In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 72, No. 8_Supplement ( 2012-04-15), p. 2644-2644
Abstract:
Familial aggregation of testicular germ cell tumors (TGCT) has been reported, but it is unclear whether other cancers co-aggregate in multiple-case TGCT families. METHODS: We performed an observed-to-expected (O/E) analysis in a cohort of TGCT families with documented family cancer history assembled in Norway and the U.S. All bloodline first-degree relatives of TGCT cases were eligible. Relatives with missing vital status, gender, or dates of birth and/or death were excluded. We used population-based, age-adjusted cancer incidence rates from Norway and the Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute, respectively, to calculate expected numbers of cancer cases. Only non-TGCT cancers were analyzed. RESULTS: A total of 130 TGCT families with 84 reported cancers and 31,556 person-years at risk were included in the analysis. Overall, there was no excess cancer risk, all non-TGCT sites combined, observed among first-degree relatives of TGCT cases (O/E = 0.89; 95%CI 0.71 - 1.10), either collectively or stratified by center. Although numbers were small, site-specific increased risks were observed for soft tissue cancers (n=4; O/E=7.14; 95%CI 1.95 - 18.29) and leukemia (n=9; O/E=6.48; 95%CI 2.96 - 12.29), and site-specific decreased risk was observed for breast cancer (n=6; O/E=0.44; 95%CI 0.16 - 0.95). These risks were statistically significant overall and in Norway, but not in the U.S. CONCLUSION: In this, the largest study of site-specific cancer risk within multiple-case TGCT families yet performed, we found no excess risk of non-TGCT cancers overall among first-degree relatives of TGCT cases. There was limited evidence supporting altered site-specific risks for soft tissue cancer, leukemia and breast cancer; however, cancer numbers were small, and the results were not consistent between centers, suggesting that differences in cancer reporting among families, case validation methods, or other factors, rather than an etiologic association, explain these findings. Familial testicular cancer appears to be a site-specific syndrome. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2644. doi:1538-7445.AM2012-2644
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM2012-2644
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2012
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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