In:
Journal of Labelled Compounds and Radiopharmaceuticals, Wiley, Vol. 56, No. 1 ( 2013-01), p. 1-5
Abstract:
This study reports the synthesis and evaluation studies of 6′‐cyclopentadienyl tricarbonyl technetium‐99m 6′‐oxo‐11‐(hexanamide)undecanoic acid (1). 1 was prepared with 26.5 ± 4.3% of radiochemical yield and more than 98% of radiochemical purity. Tissue distribution in mice showed that high radioactivity accumulated in the heart with moderate clearance. However, unfortunately, similar to those of other technetium‐labeled fatty acid analogs, the biodistribution studies of 1 in mice showed poor heart‐to‐blood ratios, which suggested that 1 cannot be used as myocardial imaging agent, and it may provide a theoretical basis or a lab experience for corresponding fatty acid tracers studies.
Type of Medium:
Online Resource
ISSN:
0362-4803
,
1099-1344
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
1491841-9
SSG:
15,3
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