In:
Journal of the American Geriatrics Society, Wiley, Vol. 60, No. 8 ( 2012-08), p. 1515-1520
Abstract:
To investigate whether higher intake of potassium, calcium, and magnesium reduces the risk of incident dementia. Design Prospective cohort study. Setting The H isayama S tudy, in J apan. Participants One thousand eighty‐one community‐dwelling Japanese individuals without dementia aged 60 and older. Measurements A 70‐item semiquantitative food frequency questionnaire was used to assess potassium, calcium, and magnesium intakes. Hazard ratios ( HR s) for the development of all‐cause dementia and its subtypes were estimated using C ox proportional hazards model. Results During a 17‐year follow‐up, 303 participants experienced all‐cause dementia; of these, 98 had vascular dementia ( V a D ), and 166 had A lzheimer's disease ( AD ). The multivariable‐adjusted HR s for the development of all‐cause dementia were 0.52 (95% confidence interval [ CI ] = 0.30–0.91), 0.64 (95% CI = 0.41–1.00), and 0.63 (95% CI = 0.40–1.01) for the highest quartiles of potassium, calcium, and magnesium intake, respectively, compared with the corresponding lowest quartiles. Similarly, the HR s for the development of V a D were 0.20 (95% CI = 0.07–0.56), 0.24 (95% CI = 0.11–0.53), and 0.26 (95% CI = 0.11–0.61) for the highest quartiles of potassium, calcium, and magnesium intake, respectively. There was no evidence of a linear association between these mineral intakes and the risk of AD . Conclusion Higher self‐reported dietary intakes of potassium, calcium, and magnesium reduce the risk of all‐cause dementia, especially V a D , in the general Japanese population.
Type of Medium:
Online Resource
ISSN:
0002-8614
,
1532-5415
DOI:
10.1111/jgs.2012.60.issue-8
DOI:
10.1111/j.1532-5415.2012.04061.x
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2040494-3
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