In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 73, No. 24_Supplement ( 2013-12-15), p. P1-08-17-P1-08-17
Abstract:
Background Triple negative breast cancer (TNBC) has responded well in the neoadjuvant setting, with rates of pathologic complete response (pCR) commonly higher than for other breast tumor types. However, more than half of TNBC patients do not achieve a pCR and have a very poor prognosis. Cluster analysis identified 6 TNBC subtypes displaying unique gene expression, including basal-like and a mesenchymal stem-like (claudin-low) subtype. The object of this study was to evaluate the clinical utility of claudin-3 and basal-markers expressions in the prediction of pCR and prognosis in a cohort of breast cancer patients receiving the combination of taxane and anthracycline as neoadjuvant chemotherapy. Materials and Methods A prospective data base of 412 Japanese women with stage I/II/III breast cancer who received neoadjuvant chemotherapy was analyzed. The regimens were 6 cycles of concurrent administration of doxorubicin (50 mg/m2) and docetaxel (60 mg/m2) or 4 cycles of epirubicin (100 mg/m2), 5-fluorouracil (500 mg/m2), and cyclophosphamide (500 mg/m2) followed by 4 cycles of docetaxel (100 mg/m2). We performed immunohistochemical staining for ER, PgR, HER2, epidermal growth factor receptor (EGFR), cytokeratin 5/6 and claudin-3 using specimens obtained at diagnosis by core needle biopsy. Based on immunoreactivity, TNBC tumors were classified into basal/claudin-high (BCH), basal/claudin-low (BCL), non-basal/claudin-high (NBCH) and non-basal/claudin-low (NBCL). Results The overall pCR of this patient cohort was 19%. pCR was observed 30 cases of 84 TNBC (36%) and 50 cases of 328 non-TNBC (15%)(p & lt;0.0001). Among the TNBC tumors, pCR rate was significantly different between subgroups. BCH 50%, BCL 23%, NBCH 83% and NBCL 43% (p = 0.039). The 5-year overall survival rate was significantly different between TNBC and non-TNBC. TNBC 81% and non-TNBC 94% (p = 0.0017). The 5-year overall survival rate was different between triple-negative subgroups. BCH 92%, BCL 78%, NBCH 83% and NBCL 46%. Conclusions This study indicated that claudin-3 and basal-markers might be predictive biomarkers of pCR and prognosis in triple negative breast cancer patients treated with neoadjuvant chemotherapy. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-08-17.
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/0008-5472.SABCS13-P1-08-17
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2013
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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