In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 30, No. 15_suppl ( 2012-05-20), p. e15179-e15179
Abstract:
e15179 Background: Conflicting reports exist on associations between ADT and CVR in PC patients (pts). The current study tests the hypothesis that underutilization of CMeds in PC pts with known CVR contributes to their increased cardiac event rates. Methods: Veteran men without malignancy (no-PC, controls) and men with PC on ADT (cases) were consented through the IUSCC IRB-approved biorepository protocol. All pts had high CVR defined as the presence of 〉 2 of the following: age 〉 45, Body mass index (BMI) 〉 30 kg/m 2 , hypertension (HTN), hyperlipidemia (HL), diabetes (DM), and smoking history (SmHx). Prior coronary artery disease (CAD) qualified pts as severe CVR. Each case was matched with 2 controls in the following order of priority: prior CAD, HTN, DM, HL, SmHx, age, BMI, and race. CMeds prescriptions included in the table below were verified via VAMC pharmacy records. CMeds prescription differences between cases and controls were tested by one-sided chi-Squared testing for each medication and by logistic regression for different classes of medications. Results: Between 1/2007 and 6/2011, 53 cases and 254 controls were enrolled in the IUSCC VAMC clinics. After 2:1 matching, the final cohort included 53 cases and 106 controls. Demographics included: prior CAD – 27%, HTN – 60%, DM – 31%, HL – 40%, SmHx – 63%, BMI – median 29.7 kg/m 2 , Age – median 66 yrs. Controls were younger than cases (71.4 yrs cases – 63.1 yrs controls, p 〈 0.0001). No statistically significant differences in CMed prescribing frequency were observed between the two groups. Conclusions: Differences in CMed prescribing practices between PC pts and no-PC men with high CVR is not a factor contributing to increased cardiac events in PC pts on ADT in our Veteran population. The study size warrants confirmation in a larger dataset. [Table: see text]
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/jco.2012.30.15_suppl.e15179
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2012
detail.hit.zdb_id:
2005181-5
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