In:
The FASEB Journal, Wiley, Vol. 27, No. S1 ( 2013-04)
Abstract:
The Dietary Guidelines for Americans (DGA) aim to reduce chronic diseases. Inflammation is an established risk factor for Type 2 diabetes, hypertension, and CVD. We examined cross‐sectional associations between adherence to the 2010 DGA and inflammation among 2,200 Framingham Offspring study participants (mean age 61.3 years, 46% male). Adherence to the 2010 DGA was assessed by the 2010 Dietary Guidelines for Americans Index (DGAI_2010), possible range 0 worst to 100 maximum adherence (mean 59.1, range 24.3–86.3). Eleven inflammatory biomarkers were ranked and compiled into an inflammation score (IS): CRP, ICAM, CD40P, IL‐6, MCP1, MPO, P‐Selectin, TNFR2, OPG, and LPL‐A2 mass and activity, possible range 0 lowest to 11 highest level of inflammation (mean 4.9, range 1.4–8.9). Using multivariable linear regression, we observed an inverse association between continuous DGAI_2010 and IS adjusted for age, sex, BMI, smoking and NSAIDS use (p 〈 0.001). Analysis of adjusted means IS by quintiles of the DGAI_2010 (quintile means 43.2, 53.5, 59.7, 65.6 and 73.3) showed lower IS in the highest two DGAI_2010 categories (IS means 4.7 and 4.8) vs lowest (IS mean 5.1) with Tukey adjustment (p 〈 0.001). Greater adherence to the 2010 DGA may decrease chronic disease prevalence due to reduced risk of inflammation. Supported by grants from NIH (N01‐HC 25195, RO1 HL64753; R01 HL076784; R01 AG028321) and USDA (agreement 58–1950‐0–014).
Type of Medium:
Online Resource
ISSN:
0892-6638
,
1530-6860
DOI:
10.1096/fasebj.27.1_supplement.lb397
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
1468876-1
detail.hit.zdb_id:
639186-2
SSG:
12
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