In:
Macromolecular Chemistry and Physics, Wiley, Vol. 214, No. 24 ( 2013-12), p. 2875-2881
Abstract:
Linear amphiphilic triblock polymers containing a single diselenide (SeSe‐tri‐ABP) are synthesized by coupling reactions. They self‐assemble into spherical micelles 1 in aqueous solution. A remarkable morphology transformation of the micelles is confirmed through dynamic light scattering (DLS) and transmission electron microscopy (TEM). The release behavior of a model molecule, Rhodamine B (RB), is studied by UV–vis spectrophotometry. It is found that post‐assembly from micelles 1 to micelles 2 is induced by the oxidation‐responsive cleavage of the diselenide group in the oxidation solution. Interestingly, the RB release studies reveal that these micelles release RB in a diphasic pattern (slow after initial fast release) within 24 h under an oxidative environment. In contrast, minimal drug release ( 〈 20%) is observed within 24 h for SeSe‐tri‐ABP micelles under aqueous conditions. Meanwhile, this release behavior of the RB‐loaded micelles can be tuned by the post‐assembly of oxidation‐responsive SeSe‐tri‐ABP in different oxidation conditions, providing a promising platform for controlled delivery of nanocarriers. image
Type of Medium:
Online Resource
ISSN:
1022-1352
,
1521-3935
DOI:
10.1002/macp.v214.24
DOI:
10.1002/macp.201300579
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
1475026-0
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