GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    New Paradigms in Internet Computing. (2012)
    Berlin, Heidelberg :Springer Berlin / Heidelberg,
    Details
    Keywords: Electronic data processing -- Distributed processing. ; Electronic books.
    Description / Table of Contents: This book examines leading research and developments in Internet technology, including contributions from academic researchers as well as industry experts discussing new paradigms in Software, Protocols, Supply Chain Management, Security and Cloud Computing.
    Type of Medium: Online Resource
    Pages: 1 online resource (83 pages)
    Edition: 1st ed.
    ISBN: 9783642354618
    Series Statement: Advances in Intelligent Systems and Computing Series ; v.203
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=1082899
    Language: English
    Note: Title Page -- Preface -- Contents -- Enhanced Mobile Ad hoc Routing Protocol Using Cross Layer Design in Wireless Sensor Networks -- Introduction -- Theory -- IEEE 802.15.4 Standard -- Ad hoc On-Demand Distance Vector (AODV) Protocol -- Cross Layer Design -- Propose Energy Weigh - AODV Protocol -- The Simulation -- Result and Performance Analysis -- Conclusion -- References -- Decision Support in Supply Chain Management for Disaster Relief in Somalia -- Introduction -- The Importance of Disaster Management -- Somalia as a Case Study -- Literature Review -- Problem Variants -- Existing Solutions -- Preemptive Multiobjective Programming -- Research Methodology -- Preemptive Optimization -- Data Gathering -- Results and Findings -- Conclusion and Future Work -- References -- Challenges in Cloud Environment -- System Quality Attributes -- Portability -- Recoverability -- Maintainability -- Transparency and Control -- Security -- OS Support -- RHEL Migration on AWS Cloud - An Experience -- Amazon as-is Architecture -- Migration from DevPay to Hourly on Demand -- Infrastructure as Code -- Recommendations -- Manageability -- Configurability -- Maintainability -- Portability -- Conclusion -- Challenges on Amazon Cloud in Load Balancing, Performance Testing and Upgrading -- Hosting a Web Application on Cloud -- Issues with Traditional Infrastructure -- Typical Web Application Topology -- Web Application on AWS -- Components Used -- Learning and Recommendations -- Load Balancers -- Auto Discovery of EC2 Nodes -- Performance Testing Environment -- Application Setup -- Load Generation Strategy -- Measurable Parameters -- Test Results -- Observations -- Recommendation -- Learning -- Conclusion -- A Rule-Based Approach for Effective Resource Provisioning in Hybrid Cloud Environment -- Introduction -- Objectives -- Resource Manager -- Related Work. , Rule Based Resource Manager -- Experimental Evaluation -- Conclusion -- References -- Browser Based IDE to Code in the Cloud -- Introduction -- Cloud Computing -- Integrated Development Environment -- Browser Based Integrated Development Environment -- Real Time Collaboration -- Forums -- Technical Blogs -- Existing Browser Based Coding Environment -- Cloud9 IDE -- CodeRun Studio [7] -- Eclipse Orion [8] -- Ideone -- eXo Cloud IDE -- Proposed System -- Design -- Real Time Collaboration -- Integrated Forum -- Technical Blogs -- Conclusion -- Zero Knowledge Password Authentication Protocol -- Introduction -- Motivation -- Contribution -- Organization of Paper -- Notations and Definitions -- Notations -- Definitions -- Relevance to Prior Work -- Cryptographic Primitives -- The Proposed Security Protocol : Zero Knowledge Password Authentication Protocol (ZK-PAP) -- ZK-PAP with PKE -- Conclusion -- References -- Author Index.
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    GEOMAR EBL
  • 2
    facet.materialart.
    Unknown
    Noncanonical TGFbeta signaling contributes to aortic aneurysm progression in Marfan syndrome mice (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-16
    Description: Transforming growth factor-beta (TGFbeta) signaling drives aneurysm progression in multiple disorders, including Marfan syndrome (MFS), and therapies that inhibit this signaling cascade are in clinical trials. TGFbeta can stimulate multiple intracellular signaling pathways, but it is unclear which of these pathways drives aortic disease and, when inhibited, which result in disease amelioration. Here we show that extracellular signal-regulated kinase (ERK) 1 and 2 and Smad2 are activated in a mouse model of MFS, and both are inhibited by therapies directed against TGFbeta. Whereas selective inhibition of ERK1/2 activation ameliorated aortic growth, Smad4 deficiency exacerbated aortic disease and caused premature death in MFS mice. Smad4-deficient MFS mice uniquely showed activation of Jun N-terminal kinase-1 (JNK1), and a JNK antagonist ameliorated aortic growth in MFS mice that lacked or retained full Smad4 expression. Thus, noncanonical (Smad-independent) TGFbeta signaling is a prominent driver of aortic disease in MFS mice, and inhibition of the ERK1/2 or JNK1 pathways is a potential therapeutic strategy for the disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111087/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111087/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holm, Tammy M -- Habashi, Jennifer P -- Doyle, Jefferson J -- Bedja, Djahida -- Chen, YiChun -- van Erp, Christel -- Lindsay, Mark E -- Kim, David -- Schoenhoff, Florian -- Cohn, Ronald D -- Loeys, Bart L -- Thomas, Craig J -- Patnaik, Samarjit -- Marugan, Juan J -- Judge, Daniel P -- Dietz, Harry C -- P01 AR049698/AR/NIAMS NIH HHS/ -- P01 AR049698-07/AR/NIAMS NIH HHS/ -- R01 AR041135/AR/NIAMS NIH HHS/ -- R01 AR041135-12/AR/NIAMS NIH HHS/ -- R01 AR041135-17/AR/NIAMS NIH HHS/ -- Howard Hughes Medical Institute/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2011 Apr 15;332(6027):358-61. doi: 10.1126/science.1192149.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21493862" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthracenes/pharmacology/therapeutic use ; Aorta/pathology ; Aortic Aneurysm/*metabolism/pathology/physiopathology/prevention & control ; Diphenylamine/analogs & derivatives/pharmacology/therapeutic use ; Disease Models, Animal ; Disease Progression ; Enzyme Activation ; Losartan/pharmacology/therapeutic use ; *MAP Kinase Signaling System ; Marfan Syndrome/drug therapy/*metabolism/pathology ; Mice ; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors/*metabolism ; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors/*metabolism ; Mitogen-Activated Protein Kinase 8/antagonists & inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology/therapeutic use ; Smad2 Protein/metabolism ; Smad4 Protein/deficiency/genetics ; Sulfonamides/pharmacology/therapeutic use ; Transforming Growth Factor beta/antagonists & inhibitors/immunology/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...