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  • 1
    Online-Ressource
    Online-Ressource
    Feasibility of Delivering Mesenchymal Stem Cells via Catheter to the Proximal End of the Lesion Artery in Patients with Stroke in the Territory of the Middle Cerebral Artery
    SAGE Publications ; 2013
    In:  Cell Transplantation Vol. 22, No. 12 ( 2013-12), p. 2291-2298
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 22, No. 12 ( 2013-12), p. 2291-2298
    Kurzfassung: Stem cell-based therapy shows great potential in stroke patients. Intra-artery infusion exhibits greater biological distribution compared to intravenous delivery. In addition, umbilical cord mesenchymal stem cells (UCMSCs) have several advantages compared with other types of stem cells. The aim of this study was to evaluate the safety and efficacy of UCMSCs delivered by a catheter to a near lesion site for treatment of an infarction in the middle cerebral artery territory. Four patients with stroke (three with ischemic and one with hemorrhagic stroke) in the middle cerebral artery territory were recruited in this study. One single dose of 2 × 10 7 UCMSCs was infused within 20 min via catheterization in the M1 segment of the middle cerebral artery. The safety and efficacy of this approach were assessed during the in-hospital and 6-month follow-up evaluation. The cell delivery was successfully performed in all of the patients, and no major accidents (stroke or death) were observed. Moreover, no fever or rash was reported. After cellular therapy, two of the three ischemic stroke patients demonstrated improved muscle strength. The improvement of the modified Rankin scale was observed in two patients, both of whom suffered from ischemic stroke at 90 and 180 days after the stem cell therapy. The hemorrhagic stroke patient failed to demonstrate improved muscle strength and did not amend his daily activities. Intra-artery delivery of UCMSCs via catheterization was a feasible and safe approach and may improve the neurological function of ischemic stroke patients with the middle cerebral artery territory infarcts.
    Materialart: Online-Ressource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/096368912X658818
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2013
    ZDB Id: 1135816-6
    ZDB Id: 2020466-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism
    Walter de Gruyter GmbH ; 2011
    In:  cclm Vol. 49, No. 2 ( 2011-02-01), p. 185-189
    Details
    In: cclm, Walter de Gruyter GmbH, Vol. 49, No. 2 ( 2011-02-01), p. 185-189
    Kurzfassung: Background: Decreased brain-derived neurotrophic factor (BDNF) has been demonstrated in animal models and patients with depression. However, little is known about changes in BDNF in post-stroke depression (PSD). This study investigated the changes in serum BDNF in patients with PSD, and evaluated whether serum concentrations of BDNF were associated with BDNF gene Val66Met polymorphism. Methods: PSD patients were diagnosed in accordance with DSM-IV criteria, and the severity of depression was evaluated with the Hamilton Rating Scale for depression. Serum BDNF was measured twice, first at 7 days after the onset of stroke and then at 3–6 months after stroke. Val66Met polymorphisms of the BDNF gene were determined using the polymerase chain reaction-restriction fragment length polymorphism method. BDNF concentrations and Val66Met polymorphisms were also measured in 30 healthly controls. Results: A total of 93 patients admitted as a result of first time acute ischemic stroke were included. During the 6-month follow-up, 35 patients (37.6%) were diagnosed with PSD. Serum BDNF concentrations were decreased in PSD patients at 3–6 months after stroke (p 〈 0.05). The serum BDNF concentrations were not associated with BDNF gene Val66Met polymorphisms in either patients or healthy controls. Conclusions: Serum concentrations of BDNF decrease in PSD patients and BDNF may play an important role in the pathogenesis of PSD. However, Val66Met polymorphisms are not associated with serum concentrations of BDNF. The mechanism of decreased serum BDNF requires further study.
    Materialart: Online-Ressource
    ISSN: 1437-4331 , 1434-6621
    URL: Article
    DOI: 10.1515/CCLM.2011.039
    Sprache: Englisch
    Verlag: Walter de Gruyter GmbH
    Publikationsdatum: 2011
    ZDB Id: 1418007-8
    ZDB Id: 1492732-9
    SSG: 15,3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Atomistic simulation study of surfactant and polymer interactions on the surface of a fenofibrate crystal
    Elsevier BV ; 2011
    In:  European Journal of Pharmaceutical Sciences Vol. 42, No. 5 ( 2011-4), p. 452-461
    Details
    In: European Journal of Pharmaceutical Sciences, Elsevier BV, Vol. 42, No. 5 ( 2011-4), p. 452-461
    Materialart: Online-Ressource
    ISSN: 0928-0987
    URL: Article
    DOI: 10.1016/j.ejps.2011.01.009
    Sprache: Englisch
    Verlag: Elsevier BV
    Publikationsdatum: 2011
    ZDB Id: 1154366-8
    SSG: 15,3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
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    Bistable memory devices with lower threshold voltage by extending the molecular alkyl-chain length
    Royal Society of Chemistry (RSC) ; 2013
    In:  Physical Chemistry Chemical Physics Vol. 15, No. 23 ( 2013), p. 9212-
    Details
    In: Physical Chemistry Chemical Physics, Royal Society of Chemistry (RSC), Vol. 15, No. 23 ( 2013), p. 9212-
    Materialart: Online-Ressource
    ISSN: 1463-9076 , 1463-9084
    URL: Article
    DOI: 10.1039/c3cp51290h
    Sprache: Englisch
    Verlag: Royal Society of Chemistry (RSC)
    Publikationsdatum: 2013
    ZDB Id: 1476244-4
    ZDB Id: 1460656-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
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    Distal Hyperintense Vessels on Flair: A Prognostic Indicator of Acute Ischemic Stroke
    S. Karger AG ; 2012
    In:  European Neurology Vol. 68, No. 4 ( 2012), p. 214-220
    Details
    In: European Neurology, S. Karger AG, Vol. 68, No. 4 ( 2012), p. 214-220
    Kurzfassung: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Hyperintense vessels (HVs) on fluid-attenuated inversion recovery (FLAIR) are frequently observed in acute ischemic stroke (AIS). The presence of HVs represents altered blood flow from collaterals distal to arterial occlusion or stenosis. This study aimed to evaluate the prognostic value of HVs in AIS. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Fifty-four consecutive patients with acute middle cerebral artery occlusion were enrolled in the study. The location and extent of the HVs was determined by FLAIR. Clinical data were obtained and compared between patients with different grades of HVs. Additionally, the relationship between distal HVs and leptomeningeal collaterals (LMCs) was assessed using angiography. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 HVs were observed in 41 (75.9%) of the 54 patients enrolled. The initial NIHSS score was lower (p 〈 0.001) and the infarction volume was smaller (p 〈 0.001) in patients with distal HVs. Adjusting of other factors, regression analysis revealed that distal HVs are an independent predictor of a favorable outcome at 90 days (p = 0.006; OR 0.049; 95% CI 0.006–0.420). Furthermore, the presence of distal HVs was correlated with the presence of LMCs. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Distal HVs may be a marker for LMCs and act as a predictor of a favorable clinical outcome for patients with AIS.
    Materialart: Online-Ressource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000340021
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2012
    ZDB Id: 209426-5
    ZDB Id: 1482237-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
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    Correlation between ABCD, ABCD2 Scores and Craniocervical Artery Stenosis in Patients with Transient Ischemic Attack
    S. Karger AG ; 2013
    In:  European Neurology Vol. 70, No. 5-6 ( 2013), p. 333-339
    Details
    In: European Neurology, S. Karger AG, Vol. 70, No. 5-6 ( 2013), p. 333-339
    Kurzfassung: 〈 b 〉 〈 i 〉 Background and Purpose: 〈 /i 〉 〈 /b 〉 Craniocervical artery stenosis is an important etiology for transient ischemic attack (TIA). We hypothesized ABCD and ABCD2 scores can predict craniocervical artery stenosis in patients with TIA. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 ABCD and ABCD2 scores were calculated in a total of 479 consecutive first-ever TIA patients in Nanjing Stroke Registry Program and compared with angiographic imaging derived from MRI or invasive catheter-based angiography. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Overall craniocervical artery (O-CA) stenosis was found in 197 (41.1%) patients. Extracranial craniocervical artery (E-CA) and intracranial craniocervical artery (I-CA) stenosis was found in 101 (21.1%) and 110 (23%) cases, respectively. ABCD and ABCD2 scores with similar accuracy for O-CA (AUC 〈 sub 〉 ABCD 〈 /sub 〉 0.71, AUC 〈 sub 〉 ABCD2 〈 /sub 〉 0.70), E-CA (AUC 〈 sub 〉 ABCD 〈 /sub 〉 0.72, AUC 〈 sub 〉 ABCD2 〈 /sub 〉 0.72) and I-CA stenosis (AUC 〈 sub 〉 ABCD 〈 /sub 〉 0.62, AUC 〈 sub 〉 ABCD2 〈 /sub 〉 0.62) were both independent predictors for various categories of artery stenosis after being adjusted for non-ABCD2 parameters. The cut-off points were equally 4 in both predicting rules. For ABCD, sensitivity was 57.4, 65.3 and 52.7% and specificity 77.0, 70.4 and 67.5% for O-CA/E-CA/I-CA, respectively. For ABCD2, sensitivity was 61.9, 69.3 and 58.2% and specificity 72.3, 65.6 and 63.1%. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 In patients with TIA, despite an association between ABCD and ABCD2 scores and underlying craniocervical artery stenosis, the clinical utility was limited by unsatisfactory sensitivity and specificity.
    Materialart: Online-Ressource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000353299
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2013
    ZDB Id: 209426-5
    ZDB Id: 1482237-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    China Interventional Stroke Registry: Rationale and Study Design
    S. Karger AG ; 2013
    In:  Cerebrovascular Diseases Vol. 35, No. 4 ( 2013), p. 349-354
    Details
    In: Cerebrovascular Diseases, S. Karger AG, Vol. 35, No. 4 ( 2013), p. 349-354
    Kurzfassung: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Angioplasty and stenting have recently become attractive options for cerebral large artery stenosis in China. However, there are limited data on safety and long-term outcomes in Chinese patients having undergone cerebral interventional procedures. To address this need, we set up a common database - the China Interventional Stroke Registry (CISR) - to describe patient characteristics, interventional images, periprocedural complications and long-term clinical outcomes and to determine how adherence to guideline-based treatments in the ‘real world' works in China. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Six medical centers have participated since 2004. They entered into an Internet-based database data on demographics, clinical history and angiography of patients undergoing angioplasty with/without stenting in extracranial arteries (carotid, vertebral and subclavian arteries) and/or intracranial arteries (middle cerebral artery, vertebral artery and basilar artery) in China. CISR is a research-funded project. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 As of October 2012, we have already collected detailed clinical information on 1,356 patients (age: 63.6 ± 10.2 years, male: 1,084, 79.9%). The overall data quality is good. Site data quality control is supported via detailed monthly feedback reports and quarterly data monitoring meetings. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The CISR is the first and the largest registry for angioplasty with/without stents in China. The database will provide the characteristics and outcomes of patients and the situation of adherence to guideline-based treatments under ‘real-world' conditions in China.
    Materialart: Online-Ressource
    ISSN: 1015-9770 , 1421-9786
    URL: Article
    DOI: 10.1159/000350210
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2013
    ZDB Id: 1482069-9
    ZDB Id: 1069462-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Argatroban for Preventing Occlusion and Restenosis after Extracranial Artery Stenting
    S. Karger AG ; 2014
    In:  European Neurology Vol. 71, No. 5-6 ( 2014), p. 319-325
    Details
    In: European Neurology, S. Karger AG, Vol. 71, No. 5-6 ( 2014), p. 319-325
    Kurzfassung: 〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 Restenosis following extracranial artery stenting is a limitation that affects long-term outcomes. Effective and satisfying pharmacological strategies in preventing restenosis have not been established. This study aimed to evaluate whether argatroban, a direct thrombin inhibitor, could reduce the risk of in-stent restenosis after extracranial artery stenting. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 One hundred and fourteen patients hospitalized between August 2010 and August 2011 were enrolled. Patients were randomly assigned to argatroban (n = 58) and blank control groups (n = 56). The patients in the argatroban arm were treated with 10 mg of intravenous argatroban twice daily 2 days before and 3 days after the stenting procedures. Patients were followed for 12 months after the procedure. During follow-up, restenosis and target revascularization were analyzed. Recurrent cerebrovascular and cardiovascular events and deaths were also compared between the groups. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 One patient in the stenting group withdrew immediately after the procedure due to unsuccessful stenting. Restenosis occurred in 4 patients (7.4%) in the argatroban group and in 11 patients (21.6%) in the control group during the 6- to 9-month angiographic follow-up period (p = 0.032). Nine months after the procedures, argatroban-treated patients had a trend towards a lower incidence of target revascularization compared with the controls (5.4 vs. 13.7%, p = 0.188). No major bleeding events or other adverse events occurred in the argatroban group. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 This pilot clinical trial is the first that uses argatroban to prevent restenosis in ischemic cerebrovascular disease, and suggests that intravenous administration of argatroban is effective and safe in preventing restenosis after extracranial artery stenting. Larger randomized controlled clinical trials are warranted.
    Materialart: Online-Ressource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000357866
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2014
    ZDB Id: 209426-5
    ZDB Id: 1482237-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    Relationship between Cerebral Atherosclerosis and Leukoaraiosis in Aged Patients: Results from DSA
    Wiley ; 2014
    In:  Journal of Neuroimaging Vol. 24, No. 4 ( 2014-07), p. 338-342
    Details
    In: Journal of Neuroimaging, Wiley, Vol. 24, No. 4 ( 2014-07), p. 338-342
    Kurzfassung: There are some controversial results on the relationship between cerebral atherosclerosis and leukoaraiosis in the published papers, where cerebral atherosclerosis was often evaluated by ultrasonography, CTA or MRA. We analyzed data in which patients underwent both MRI and DSA to explore the above relationship in the aged people. METHODS Three hundred and thirty‐three patients were enrolled in the study from the Nanjing Stroke Registry. They underwent both cerebral DSA and MRI. Age, sex, and vascular risk factors were collected. Atherosclerosis was scored from grade 0 to 4. Leukoaraiosis was scored from grade 0 to 3. RESULTS Cerebral artery stenosis was not correlated with the presence of leukoaraiosis. There were no correlations between the number of cerebral moderately or more severely stenotic arteries and the severity of leukoaraiosis in periventricular, deep, or whole white matter ( P = .747, .268, and .608, respectively). Old age (odds ratio = 1.103, P = .027) and hypertension (odds ratio = 2.748, P = .003) were correlated with leukoaraiosis in the periventricular white matter. Old age (odds ratio = 1.073, P = .031) and prior stroke (odds ratio = 2.678, P = .002) were correlated with leukoaraiosis in the deep white matter. CONCLUSIONS No apparent correlation exists between cerebral artery stenosis and the presence and severity of leukoaraiosis.
    Materialart: Online-Ressource
    ISSN: 1051-2284 , 1552-6569
    URL: Issue
    URL: Article
    DOI: 10.1111/jon.2014.24.issue-4
    DOI: 10.1111/jon.12047
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2014
    ZDB Id: 1071724-9
    ZDB Id: 2035400-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism Contributes to Ischemic Stroke Risk: A Meta-Analysis of 50 Case-Control Studies
    Public Library of Science (PLoS) ; 2012
    In:  PLoS ONE Vol. 7, No. 10 ( 2012-10-1), p. e46495-
    Details
    In: PLoS ONE, Public Library of Science (PLoS), Vol. 7, No. 10 ( 2012-10-1), p. e46495-
    Materialart: Online-Ressource
    ISSN: 1932-6203
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1371/journal.pone.0046495
    DOI: 10.1371/journal.pone.0046495.g001
    DOI: 10.1371/journal.pone.0046495.g002
    DOI: 10.1371/journal.pone.0046495.g003
    DOI: 10.1371/journal.pone.0046495.g004
    DOI: 10.1371/journal.pone.0046495.t001
    DOI: 10.1371/journal.pone.0046495.t002
    Sprache: Englisch
    Verlag: Public Library of Science (PLoS)
    Publikationsdatum: 2012
    ZDB Id: 2267670-3
    Standort Signatur Einschränkungen Verfügbarkeit
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