In:
mBio, American Society for Microbiology, Vol. 4, No. 6 ( 2013-12-31)
Kurzfassung:
The human polyomaviruses JC polyomavirus (JCPyV) and BK polyomavirus (BKPyV) cause rare but severe diseases in individuals with reduced immune function. During immunosuppression, JCPyV disseminates from the kidney to the central nervous system and destroys oligodendrocytes, resulting in the fatal disease progressive multifocal leukoencephalopathy. Kidney transplant recipients are at increased risk of BKPyV-induced nephropathy, which results in kidney necrosis and loss of the transplanted organ. There are currently no effective therapies for JCPyV and BKPyV. We show that a small molecule named retro-2 cycl protects cells from infection with JCPyV and BKPyV by inhibiting intracellular viral transport. Retro-2 cycl treatment reduces viral spreading in already established infections and may therefore be able to control infection in affected patients. Further optimization of retro-2 cycl may result in the development of an effective antiviral therapy directed toward pathogens that use retrograde trafficking to infect their hosts.
Materialart:
Online-Ressource
ISSN:
2161-2129
,
2150-7511
DOI:
10.1128/mBio.00729-13
Sprache:
Englisch
Verlag:
American Society for Microbiology
Publikationsdatum:
2013
ZDB Id:
2557172-2
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