In:
Chemistry Central Journal, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2013-12)
Abstract:
Nanoparticles are potentially used for early cancer detection, accurate diagnosis, and cancer treatment. Results In this paper, the breast cancer cells treated with gold colloidal suspension were carefully studied by surface-enhanced Raman scattering (SERS) spectra. Raman spectroscopy combining with high-resolution electron microscope is employed to investigate the interaction of gold nanoparticles (GNPs) with the intracellular components. The TEM images show that the GNPs are taken into the living cells and enveloped into some vesicles named ‘lick up vesicles’ in the cytosol. Conclusions The SERS spectra and SERS mapping of cells indicate that the major Raman bands are mostly assigned to the vibration characteristics of proteins, and the C-H in-plane bending mode of the substituted benzene in Phenylalanine is remarkably enhanced. Finally, the interaction mechanisms of the GNPs with the intracellular components are further discussed in detail.
Type of Medium:
Online Resource
ISSN:
1752-153X
DOI:
10.1186/1752-153X-7-37
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2013
detail.hit.zdb_id:
2965009-4
detail.hit.zdb_id:
2272440-0
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