In:
BioMed Research International, Hindawi Limited, Vol. 2014 ( 2014), p. 1-6
Abstract:
Hyperhomocysteinemia is strongly associated with cardiovascular diseases. Previous studies have shown that phytoestrogen α -zearalanol can protect cardiovascular system from hyperhomocysteinemia and ameliorate the level of plasma total homocysteine; however, the underlying mechanisms remain to be clarified. The aim of this research is to investigate the possible molecular mechanisms involved in ameliorating the level of plasma homocysteine by α -zearalanol. By the successfully established diet-induced hyperhomocysteinemia rat models, we found that, after α -zearalanol treatment, the activity of cystathionine β -synthase, the key enzyme in homocysteine metabolism, was significantly elevated and level of nitrative stress in liver was significantly reduced. In correlation with this, results also showed a decreased nitration level of cystathionine β -synthase in liver. Together data implied that alleviation of plasma homocysteine level by phytoestrogen α -zearalanol might be related to the reduction of cystathionine β -synthase nitration.
Type of Medium:
Online Resource
ISSN:
2314-6133
,
2314-6141
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2014
detail.hit.zdb_id:
2698540-8
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