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  • 2010-2014  (2)
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  • 2010-2014  (2)
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  • 1
    Online Resource
    Online Resource
    A functional MRI study of the relationship between naming treatment outcomes and resting state functional connectivity in post‐stroke aphasia
    Wiley ; 2014
    In:  Human Brain Mapping Vol. 35, No. 8 ( 2014-08), p. 3919-3931
    Details
    In: Human Brain Mapping, Wiley, Vol. 35, No. 8 ( 2014-08), p. 3919-3931
    Abstract: The majority of studies investigating the neural mechanisms underlying treatment in people with aphasia have examined task‐based brain activity. However, the use of resting‐state fMRI may provide another method of examining the brain mechanisms responsible for treatment‐induced recovery, and allows for investigation into connectivity within complex functional networks Methods Eight people with aphasia underwent 12 treatment sessions that aimed to improve object naming. Half the sessions employed a phonologically‐based task, and half the sessions employed a semantic‐based task, with resting‐state fMRI conducted pre‐ and post‐treatment. Brain regions in which the amplitude of low frequency fluctuations (ALFF) correlated with treatment outcomes were used as seeds for functional connectivity (FC) analysis. FC maps were compared from pre‐ to post‐treatment, as well as with a group of 12 healthy older controls Results Pre‐treatment ALFF in the right middle temporal gyrus (MTG) correlated with greater outcomes for the phonological treatment, with a shift to the left MTG and supramarginal gyrus, as well as the right inferior frontal gyrus, post‐treatment. When compared to controls, participants with aphasia showed both normalization and up‐regulation of connectivity within language networks post‐treatment, predominantly in the left hemisphere Conclusions The results provide preliminary evidence that treatments for naming impairments affect the FC of language networks, and may aid in understanding the neural mechanisms underlying the rehabilitation of language post‐stroke. Hum Brain Mapp 35:3919–3931, 2014 . © 2014 Wiley Periodicals, Inc .
    Type of Medium: Online Resource
    ISSN: 1065-9471 , 1097-0193
    URL: Issue
    URL: Article
    DOI: 10.1002/hbm.v35.8
    DOI: 10.1002/hbm.22448
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 1492703-2
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  • 2
    Online Resource
    Online Resource
    Changes in White Matter Connectivity Following Therapy for Anomia Post stroke
    SAGE Publications ; 2014
    In:  Neurorehabilitation and Neural Repair Vol. 28, No. 4 ( 2014-05), p. 325-334
    Details
    In: Neurorehabilitation and Neural Repair, SAGE Publications, Vol. 28, No. 4 ( 2014-05), p. 325-334
    Abstract: Background. The majority of studies investigating the neural mechanisms underlying treatment-induced recovery in aphasia have focused on the cortical regions associated with language processing. However, the integrity of the white matter connecting these regions may also be crucial to understanding treatment mechanisms. Objective. This study investigated the integrity of the arcuate fasciculus (AF) and uncinate fasciculus (UF) before and after treatment for anomia in people with aphasia. Method. Eight people with aphasia received 12 treatment sessions to improve naming; alternating between phonologically-based and semantic-based tasks, with high angular resolution diffusion imaging conducted pre and post treatment. The mean generalized fractional anisotropy (GFA), a measure of fiber integrity, and number of fibers in the AF and UF were compared pre and post treatment, as well as with a group of 14 healthy older controls. Results. Pre treatment, participants with aphasia had significantly fewer fibers and lower mean GFA in the left AF compared with controls. Post treatment, mean GFA increased in the left AF to be statistically equivalent to controls. Additionally, mean GFA in the left AF pre and post treatment positively correlated with maintenance of the phonologically based treatment. No differences were found in the right AF, or the UF in either hemisphere, between participants with aphasia and controls, and no changes were observed in these tracts following treatment. Conclusions. Anomia treatments may improve the integrity of the white matter connecting cortical language regions. These preliminary results add to the understanding of the mechanisms underlying treatment outcomes in people with aphasia post stroke.
    Type of Medium: Online Resource
    ISSN: 1545-9683 , 1552-6844
    URL: Article
    DOI: 10.1177/1545968313508654
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2100545-X
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