In:
Acta Chimica Slovaca, Walter de Gruyter GmbH, Vol. 6, No. 1 ( 2013-04-1), p. 55-59
Abstract:
The metal complexes have a significant role in photodynamic therapy (PDT). The most common metals studied for PDT of tumors are transitional metals. In this paper we have studied the copper(II) complexes of N-salicyliden-L-glutamate. The photocytostatic effect was monitored against mouse leukemic cell line L1210. Photocytostatic effect was confirmed for [Cu(N-salicyliden-L-glutamato・2H 2 O]・isoquinoline (CuCIQ), but it wasn’t observed for the parental molecule [Cu(N-salicyliden-L-glutamato・2H 2 O]・H 2 O. CuCIQ had photocytotoxic effect already at 10 μM concentration. Irradiated cells (1050 mJ.cm -2 , λ = 365 nm) had half the viability of the cells incubated with CuCIQ in the dark (72 h). Co-incubation of the cells with CuCIQ and ascorbic acid increased this photocytotoxic effect and this effect correlated with the elevated level of lipoperoxidation.
Type of Medium:
Online Resource
ISSN:
1337-978X
DOI:
10.2478/acs-2013-0010
Language:
Unknown
Publisher:
Walter de Gruyter GmbH
Publication Date:
2013
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