In:
EMBO Molecular Medicine, EMBO, Vol. 6, No. 1 ( 2014-01), p. 80-98
Abstract:
image PPARβ/δ regulates Src gene expression and activity in response to UV. In human skin cancer PPARβ/δ expression was also positively correlated with SRC expression with interaction between PPARβ/δ, SRC and TGFβ1 at the transcriptional level. Expression of the oncogene Src is stimulated by PPARβ/δ through a direct transcriptional mechanism Progression of UV‐induced skin cancer is enhanced by PPARβ/δ ‐ Src signaling Markers of the epithelial‐to‐mesenchymal transition (EMT) are increased in keratinocytes by the PPARβ/δ ‐ Src pathway In human skin squamous cell carcinoma (SCCs), there is a positive correlation between the gene expression of PPARβ/δ, Src and EMT markers
Type of Medium:
Online Resource
ISSN:
1757-4676
,
1757-4684
DOI:
10.1002/emmm.201302666
Language:
English
Publisher:
EMBO
Publication Date:
2014
detail.hit.zdb_id:
2485479-7
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