In:
Diabetes and Vascular Disease Research, SAGE Publications, Vol. 11, No. 5 ( 2014-09), p. 352-358
Abstract:
Hyperglycaemia is common among patients with critical neurological injury, even if they have no history of diabetes. The optimal target range for normalizing their blood glucose is unknown. Methods: Retrospective data were extracted from 890 hyperglycaemic individuals (glucose 〉 200 mg/dL) admitted to neuroscience critical care unit (NCCU) and these patients were divided into two groups: intensive glucose control group with target glucose of 〈 140 mg/dL achieved and moderate control with glucose levels 140-180 mg/dL. The groups were also stratified according to the hyperglycaemia type (pre-existing diabetes or stress-related). We defined the primary endpoint as death from any cause during NCCU admission. Results: In NCCU, tighter control of blood glucose at ≤ 140 mg/dL was associated with increased, mortality of individuals with pre-existing diabetes compared with moderate control [29 of 310 patients (9.4%) vs 15 of 304 patients (4.9%), p = 0.034] . Patient age [adjusted odds ratio (OR) = 1.12; 95% confidence interval (CI) = 1.05–1.19; p 〈 0.001], level of glycated haemoglobin (adjusted OR = 1.24; 95% CI = 1.04–1.48; p = 0.017) and hypoglycaemia (adjusted OR = 10.3; 95% CI = 2.92–36.6; p 〈 0.001) were positively associated with higher mortality. Death rate was lower among stress-related hyperglycaemic patients with tighter glucose controlled at ≤ 140 mg/dL [6 of 140 patients (4.3%) vs 15 of 136 patients (11.0%), p = 0.035]. Conclusion: A differential association is evident between glucose levels and mortality in diabetes and stress-related hyperglycaemia patients. However, given the observational nature of our work, no clinical recommendations can be given and prospective studies are required to further investigate these findings.
Type of Medium:
Online Resource
ISSN:
1479-1641
,
1752-8984
DOI:
10.1177/1479164114530580
Language:
English
Publisher:
SAGE Publications
Publication Date:
2014
detail.hit.zdb_id:
2250797-8
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