In:
The Scientific World Journal, Hindawi Limited, Vol. 2013 ( 2013), p. 1-8
Abstract:
Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE) features. In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients. Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 ( P = 0.024 and P = 0.019 , resp.) and anti-Ro52/TRIM21 ( P = 0.026 and P = 0.022 , resp.). In contrast, a negative association was detected regarding anti-phospholipid antibodies, anti-SSA/Ro60 having a stronger effect ( P = 0.014 ) than anti-Ro52/TRIM21. Anti-SSA/Ro60 showed a specific positive association with hypocomplementemia ( P = 0.041 ), mainly with low C4 levels ( P = 0.008 ), whereas anti-Ro52/TRIM21 was found to be positively associated with Raynaud’s phenomenon ( P = 0.026 ) and cytopenia ( P = 0.048 ) and negatively associated with anti-dsDNA ( P = 0.013 ). Lymphocytes are involved in the relationship between anti-Ro52/TRIM21 and cytopenia since positive patients showed lower cell levels than negative patients ( P = 0.036 ). In conclusion, anti-SSA/Ro60 and anti-Ro52/TRIM21 showed both common and specific associations in SLE. These data thus increase evidence of the different associations of the two anti-Ro specificities even in a particular disease.
Type of Medium:
Online Resource
ISSN:
1537-744X
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2013
detail.hit.zdb_id:
2075968-X
Permalink