In:
International Journal of Cancer, Wiley, Vol. 134, No. 6 ( 2014-03-15), p. 1311-1322
Abstract:
What's new? ALX4 is a putative transcription factor involved in epithelial development. In this study, the authors examined whether the methylation status and function of ALX4 might play a role in lung cancer. They found that ALX4 was preferentially methylated in lung cancer, via CpG‐island hypermethylation. This, in turn resulted in a loss of ALX4 expression. When ALX4 was restored, it induced apoptosis and suppressed tumorigenicity in mice. These findings indicate that ALX4 acts as a novel tumor suppressor in lung cancer, which may aid in early detection and provide a potential therapeutic target.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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