In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 170, No. 1 ( 2014-01), p. 63-67
Abstract:
Although autoimmune thyroid disease is less common in males, it is unclear whether estrogen contributes to the difference in susceptibility among males. Objective To examine whether circulating estradiol (E 2 ) is related to thyroid autoimmunity in males. Patients and methods One-thousand two-hundred and sixty-three males aged 15–94 years were studied. Serum levels of E 2 , TSH receptor antibody (TRAb), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), free thyroxine (FT 4 ), and TSH were measured by ELISA. Results Circulating E 2 varied widely in males, ranging 18.4–403.7 pmol/l with a mean value of 136.2±51.7 pmol/l. E 2 increased with age ( r =0.18, P 〈 0.001). No relationship between E 2 and BMI was found. When comparing the difference in E 2 according to the test results of TRAb, TPOAb, and TgAb, it was found that E 2 was significantly higher in subjects with positive TRAb (TRAb positive, E 2 =170.3±59.8 pmol/l; TRAb negative, E 2 =134.0±50.6 pmol/l; P 〈 0.001). No difference in E 2 was demonstrated according to the results of TPOAb or TgAb. Logistic regression analysis showed that E 2 was a determinant of positive TRAb, independent of age and BMI. There was no relationship between serum E 2 and TSH or FT 4 . However, E 2 was negatively related to TSH ( r =−0.45, P 〈 0.01) in subjects whose TSH levels fell below the reference range (0.3–4.2 mIU/l). Conclusion Higher circulating E 2 is related to thyroid autoimmunity in males as reflected by positive TRAb.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2014
detail.hit.zdb_id:
1485160-X
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