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  • 1
    Online Resource
    Online Resource
    EGFR mutations are associated with favorable intracranial response and progression-free survival following brain irradiation in non-small cell lung cancer patients with brain metastases
    Springer Science and Business Media LLC ; 2012
    In:  Radiation Oncology Vol. 7, No. 1 ( 2012-12)
    Details
    In: Radiation Oncology, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2012-12)
    Abstract: The presence of epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) is associated with increased radiosensitivity in vitro . However, the results from clinical studies regarding the radiosensitivity in NSCLC with mutant EGFR are inconclusive. We retrospectively analyzed our NSCLC patients who had been regularly followed up by imaging studies after irradiation for brain metastases, and investigated the impact of EGFR mutations on radiotherapy (RT). Methods Forty-three patients with brain metastases treated with RT, together with EGFR mutation status, demographics, smoking history, performance status, recursive partitioning analysis (RPA) class, tumor characteristics, and treatment modalities, were included. Radiological images were taken at 1 to 3 months after RT, and 3 to 6 months thereafter. Radiographic response was evaluated by RECIST criteria version 1.1 according to the intracranial images before and after RT. Log-rank test and Cox regression model were used to correlate EGFR mutation status and other clinical features with intracranial radiological progression-free survival (RPFS) and overall survival (OS). Results The median follow-up duration was 15 months. Patients with mutant EGFR had higher response rates to brain RT than those with wild-type EGFR (80% vs. 46%; p = 0.037). Logistic regression analysis showed that EGFR mutation status is the only predictor for treatment response ( p = 0.032). The median intracranial RPFS was 18 months (95% CI = 8.33-27.68 months). In Cox regression analysis, mutant EGFR ( p = 0.025) and lower RPA class ( p = 0.026) were associated with longer intracranial RPFS. EGFR mutation status ( p = 0.061) and performance status ( p = 0.076) had a trend to predict OS. Conclusions Mutant EGFR in NSCLC patients is an independent prognostic factor for better treatment response and longer intracranial RPFS following RT for brain metastases.
    Type of Medium: Online Resource
    ISSN: 1748-717X
    URL: Article
    DOI: 10.1186/1748-717X-7-181
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2012
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  • 2
    Online Resource
    Online Resource
    Epidermal Electronics
    American Association for the Advancement of Science (AAAS) ; 2011
    In:  Science Vol. 333, No. 6044 ( 2011-08-12), p. 838-843
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 333, No. 6044 ( 2011-08-12), p. 838-843
    Abstract: We report classes of electronic systems that achieve thicknesses, effective elastic moduli, bending stiffnesses, and areal mass densities matched to the epidermis. Unlike traditional wafer-based technologies, laminating such devices onto the skin leads to conformal contact and adequate adhesion based on van der Waals interactions alone, in a manner that is mechanically invisible to the user. We describe systems incorporating electrophysiological, temperature, and strain sensors, as well as transistors, light-emitting diodes, photodetectors, radio frequency inductors, capacitors, oscillators, and rectifying diodes. Solar cells and wireless coils provide options for power supply. We used this type of technology to measure electrical activity produced by the heart, brain, and skeletal muscles and show that the resulting data contain sufficient information for an unusual type of computer game controller.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.1206157
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2011
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
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  • 3
    Online Resource
    Online Resource
    A comparative study of cotton knitted fabrics and garments produced by the modified low twist and conventional ring yarns
    Springer Science and Business Media LLC ; 2010
    In:  Fibers and Polymers Vol. 11, No. 6 ( 2010-9), p. 899-904
    Details
    In: Fibers and Polymers, Springer Science and Business Media LLC, Vol. 11, No. 6 ( 2010-9), p. 899-904
    Type of Medium: Online Resource
    ISSN: 1229-9197 , 1875-0052
    URL: Article
    DOI: 10.1007/s12221-010-0899-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2010
    detail.hit.zdb_id: 2424081-3
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