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  • Free Research Articles, Myeloid Neoplasia, Brief Reports, Clinical Trials and Observations  (2)
  • Electronic data processing -- Distributed processing.  (1)
  • 2010-2014  (3)
  • 1
    Online Resource
    Online Resource
    New Paradigms in Internet Computing. (2012)
    Berlin, Heidelberg :Springer Berlin / Heidelberg,
    Details
    Keywords: Electronic data processing -- Distributed processing. ; Electronic books.
    Description / Table of Contents: This book examines leading research and developments in Internet technology, including contributions from academic researchers as well as industry experts discussing new paradigms in Software, Protocols, Supply Chain Management, Security and Cloud Computing.
    Type of Medium: Online Resource
    Pages: 1 online resource (83 pages)
    Edition: 1st ed.
    ISBN: 9783642354618
    Series Statement: Advances in Intelligent Systems and Computing Series ; v.203
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=1082899
    Language: English
    Note: Title Page -- Preface -- Contents -- Enhanced Mobile Ad hoc Routing Protocol Using Cross Layer Design in Wireless Sensor Networks -- Introduction -- Theory -- IEEE 802.15.4 Standard -- Ad hoc On-Demand Distance Vector (AODV) Protocol -- Cross Layer Design -- Propose Energy Weigh - AODV Protocol -- The Simulation -- Result and Performance Analysis -- Conclusion -- References -- Decision Support in Supply Chain Management for Disaster Relief in Somalia -- Introduction -- The Importance of Disaster Management -- Somalia as a Case Study -- Literature Review -- Problem Variants -- Existing Solutions -- Preemptive Multiobjective Programming -- Research Methodology -- Preemptive Optimization -- Data Gathering -- Results and Findings -- Conclusion and Future Work -- References -- Challenges in Cloud Environment -- System Quality Attributes -- Portability -- Recoverability -- Maintainability -- Transparency and Control -- Security -- OS Support -- RHEL Migration on AWS Cloud - An Experience -- Amazon as-is Architecture -- Migration from DevPay to Hourly on Demand -- Infrastructure as Code -- Recommendations -- Manageability -- Configurability -- Maintainability -- Portability -- Conclusion -- Challenges on Amazon Cloud in Load Balancing, Performance Testing and Upgrading -- Hosting a Web Application on Cloud -- Issues with Traditional Infrastructure -- Typical Web Application Topology -- Web Application on AWS -- Components Used -- Learning and Recommendations -- Load Balancers -- Auto Discovery of EC2 Nodes -- Performance Testing Environment -- Application Setup -- Load Generation Strategy -- Measurable Parameters -- Test Results -- Observations -- Recommendation -- Learning -- Conclusion -- A Rule-Based Approach for Effective Resource Provisioning in Hybrid Cloud Environment -- Introduction -- Objectives -- Resource Manager -- Related Work. , Rule Based Resource Manager -- Experimental Evaluation -- Conclusion -- References -- Browser Based IDE to Code in the Cloud -- Introduction -- Cloud Computing -- Integrated Development Environment -- Browser Based Integrated Development Environment -- Real Time Collaboration -- Forums -- Technical Blogs -- Existing Browser Based Coding Environment -- Cloud9 IDE -- CodeRun Studio [7] -- Eclipse Orion [8] -- Ideone -- eXo Cloud IDE -- Proposed System -- Design -- Real Time Collaboration -- Integrated Forum -- Technical Blogs -- Conclusion -- Zero Knowledge Password Authentication Protocol -- Introduction -- Motivation -- Contribution -- Organization of Paper -- Notations and Definitions -- Notations -- Definitions -- Relevance to Prior Work -- Cryptographic Primitives -- The Proposed Security Protocol : Zero Knowledge Password Authentication Protocol (ZK-PAP) -- ZK-PAP with PKE -- Conclusion -- References -- Author Index.
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  • 2
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    SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival (2012)
    American Society of Hematology (ASH)
    In: Blood
    Details
    Publication Date: 2012-11-16
    Description: Among spliceosome component mutations, those involving SF3B1 are most frequent in myelodysplastic syndromes with ring sideroblasts (MDS-RS; ~ 75% incidence) and SRSF2 in chronic myelomonocytic leukemia (~ 28% incidence). We recently reported on the lack of prognostic significance for SF3B1 mutations in both MDS-RS and primary myelofibrosis (PMF). In the current study, we examined the prevalence and prognostic relevance of SRSF2 mutations in PMF. Among 187 patients screened, 32 (17%) harbored SRSF2 monoallelic mutations affecting residue P95. Significant associations were demonstrated between SRSF2 mutations and advanced age ( P 〈 .01), IDH mutations ( P 〈 .01), and higher DIPSS-plus risk category ( P = .03). SRSF2 mutations were associated with shortened overall ( P 〈 .01) and leukemia-free ( P 〈 .01) survival; the adverse effect on survival was independent of DIPSS-plus ( P = .01; HR = 1.9; 95% CI, 1.1-3.0) and IDH mutations ( P 〈 .01; HR = 2.3; 95% CI, 1.4-3.8). In conclusion, SRSF2 mutations are relatively common in PMF, cluster with IDH mutations, and are independently predictive of poor outcome.
    Keywords: Free Research Articles, Myeloid Neoplasia, Brief Reports, Clinical Trials and Observations
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology (ASH)
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    PAPER CURRENT
  • 3
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    Prognostic irrelevance of ring sideroblast percentage in World Health Organization-defined myelodysplastic syndromes without excess blasts (2012)
    American Society of Hematology (ASH)
    In: Blood
    Details
    Publication Date: 2012-06-15
    Description: The presence of ≥ 15% bone marrow (BM) ring sideroblasts (RS) and 〈 5% blasts is required for a diagnosis of refractory anemia with ring sideroblasts. We examined the phenotypic and prognostic relevance of this "15%" RS threshold in 200 patients with myelodysplastic syndromes (MDS) without excess blasts and with ≥ 1% RS. The impact of RS% was assessed both as a continuous and categorical variable: 〈 5% (n = 56), 5%-14% (n = 32), 15%-50% (n = 79), and 〉 50% (n = 33). RS% correlated ( P 〈 .05) directly with age, platelet count, transfusion dependency, BM cellularity, and mutant SF3B1 and inversely with hemoglobin level, multilineage dysplasia, and high-risk karyotype; but did not correlate with IDH mutations. At a median follow-up of 33 months, 156 (73%) deaths and 24 (12%) leukemic transformations were documented. Neither univariate nor multivariable analysis showed significant effect for RS% on overall or leukemia-free survival, suggesting the limited prognostic value of quantifying BM RS in MDS.
    Keywords: Free Research Articles, Myeloid Neoplasia, Brief Reports, Clinical Trials and Observations
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology (ASH)
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    PAPER CURRENT
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