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  • 1
    Online Resource
    Online Resource
    Evaluation of Laparoscopic‐Assisted Ovariohysterectomy for Treatment of Canine Pyometra
    Wiley ; 2013
    In:  Veterinary Surgery Vol. 42, No. 5 ( 2013-06), p. 572-578
    Details
    In: Veterinary Surgery, Wiley, Vol. 42, No. 5 ( 2013-06), p. 572-578
    Abstract: To describe a technique for treating pyometra in dogs using a 3‐portal laparoscopic‐assisted ovariohysterectomy (LAOVH) and evaluate outcome. Study Design Retrospective case series. Animals Dogs (n = 12). Methods Dogs with open or closed‐cervix pyometra with moderately sized (1–4 cm) uterine horn diameters based on preoperative ultrasonography and no evidence of perforation were included in the study. A 3‐portal technique for LAOVH was used. A wound retraction device was inserted into the caudal portal after enlargement of the incision to 3–4 cm to simplify removal of the uterus with minimal tension. Results Twelve dogs (median weight, 23.3 kg; range, 2.1–46.0 kg) met the inclusion criteria. Median uterine diameter was 3.0 cm (range, 1.2–4.0 cm). Median surgical time for LAOVH was 107 minutes (range, 82–120 minutes). Complications included mild hemorrhage from the uterine vessels in 1 dog during uterine removal through the wound retraction device and intra‐abdominal uterine rupture in 1 dog which necessitated conversion to an open approach. All dogs recovered from surgery and were discharged. Conclusions LAOVH can be used for treatment of select cases of canine pyometra. Careful case selection is mandatory to improve success and minimize conversion to an open approach. Gentle handling of the reproductive organs is imperative to avoid iatrogenic uterine rupture.
    Type of Medium: Online Resource
    ISSN: 0161-3499 , 1532-950X
    URL: Issue
    URL: Article
    DOI: 10.1111/vsu.v42.5
    DOI: 10.1111/j.1532-950X.2013.12012.x
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 1491071-8
    SSG: 22
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  • 2
    Online Resource
    Online Resource
    Evaluation of single port access gastropexy and ovariectomy using articulating instruments and angled telescopes in dogs
    Wiley ; 2013
    In:  Veterinary Surgery Vol. 42, No. 7 ( 2013-10), p. 807-813
    Details
    In: Veterinary Surgery, Wiley, Vol. 42, No. 7 ( 2013-10), p. 807-813
    Abstract: To describe in dogs, a technique for single port access gastropexy and ovariectomy (SPAGO) using a commercially available multitrocar port and to evaluate short‐term outcome. Design Retrospective case series. Animals Dogs (n = 18). Procedures A commercially available multitrocar port was inserted into the abdomen lateral to the rectus abdominis muscle and 2–5 cm caudal to the right rib. Dogs were tilted 45° in both left and right recumbency and bilateral ovariectomy performed using articulating graspers, a bipolar vessel sealing device and a 30° telescope. The laparoscopic assisted incisional gastropexy was performed after ovariectomy at the multitrocar port insertion site by grasping the antral portion of the stomach with a 10 mm DuVall forceps and suturing the seromuscular layer of the antral region of the stomach to the transversus abdominis muscle. Results Eighteen dogs (median weight, 34.5 kg; range, 14.7–59.2 kg) met the inclusion criteria. Median surgical time for SPAGO was 65 minutes (range, 50–225 minutes). Intra‐operative complications included, incorrect multitrocar port placement location (n = 3) and mild hemorrhage from a splenic laceration (1) All dogs recovered from surgery and were discharged from the hospital. Conclusions Single port access gastropexy and ovariectomy is a feasible procedure to provide prophylaxis against gastric dilation‐volvulus and a simultaneous means of sterilization in female dogs. Careful and accurate initial multitrocar port insertion is necessary to have optimal operative viewing as well as to reduce the chances of inadvertent splenic laceration.
    Type of Medium: Online Resource
    ISSN: 0161-3499 , 1532-950X
    URL: Issue
    URL: Article
    DOI: 10.1111/vsu.v42.7
    DOI: 10.1111/j.1532-950X.2013.12036.x
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 1491071-8
    SSG: 22
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  • 3
    Online Resource
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    Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin‐2 expression in peri‐tumourous liver correlates with increased survival
    Wiley ; 2013
    In:  Liver International Vol. 33, No. 9 ( 2013-10), p. 1428-1440
    Details
    In: Liver International, Wiley, Vol. 33, No. 9 ( 2013-10), p. 1428-1440
    Abstract: Hepatocellular carcinoma ( HCC ) is a malignant tumour that is characterized by extensive vascular remodelling and responsiveness to treatment with the anti‐angiogenic multikinase inhibitor sorafenib. The aim was to study endothelial remodelling in HCC . Methods The murine inducible albumin‐ SV 40‐large T‐antigen model and two tissue microarrays ( TMA ) with 295 tumourous and 83 peri‐tumourous samples of 296 patients with HCC were analysed for expression of liver sinusoidal endothelial cell ( LSEC )‐specific marker proteins, stabilin‐1 and stabilin‐2, LYVE ‐1 and CD 32b. Results LSEC marker proteins were sequentially lost during HCC progression in the murine HCC model being absent from tumour nodules larger than 800 μm in diameter. Similarly, the TMA analysis of human HCC s revealed loss of all four marker proteins in the majority of tumourous tissue samples. Preservation of LYVE ‐1 expression showed a significant correlation with low grading (G1). In corresponding peri‐tumourous liver tissue, loss of all marker proteins was seen in a minor proportion of cases (34%) while the majority of cases retained expression of at least one of the marker proteins. Loss of stabilin‐2 expression in peri‐tumourous liver tissue of patients with HCC was significantly less likely to occur (38%) than loss of the other marker proteins (63–95%) and it was associated with significantly longer tumour‐specific ( P  = 0.0523) and overall ( P  = 0.0338) survival. Loss of stabilin‐2 may enhance survival in HCC by preventing endothelial‐tumour cell adhesive interactions and microvascular invasion. Conclusions In summary, endothelial transdifferentiation is a major pathogenic event in HCC development indicating a switch from vessel co‐option/intussusceptive angiogenesis to sprouting angiogenesis.
    Type of Medium: Online Resource
    ISSN: 1478-3223 , 1478-3231
    URL: Issue
    URL: Article
    DOI: 10.1111/liv.2013.33.issue-9
    DOI: 10.1111/liv.12262
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2124684-1
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  • 4
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    Online Resource
    Evaluation of coagulation in dogs with partial or complete extrahepatic biliary tract obstruction by means of thromboelastography
    American Veterinary Medical Association (AVMA) ; 2013
    In:  Journal of the American Veterinary Medical Association Vol. 242, No. 6 ( 2013-03-15), p. 778-785
    Details
    In: Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), Vol. 242, No. 6 ( 2013-03-15), p. 778-785
    Abstract: Objective —To characterize in vitro coagulation status in a cohort of dogs with extrahepatic biliary tract obstruction (EHBO) and to evaluate these patients for hypercoagulability by means of thromboelastography. Design —Prospective cohort study. Animals —10 dogs with EHBO and 19 healthy control dogs. Procedures —Partial or complete EHBO was confirmed via exploratory celiotomy. Venous blood samples were collected for evaluation of prothrombin time (PT) and activated partial thromboplastin time (APTT); fibrinogen and D-dimer concentrations; protein C and antithrombin activities; and factor VII, VIII, and XI coagulant activities in plasma as well as thromboelastography in whole blood. Thromboelastography variables were measured from the thromboelastography tracing, and a coagulation index was calculated. Thromboelastography results were compared with those of healthy control dogs previously evaluated by the same laboratory. Results —Hypercoagulability was diagnosed in all dogs with EHBO on the basis of a high coagulation index. Thromboelastography variables, including maximal amplitude, α-angle, and coagulation index, were significantly higher, and K (clot formation time) and R (reaction time) were significantly lower in these dogs than in control dogs. All dogs with EHBO had PT and APTT within respective reference ranges. Plasma D-dimer and fibrinogen concentrations were above reference ranges in 8 and 7 dogs, respectively, and protein C and antithrombin activities were below reference ranges in 3 and 1 dogs, respectively. Conclusions and Clinical Relevance —In vitro hypercoagulability was commonly detected in dogs with naturally occurring EHBO. The traditional view of EHBO as a disease that causes hypocoagulability may need to be reconsidered.
    Type of Medium: Online Resource
    ISSN: 0003-1488
    URL: Article
    DOI: 10.2460/javma.242.6.778
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2013
    detail.hit.zdb_id: 2904887-4
    SSG: 22
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  • 5
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    Online Resource
    Laparoscopic treatment of ovarian remnant syndrome in dogs and cats: 7 cases (2010–2013)
    American Veterinary Medical Association (AVMA) ; 2014
    In:  Journal of the American Veterinary Medical Association Vol. 245, No. 11 ( 2014-12-01), p. 1251-1257
    Details
    In: Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), Vol. 245, No. 11 ( 2014-12-01), p. 1251-1257
    Abstract: Objective —To describe the technique and evaluate the outcome of laparoscopic treatment of ovarian remnant syndrome (ORS) in dogs and cats. Design —Retrospective case series. Animals —7 client-owned dogs and cats. Procedures —Medical records of dogs and cats with ORS that were treated laparoscopically at 3 large veterinary teaching hospitals were reviewed. Laparoscopic ovarian remnant resection was performed by means of either a 3-port or single-port technique with the patient in dorsal recumbency. The area caudal to both kidneys was thoroughly inspected for evidence of ovarian tissue by tilting the patient laterally. Any ovarian remnant tissue in these areas was resected with a bipolar vessel sealer. Results —5 female dogs and 2 female cats that had previously undergone ovariectomy or ovariohysterectomy were included in the study. Six procedures were performed with a standard 3-port technique, and 1 was performed with a single-port technique. Median surgery time was 90 minutes (range, 50 to 150 minutes). No patient required conversion to laparotomy. Six of the 7 patients had complete resolution of clinical signs after surgery. One patient underwent laparotomy 7 weeks after surgery for management of stump pyometra, but no further ovarian tissue was detected. Conclusions and Clinical Relevance —Laparoscopic management of ORS in this cohort of dogs and cats was associated with minimal morbidity. Laparoscopic treatment of ORS in dogs and cats may be recommended for appropriately selected patients.
    Type of Medium: Online Resource
    ISSN: 0003-1488
    URL: Article
    DOI: 10.2460/javma.245.11.1251
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2014
    detail.hit.zdb_id: 2904887-4
    SSG: 22
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  • 6
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    Transvesicular percutaneous cystolithotomy for the retrieval of cystic and urethral calculi in dogs and cats: 27 cases (2006–2008)
    American Veterinary Medical Association (AVMA) ; 2011
    In:  Journal of the American Veterinary Medical Association Vol. 239, No. 3 ( 2011-08-01), p. 344-349
    Details
    In: Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), Vol. 239, No. 3 ( 2011-08-01), p. 344-349
    Abstract: Objective —To describe the use of transvesicular percutaneous cystolithotomy for the retrieval of cystic and urethral calculi and to report the outcome in dogs and cats. Design —Retrospective case series. Animals —23 dogs and 4 cats. Procedures —Medical records were reviewed for signalment, procedure time, stone number, stone location, pre- and postoperative radiographs, procedure-associated complications, and short-term outcome. A ventral midline approach was made into the abdomen over the urinary bladder apex. A screw cannula was inserted at the bladder apex for normograde rigid and flexible cystourethroscopy. All uroliths were removed via a stone basket device and retrograde flushing and suction. Long-term follow-up (1 year after surgery) information was obtained by telephone or e-mail contact with owners. Results —27 animals with cystic and urethral calculi were included. Median patient weight was 8.3 kg (18.3 lb; range, 1.8 to 42.6 kg [4.0 to 93.7 lb]). Urolith number ranged from 1 to 〉 35 (median, 7). Urolith size ranged from 〈 1 to 30 mm (median, 4.5 mm). Fifteen of the 27 animals had a previous cystotomy (range, 1 to 5 procedures). Median procedure time was 66 minutes (range, 50 to 80 minutes). All patients were discharged within 24 hours. No postoperative complications were reported at the time of suture removal. At the time of long-term follow-up, the 22 clients that could be contacted were satisfied with the procedure. Conclusions and Clinical Relevance —Transvesicular percutaneous cystolithotomy may decrease the need for urethrotomy, serial transurethral endoscopic procedures, and abdominal insufflation associated with other minimally invasive interventions currently available. This procedure also provided excellent visualization for bladder and urethral luminal inspection.
    Type of Medium: Online Resource
    ISSN: 0003-1488
    URL: Article
    DOI: 10.2460/javma.239.3.344
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2011
    detail.hit.zdb_id: 2904887-4
    SSG: 22
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  • 7
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    Online Resource
    National and European identities and political support for the European Union within the context of the economic and financial crisis
    Springer Science and Business Media LLC ; 2014
    In:  Zeitschrift für Vergleichende Politikwissenschaft Vol. 8, No. S2 ( 2014-11), p. 55-78
    Details
    In: Zeitschrift für Vergleichende Politikwissenschaft, Springer Science and Business Media LLC, Vol. 8, No. S2 ( 2014-11), p. 55-78
    Type of Medium: Online Resource
    ISSN: 1865-2646 , 1865-2654
    URL: Article
    DOI: 10.1007/s12286-014-0207-8
    RVK:
    ME 1000
    Language: German
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2014
    detail.hit.zdb_id: 2409798-6
    SSG: 3,6
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  • 8
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    Material properties and electrical stimulation regimens of polycaprolactone fumarate–polypyrrole scaffolds as potential conductive nerve conduits
    Elsevier BV ; 2011
    In:  Acta Biomaterialia Vol. 7, No. 3 ( 2011-03), p. 944-953
    Details
    In: Acta Biomaterialia, Elsevier BV, Vol. 7, No. 3 ( 2011-03), p. 944-953
    Type of Medium: Online Resource
    ISSN: 1742-7061
    URL: Article
    DOI: 10.1016/j.actbio.2010.10.013
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2011
    detail.hit.zdb_id: 2173841-5
    SSG: 12
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  • 9
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    Single-port laparoscopic cryptorchidectomy in dogs and cats: 25 cases (2009–2014)
    American Veterinary Medical Association (AVMA) ; 2014
    In:  Journal of the American Veterinary Medical Association Vol. 245, No. 11 ( 2014-12-01), p. 1258-1265
    Details
    In: Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), Vol. 245, No. 11 ( 2014-12-01), p. 1258-1265
    Abstract: Objective —To describe the operative technique for single-port laparoscopic cryptorchidectomy (SPLC) in dogs and cats and evaluate clinical outcome for patients that underwent the procedure. Design —Retrospective case series. Animals —25 client-owned dogs (n = 22) and cats (3). Procedures —Dogs and cats that underwent SPLC with 3 commercially available single-port devices between 2009 and 2014 were retrospectively identified through a multi-institutional medical records review. Surgery was performed via a single-port device placed through a 1.5- to 3.0-cm abdominal incision either at the region of the umbilicus or caudal to the right 13th rib. The cryptorchidectomy was performed with graspers, a bipolar vessel sealing device, and a 30° telescope. Results —SPLC was performed with a single-incision laparoscopic surgery port (n = 15), a multitrocar wound-retractor access system (8), or a metal resterilizable single-port access device (2). Median age was 365 days (range, 166 to 3,285 days). Median body weight was 18.9 kg (41.6 lb; range, 1.3 to 70 kg [2.9 to 154 lb]). Median surgical time was 38 minutes (range, 15 to 70 minutes). Thirty-two testes were removed (12 left, 6 right, and 7 bilateral). Four patients had 1 additional abdominal surgical procedure performed concurrently during SPLC. No intraoperative or postoperative complications were encountered. Conclusions and Clinical Relevance —Results suggested that SPLC can be performed in a wide range of dogs and cats with cryptorchidism and can be combined with other elective laparoscopic surgical procedures. The SPLC technique was associated with a low morbidity rate and provided a potentially less invasive alternative to traditional open and multiport laparoscopic techniques.
    Type of Medium: Online Resource
    ISSN: 0003-1488
    URL: Article
    DOI: 10.2460/javma.245.11.1258
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2014
    detail.hit.zdb_id: 2904887-4
    SSG: 22
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  • 10
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    Quantitative real-time PCR and phase specific serology are mutually supportive in Q fever diagnostics in goats
    Elsevier BV ; 2013
    In:  Veterinary Microbiology Vol. 167, No. 3-4 ( 2013-12), p. 600-608
    Details
    In: Veterinary Microbiology, Elsevier BV, Vol. 167, No. 3-4 ( 2013-12), p. 600-608
    Type of Medium: Online Resource
    ISSN: 0378-1135
    URL: Article
    DOI: 10.1016/j.vetmic.2013.09.015
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
    detail.hit.zdb_id: 1498996-7
    SSG: 22
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