dil, Klaus Kern, and Christian R. Ast A giant spin splitting has been observed in surface alloys on noble metal (111) surfaces as a result of a strong structural modification at the surface as well as the large atomic spin-orbit interaction (SOI) of the alloy atoms. These surface alloys are an ideal playground to manipulate both the siz... [Phys. Rev. B 83, 195122] Published Fri May 13, 2011
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 2
    Publication Date: 2011-04-28
    Description: Author(s): Dandan Guan, Marco Bianchi, Shining Bao, Edward Perkins, Fabian Meier, J. Hugo Dil, Jürg Osterwalder, and Philip Hofmann The electron-phonon coupling strength of the ( sqrt[3] × sqrt[3] )R30^{°} Bi/Ag(111) surface alloy is investigated by temperature-dependent angle-resolved photoemission. The electron-phonon coupling strength for the Rashba-split surface state, as expressed by the mass-enhancement parameter λ, is ... [Phys. Rev. B 83, 155451] Published Wed Apr 27, 2011
    Keywords: Surface physics, nanoscale physics, low-dimensional systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 3
    Publication Date: 2011-10-20
    Description: A new general linear model of the climatology of the ionosphere's total electron content (TEC) is described, accounting simultaneously for the influences of solar and geomagnetic activity, oscillations at four frequencies and a secular trend. The model captures more than 98% of the variance in the daily averaged, global TEC derived from GPS observations during the 16 years from 1995 to 2010, and enables the reconstruction of TEC variations since 1950. Solar EUV irradiance variations, the dominant ionospheric influence, directly increase TEC by as much as 40 TECU from solar activity minimum to maximum and produce additional 27-day fluctuations of as much as 15 TECU (in October 2003). Semiannual and annual oscillations in TEC are comparable in magnitude to the 27-day fluctuations, with (peak to valley) amplitudes that increase from a few TECU at low solar activity to ∼17 TECU during solar activity maximum. The phase and amplitude of the semiannual oscillation are identical in the northern and southern geographic hemispheres (and hence globally). In contrast, the annual oscillation is twice as large in the southern hemisphere (where it peaks in December–January) than in the northern hemisphere (where it peaks in April–May). Seasonal, semiannual and annual anomalies in TEC are direct effects of semiannual and annual oscillations produced by orbitally driven photoionization and thermospheric composition changes, not of corresponding oscillations in solar or geomagnetic activity. Geomagnetic influences on daily averaged global TEC are relatively modest, with the maximum effect a reduction of 11 TECU (in October 2003) and only 11 episodes in excess of 5 TECU depletions during the past 16 years.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
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  • 4
    Publication Date: 2013-02-20
    Description: Multidrug-resistant Staphylococcus aureus infections pose a significant threat to human health. Antibiotic resistance is most commonly propagated by conjugative plasmids like pLW1043, the first vancomycin-resistant S. aureus vector identified in humans. We present the molecular basis for resistance transmission by the nicking enzyme in S. aureus (NES), which is essential...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 5
    Publication Date: 2012-11-28
    Description: Aims Patients with type 2 diabetes are at high risk for developing heart failure. Evidence-based treatment recommendations with respect to the specific benefits or possible hazards of antidiabetic treatment are scarce. Methods and results In a systematic search we only identified randomized, controlled trials for thiazolidinediones. Further evidence is largely based on subgroup analyses of larger intervention studies in mostly systolic heart failure, on observational studies, or on registries. Acknowledging this lack of data, hyperglycaemia should be treated to appropriate guideline-recommended targets and hypoglycaemia avoided until this evidence becomes available. Thiazolidinediones should not be used because of an increased event rate in diabetic patients with established heart failure and a large increase in incident heart failure. All other glucose-lowering strategies might be used in patients with diabetes and heart failure, but specific precautions must be considered. Conclusions The documented lack of data calls for specific trials, as diabetes and heart failure as well as their co-morbidities are highly prevalent and are becoming even more important with an increasing prevalence of obesity and an ageing population.
    Print ISSN: 1388-9842
    Electronic ISSN: 1879-0844
    Topics: Medicine
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  • 6
    Publication Date: 2014-07-19
    Description: We present a statistical attribution analysis of the changes in global annual average thermospheric mass density and ionospheric total electron content (TEC) between the cycle 22/23 solar minimum (which occurred at epoch 1996.4) and the prolonged cycle 23/24 minimum (2008.8). The mass density data are derived from orbital drag, and the TEC data are derived from ground-based GPS receivers. The inter-minima change in mass density was –36% relative to the 1996.4 yearly average. Considering each multiplicative forcing independently, lower average geomagnetic activity during the cycle 23/24 minimum produced an inter-minima density change of at least –14%, solar extreme ultraviolet (EUV) irradiance forcing produced a density change of –1% to –13%, and changes in thermospheric CO 2 concentration produced a density change of –5%. There was essentially no inter-minima change in global TEC derived from ground-based GPS receivers or spaced-based altimeters, even though past behavior suggests that it should have changed –3% (0.2 TEC units) in response to lower geomagnetic activity and –1% to –9% (0.1–0.8 TECU) in response to lower EUV irradiance. There is large uncertainty in the inter-minima change of solar EUV irradiance; the mass density and TEC data suggest a plausible range of 0% to –6%.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
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  • 7
    Publication Date: 2013-07-31
    Description: [1]  This paper supports studies of low frequency variability (LFV) within the thermosphere by deriving approximate integral and closed-form solutions of a nontrivial model of thermospheric temperature, density, and composition depending on altitude and time. We also provide a paradigm for applying dimensional analysis in such studies. The domain is the region between the mesopause and the exobase. The solutions emphasize the connectedness of the thermosphere, i.e., nonlocal influences of LFV in key physical parameters and phenomena. The present focus is seasonal variability (SV), within which the origin of a sizable semi-annual variation in the thermosphere remains under active investigation. Following from the thermodynamic differential equation for temperature is a filtered, integral solution consistent with the Π Theorem of dimensional analysis. A key result is the explicit demonstration that lower thermospheric boundary conditions affect low frequency variability throughout the thermosphere, making accurate boundary conditions essential to modeling LFV. In addition, LFV of the temperature varies inversely with variability of the net heating profile and has directly and inversely proportional contributions from variations in the thermal conductivity profile, which can include an " eddy diffusivity" component. Given a temperature profile, diffusive equilibrium defines model composition. For rapid calculations and transparency, we develop an approximate, closed-form solution for temperature, density, and composition depending only on a minimal set of observable parameters, and from that, we demonstrate the essential role of the phase and amplitude profile of the temperature LFV in determining the corresponding profile of variability in composition and density.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
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  • 8
    Publication Date: 2012-12-13
    Description: Author(s): J. D. Koralek, D. Meier, J. P. Hinton, A. Bauer, S. A. Parameswaran, A. Vishwanath, R. Ramesh, R. W. Schoenlein, C. Pfleiderer, and J. Orenstein We study the magnetic excitations of itinerant helimagnets by applying time-resolved optical spectroscopy to Fe 0.8 Co 0.2 Si. Optically excited oscillations of the magnetization in the helical state are found to disperse to lower frequency as the applied magnetic field is increased; the fingerprint of ... [Phys. Rev. Lett. 109, 247204] Published Wed Dec 12, 2012
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 9
    Publication Date: 2012-01-25
    Description: Nuclear factor κB (NF-κB) is a transcription factor that regulates various aspects of immune response, cell death, and differentiation as well as cancer. In this study we introduce the Py-Im polyamide 1 that binds preferentially to the sequences 5′-WGGWWW-3′ and 5′GGGWWW-3′. The compound is capable of binding to κB sites and reducing the expression of various NF-κB–driven genes including IL6 and IL8 by qRT-PCR. Chromatin immunoprecipitation experiments demonstrate a reduction of p65 occupancy within the proximal promoters of those genes. Genome-wide expression analysis by RNA-seq compares the DNA-binding polyamide with the well-characterized NF-κB inhibitor PS1145, identifies overlaps and differences in affected gene groups, and shows that both affect comparable numbers of TNF-α–inducible genes. Inhibition of NF-κB DNA binding via direct displacement of the transcription factor is a potential alternative to the existing antagonists.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 10
    Publication Date: 2012-03-14
    Description: Pyrrole–imidazole (Py–Im) hairpin polyamides are a class of programmable, sequence-specific DNA binding oligomers capable of disrupting protein–DNA interactions and modulating gene expression in living cells. Methods to control the cellular uptake and nuclear localization of these compounds are essential to their application as molecular probes or therapeutic agents. Here, we explore modifications of the hairpin -aminobutyric acid turn unit as a means to enhance cellular uptake and biological activity. Remarkably, introduction of a simple aryl group at the turn potentiates the biological effects of a polyamide targeting the sequence 5'-WGWWCW-3' (W = A/T) by up to two orders of magnitude. Confocal microscopy and quantitative flow cytometry analysis suggest this enhanced potency is due to increased nuclear uptake. Finally, we explore the generality of this approach and find that aryl-turn modifications enhance the uptake of all polyamides tested, while having a variable effect on the upper limit of polyamide nuclear accumulation. Overall this provides a step forward for controlling the intracellular concentration of Py–Im polyamides that will prove valuable for future applications in which biological potency is essential.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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