In:
The British Journal of Diabetes & Vascular Disease, SAGE Publications, Vol. 11, No. 5 ( 2011-09), p. 249-252
Abstract:
This study investigated whether serum C-reactive protein (CRP) concentration is increased in patients with type 1 diabetes mellitus with a normal body mass index (BMI) and whether BMI, glycated haemoglobin (HbA 1c ) and CRP are correlated in patients with type 1 diabetes. High-sensitivity CRP was determined by immunonephelometry and HbA 1c by an immunoturbidimetric method in 30 patients with type 1 diabetes and 30 healthy individuals matched for age, sex and BMI. Median serum CRP concentration in patients with type 1 diabetes (1.34 mg/L) was significantly higher than healthy individuals (0.2 mg/L; p 〈 0.0001). Positive correlation between CRP and BMI was observed (rho=0.598; p 〈 0.0001), but no significant correlation was observed between CRP and HbA 1c (rho=0.285; p=NS) in patients with type 1 diabetes. Increased CRP levels in type 1 diabetes patients do not appear to be associated with glycaemic control, and may reflect low-grade inflammation associated with atherosclerosis, as well as activation of innate immune activity.
Type of Medium:
Online Resource
ISSN:
1474-6514
,
1753-4305
DOI:
10.1177/1474651411420454
Language:
English
Publisher:
SAGE Publications
Publication Date:
2011
detail.hit.zdb_id:
2429646-6
detail.hit.zdb_id:
3018522-1
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