GLORIA

GEOMAR Library Ocean Research Information Access

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    In: Otolaryngology–Head and Neck Surgery, Wiley, Vol. 151, No. S1 ( 2014-09)
    Abstract: Determine the safety and efficacy of SPI‐1005, a novel oral glutathione peroxidase (GPx) mimic and inducer, in preventing and treating noise‐induced hearing loss (NIHL) in adults ranging from slight hearing loss (≤25 dBHL) to normal hearing. Methods: Randomized double blind placebo controlled Phase 2 clinical trial conducted December 2012 through November 2013. A total of 83 subjects at the University of Florida were enrolled and treated with either placebo or SPI‐1005 prior to a single iPod sound exposure lasting 4 hours that induced a slight temporary threshold shift (TTS). The incidence (≥10 dBHL), severity (dBHL), and duration (up to 1 week post sound) of the TTS were determined by serial pure tone audiometry. The intervention (200, 400, or 600 mg SPI‐1005 twice daily × 4 days) was compared with matching placebo in reducing the TTS. Significance was determined by 2‐tailed t tests comparing a specific SPI‐1005 treatment group versus placebo. Results: Oral SPI‐1005 treatment showed a significant reduction in TTS incidence (60% vs 20%, P 〈 . 01), severity (4.2 vs 1.1 dBHL at 4 kHz, P 〈 . 01), and duration (24 vs 1.3 hours, P 〈 . 01). SPI‐1005 treatment was well tolerated with no drug‐related adverse events (CBC, Chem20, chest x‐ray). Conclusions: SPI‐1005 treatment demonstrated clinically relevant reductions in TTS induced by loud sound exposure. Multiday treatment with all SPI‐1005 dosages was well tolerated. These data support the continued development of SPI‐1005 in noise exposed populations and the GPx mechanism of action in preventing and treating NIHL.
    Type of Medium: Online Resource
    ISSN: 0194-5998 , 1097-6817
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2008453-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Online Resource
    Online Resource
    Wiley ; 2010
    In:  The Laryngoscope Vol. 120, No. 6 ( 2010-06), p. 1214-1219
    In: The Laryngoscope, Wiley, Vol. 120, No. 6 ( 2010-06), p. 1214-1219
    Abstract: Medication errors are a common cause of poor clinical outcomes. Information on perioperative medication errors is scarce. This study was aimed at identifying the nature, cause, and potential remedies for medication errors in otolaryngologic surgery. Study Design: Prospective and descriptive. Methods: Clinicians were incentivized for reporting possible medication errors that occurred from the preoperative through the first postoperative clinic visit over a 2‐month period. Each report was investigated by an expert panel to determine validity, preventability, contributing factors, and potential preventative measures. A random sample of procedures and clinic visits were monitored for compliance with safe medication practices and information flow. Results: From 589 surgeries, 20 medication errors were reported (two preoperative, four operative, five during hospital admission, two in transition between services, four during discharge, and three postoperative). Errors included wrong dose (seven), omitted dose (six), wrong drug (five), wrong site (two), and unnecessary drug (one). Causes included failure to consider weight‐based dosing, use accurate drug references, calculate the total medication supply needed, verify the administration site, consider pertinent patient information (e.g., allergies), reconcile medications upon transfers, and document medication histories. Use of preprinted order forms was flawed, and discharge instructions were insufficient to guide patients postoperatively. Conclusions: Failure to adhere to safe medication‐use practices occurred throughout perioperative care. Improvement in medication documentation, following established safe practices, integration of patient information in prescribing decisions, and use of clinical decision support systems appear necessary to prevent perioperative medication errors in otolaryngology.
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2026089-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2013
    In:  International Journal for Quality in Health Care Vol. 25, No. 5 ( 2013-10), p. 573-581
    In: International Journal for Quality in Health Care, Oxford University Press (OUP), Vol. 25, No. 5 ( 2013-10), p. 573-581
    Type of Medium: Online Resource
    ISSN: 1464-3677 , 1353-4505
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2013
    detail.hit.zdb_id: 2002180-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...