In:
Macromolecular Chemistry and Physics, Wiley, Vol. 211, No. 21 ( 2010-11), p. 2292-2300
Abstract:
A series of amphiphilic random copolymers with MPC as the hydrophilic segment, SMA as the hydrophobic segment and GMA as the reactive segment were synthesized. Polymeric micelles with different sizes were obtained through tuning the hydrophilic/hydrophobic segment ratios in the copolymers. The formation and properties of these micelles were investigated using 1 H NMR spectroscopy, fluorescence probe techniques and DLS. The reactive polymeric micelles were crosslinked with a di‐functional reagent. The crosslinked micelles showed improved stability and thiol reactivity. Cell viability tests indicated that the bioinspired phosphorylcholine‐based micelles showed excellent biocompatibility, thus promising great potential for applications in the field of nanocarrier systems. magnified image
Type of Medium:
Online Resource
ISSN:
1022-1352
,
1521-3935
DOI:
10.1002/macp.v211:21
DOI:
10.1002/macp.201000458
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
1475026-0
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